A study of neuroendocrinological mechanisms underlying a women's vulnerability to emotional disorders
| Project/Area Number |
23530957
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Experimental psychology
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| Research Institution | Kagoshima University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
OGAWA Sonoko 筑波大学, 人間総合科学研究科, 教授 (50396610)
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| Project Period (FY) |
2011 – 2013
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| Project Status |
Completed (Fiscal Year 2013)
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| Budget Amount *help |
¥5,200,000 (Direct Cost: ¥4,000,000、Indirect Cost: ¥1,200,000)
Fiscal Year 2013: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2012: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2011: ¥2,600,000 (Direct Cost: ¥2,000,000、Indirect Cost: ¥600,000)
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| Keywords | エストロゲン / 不安障害 / 情動 / 産後うつ / 受容体選択的アゴニスト / マウス / 性腺ホルモン / 多面的行動解析 / 情動の性差 / 恐怖学習 / HPA軸 / 不安 / 神経内分泌 / 選択的エストロゲン受容体アゴニスト / 行動データの多変量解析 |
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| Research Abstract |
Women are more likely than men to suffer from anxiety and depressive disorders, and estrogens are considered to play an important role in the emotional regulation. We demonstrated that the chronic estrogen treatment in higher doses, which were comparable to gestational estrogen levels, enhanced the reactivity of ovariectomized female mice to emotional stimuli. Additionally, the continuous treatment of the selective agonist of ER-alpha increased the anxiety-related behavior, while the treatments of ER-beta agonist merely suppressed that. These results have important implications for neuroendocrinological mechanisms underlying a women's vulnerability to emotional disorders.
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Report
(4 results)
Research Products
(29 results)
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[Journal Article] Differential effects of site-specific knockdown of estrogen receptor α in the medial amygdala, medial preotic area, and ventromedial nucleus of the hypothalamus on the sexual and aggressive behavior of male mice.2013
Author(s)
Sano, K., Tsuda, M.C., Musatov, S., Sakamoto, T., and Ogawa, S.
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Journal Title
European Journal of Neuroscience
Volume: 37
Issue: 8
Pages: 1308-1319
DOI
Related Report
Peer Reviewed
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