| Project/Area Number |
23540156
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
General mathematics (including Probability theory/Statistical mathematics)
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| Research Institution | Josai University |
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Principal Investigator |
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| Co-Investigator(Renkei-kenkyūsha) |
SUZUKI Kazuo 帝京大学, 医学部, 教授 (20192130)
KAWACHI Shoji 国立国際医療研究センター, 手術部, 部長 (60152972)
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| Project Period (FY) |
2011 – 2013
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| Project Status |
Completed (Fiscal Year 2013)
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| Budget Amount *help |
¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Fiscal Year 2013: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000)
Fiscal Year 2012: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000)
Fiscal Year 2011: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000)
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| Keywords | 新型インフルエンザ / 数理モデル / シミュレーション / 白血球減少症 / 急性呼吸促迫症候群 / 数値シミュレーション / 遅延微分方程式 / H5N1 / 浅水波方程式 / ２相流 |
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| Research Abstract |
Background: Fulminant acute respiratory distress syndrome (ARDS) is a major symptom of infection with influenza A/H5N1virus. Patients with influenza A/H5N1 suffer from leukopenia. Nevertheless, the association of cellular injury with leukopenia remains unclear.
Methods and findings: A within-host mathematical model, a system of delay differential equations of virus dynamics and immune response, was applied to ascertain influenza pathogenesis. When leukocytes destroy infected cells, the ratio of leukocyte destruction becomes higher in the case of A/H5N1. Moreover, a comparison of therapies for leukopenia using the model reveals that immunoglobulin therapy is more effective than neuraminidase therapy.
Conclusion: Simulations show that the increased ratio of destruction of leukocytes induces leukopenia and cellular injury of A/H5N1. Furthermore, results of simulations demonstrate the possibility of immunoglobulin therapy for treating leukopenia associated with influenza A/H5N1.
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