Study on Multiplex Imaging in Proton radiography

• Project/Area Number: 23540350
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Particle/Nuclear/Cosmic ray/Astro physics
• Research Institution: Nagaoka University of Technology (2012-2013); National Institute of Technology, Toyama College (2011)
• Principal Investigator: ASO Tsukasa 長岡技術科学大学, 工学部, 准教授 (30290737)
• Co-Investigator(Renkei-kenkyūsha): SASAKI Takashi 高エネルギー加速器研究機構, 計算科学センター, 教授 (50259983) ; NISHIO Teiji 国立がん研究センター, 東病院臨床開発センター, 室長 (40415526) ; TAKADA Eiji 富山高等専門学校, 専攻科, 教授 (00270885)
• Project Period (FY): 2011 – 2013
• Project Status: Completed (Fiscal Year 2013)
• Budget Amount: ¥2,860,000 (Direct Cost: ¥2,200,000、Indirect Cost: ¥660,000); Fiscal Year 2013: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000); Fiscal Year 2012: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000); Fiscal Year 2011: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
• Keywords: 放射線画像 / シミュレーション / Geant4 / 粒子線治療 / 陽子線治療 / 陽子線画像 / モンテカルロ・シミュレーション / 放射線 / モンテカルロ法 / 多重画像 / ラジオグラフィ / 粒子線画像

Research Abstract

We studied about the multiplex proton radiography using a proton accelerator in a proton therapy facility. The study has been performed by using the Monte Carlo simulation based on Geant4 simulation toolkit and the analysis techniques in the High Energy Physics research. The proposed proton imaging system was investigated in terms of possibility, performance, and optimizations.
For the purpose of realizing a simple proton radiography, we utilized the range modulator to vary proton beam energy to emphasis the energy losses of different materials. We evaluated our proposed system in the image quality and the radiation dose in the target. The result shows that our system can obtain proton images with simpler and cheeper equipments than other proton imaging systems.

Research Products

• [Journal Article] Common platform of Monte Carlo dose calculation on universal grid interface with Geant4 based particle therapy simulation framework (2014)
  • Author(s): G Iwai, W Takase, T Aso, Y Watase, T Sasaki, T Akagi, T Yamashita, Y Maeda and T Nishio
  • Journal Title: XVII International Conference on the Use of Computers in Radiation Therapy (ICCR 2013) IOP Publishing, Journal of Physics Volume: 489 Pages: 12001-12001
  • DOI: 10.1088/1742-6596/489/1/012001
  • Peer Reviewed
• [Journal Article] Geant4-based particle therapy simulation framework for verification of dose distributions in proton therapy facilities (2014)
  • Author(s): T. Akagi, T. Aso, G. Iwai, A. Kimura, S. Kameoka, S.B. Lee, Y. Maeda, N. Matsufuji, T. Nishio, C. Omachi, S. Park, T. Sasaki, T. Toshito, W. Takase, T. Yamashita and Y. Watase
  • Journal Title: Progress in Nuclear Science and Technology Volume: (accepted for publication)
  • Peer Reviewed
• [Journal Article] Geant4-based particle therapy simulation framework for verification of dose distributions in proton therapy facilities (2014)
  • Author(s): Takashi Akagi,Tsukasa Aso, Go Iwai, Akinori Kimura, Satoru Kameoka, Se Beyong Lee, Yoshikazu Maeda, Naruhito Matsufuji, Teiji Nishio, Chihiro Omachi, Seyjoon Park, Takashi Sasaki, Toshiyuki Toshito, Wataru Takase, Tomohiro Yamashita and Yoshiyuki Watase
  • Journal Title: Progress in Nuclear Science and Technology Volume: 4 Pages: 1-5
  • Peer Reviewed
• [Journal Article] Extension of the Particle Therapy Simulation Framework to Hospital Information Systems and Multi-grid Environments (2012)
  • Author(s): T. Aso, Y. Maeda, G. Iwai, W. Takase, T. Sasaki, Y. Watase, T. Yamashita, T. Akagi and Y. Nakano
  • Journal Title: IEEE International Conference on Computing and Engineering, IEEE Computer Society Pages: 229-234
  • DOI: 10.1109/iccse.2012.39
  • Peer Reviewed
• [Journal Article] Effect of inhomogeneity in patient’s body on the accuracy of pencil beam algorithm in comparison to Monte Carlo (2012)
  • Author(s): T.Yamashita, T.Akagi, T.Aso, A.Kimura and T.Sasaki
  • Journal Title: Physics in Medicine and Biology Volume: 57 Issue: 22 Pages: 7673-7688
  • DOI: 10.1088/0031-9155/57/22/7673
  • Peer Reviewed
• [Journal Article] The PTSim and TOPAS Projects (2011)
  • Author(s): T. Akagi, T. Aso, B. Faddegon, A. Kimura, N. Matsufuji, T. Nishio, C. Omachi, H. Paganetti, J. Perl, T. Sasaki, D. Sawkey, J. Shumann, J. Shin.T. Toshito, T. Yamashita and H. Yoshida
  • Journal Title: Bringing Geant4 to the Particle Therapy Clinic, Progress in NUCLEAR SCIENCE and TECHNOLOGY Volume: Vol. 2 Pages: 912-917
  • URL: http://www.aesj.or.jp/publication/pnst002/data/912-917.pdf
  • Peer Reviewed
• [Journal Article] The PTSim and TOPAS Projects, Bringing Geant4 to the Particle Therapy Clinic (2011)
  • Author(s): T.AKAGI, T.ASO, B.FADDEGON, A.KIMURA, N.MATSUFUJI, T. NISHIO, C. OMACHI, H. PAGANETTI, J. PERL, T. SASAKI, D. SAWKEY, J. SCHUMANN, J. SHIN, T.TOSHITO, T. YAMASHITA and H.YOSHIDA
  • Journal Title: Progress in Nuclear Science and Technology Volume: Vol. 2 Pages: 912-917
  • Peer Reviewed
• [Presentation] Performance evaluation of Geant4 Based Particle Therapy System Simulation Framework (2014)
  • Author(s): T. Aso, W. Takase, G. Iwai, T. Sasaki, Y. Watase, Y. Maeda, T. Yamashita, T. Akagi, H. Shuuichi, T. Nishio, S.Y. Cai, T.C. Chao, E. Yen, T.H. Wu, Y.T. Lin
  • Organizer: International Symposium on Grids & Clouds 2014
  • Place of Presentation: Academia Sinica, Taipei, Taiwan
• [Presentation] Recent Updates and Plan in Geant4 Based Particle Therapy System Simulation Framework (2013)
  • Author(s): T. Aso, T. Akagi, G. Iwai, A. Kimura, Y. Maeda, N. Mastufuji, T. Nishio, C. Omachi, T. Sasaki, W. Takase, T. Toshito, T. Yamashita, Y. Watase
  • Organizer: IEEE Nuclear Science Symposium and Medical Imaging Conference, Conference Record HT3-8
  • Place of Presentation: COEX, South Korea
• [Presentation] Command-Based Interface of Importance Biasing Technique Using Geant4 for Shielding Applications (2013)
  • Author(s): S. Oyama, T. Aso, M. Shimaoka, K. Amako, H. Yoshida, T. Sasaki
  • Organizer: IEEE Nuclear Science Symposium and Medical Imaging Conference, Conference Record NP02-130
  • Place of Presentation: COEX, South Korea
• [Presentation] Common platform of Monte Carlo dose calculation on universal grid interface with Geant4 based particle therapy simulation framework (2013)
  • Author(s): G. Iwai, W. Takase, T. Aso, Y. Watase, T. Sasaki, T. Akagi, T. Yamashita, Y. Maeda, T. Nishio
  • Organizer: International conference on the use of computers in radiation therapy (ICCR2013)
  • Place of Presentation: Melbourne Convention and Exhibition Centre, Australia
• [Presentation] Geant4 based particle therapy system simulation framework with universal grid interface (2013)
  • Author(s): T. Aso, G. Iwai, T. Wataru, T. Sasaki, Y. Watase, Y. Maeda, T. Yamashita, T. Akagi, T. Nishio
  • Organizer: International Symposium on Grid and Clouds 2013 (ISGC2013)
  • Place of Presentation: Academia Sinica, Taipei
• [Presentation] Recent Updates and Plan in Geant4 Based Particle Therapy System Simulation Framework (2013)
  • Author(s): T.Aso, T.Akagi, G.Iwai, A.Kimura, Y.Maeda, N.Mastufuji, T.Nishi, C.Omachi, T.Sasaki, W.Takase, T.Toshito, T.Yamashita, Y.Watase
  • Organizer: IEEE Nuclear Science Symposium and Medical Imaging Conference
  • Place of Presentation: COEX, Seoul, South Korea
• [Presentation] Command-Based Interface of Importance Biasing Technique Using Geant4 for Shielding Applications (2013)
  • Author(s): S.Oyama, T.Aso, M.Shimaoka, K.Amako, H.Yoshida, T.Sasaki
  • Organizer: IEEE Nuclear Science Symposium and Medical Imaging Conference
  • Place of Presentation: COEX, Seoul, South Korea
• [Presentation] Common platform of Monte Carlo dose calculation on universal grid interface with Geant4 based particle therapy simulation framework (2013)
  • Author(s): G.Iwai, W.Takase, T.Aso, Y.Watase, T.Sasaki, T.Akagi, T.Yamashita, Y.Maeda, T.Nishio
  • Organizer: International conference on the use of computers in radiation therapy (ICCR2013)
  • Place of Presentation: Melnbourne Convention and Exhibition Centre, Australia
• [Presentation] Status of Quality Assurance using Particle Therapy Simulation Framework in Particle Therapy Facility in Japan (2012)
  • Author(s): T. Akagi, T. Yamashita, T. Aso, A. Kimura, S. Kameoka, Y. Maeda, N. Matsufuji, T. Nishio, C. Omachi, T. Sasaki, T. Toshito
  • Organizer: Particle Therapy Workshop in IEEE NSS/MIC Conference
  • Place of Presentation: Anaheim USA
  • Year and Date: 2012-10-28
• [Presentation] A GEANT4 BASED PARTICLE THERAPY SIMULATION FRAMEWORK FOR VERIFICATION OF DOSE DISTRIBUTIONS IN PROTON THERAPY FACILITY (2012)
  • Author(s): T. Akagi, T. Aso, G. Iwai, A. Kimura, S. Kameoka, S.B. Lee, Y. Maeda, N. Matsufuji, T. Nishio, C. Omachi, S. Park, T. Sasaki, T. Toshito, W. Takase, T. Yamashita and Y. Watase
  • Organizer: 12th International Conference on Radiation Shielding, Computational Medical Physics Working Group
  • Place of Presentation: Nara Prefectural New Public Hall, Nara
  • Year and Date: 2012-09-02
• [Presentation] Extension of the Particle Therapy Simulation Framework to Hospital Information Systems and Multi-grid Environments (2012)
  • Author(s): T. Aso, Y. Maeda, G. Iwai, W. Takase, T. Sasaki, Y. Watase, T. Yamashita, T. Akagi and Y. Nakano
  • Organizer: IEEE International Conference on Computing and Engineering, IEEE Computer Society
  • Place of Presentation: Paphos Cyprus
• [Presentation] A Study on Multiplex Proton Imaging Using GEANT4 (2012)
  • Author(s): T. Aso, K. Kawashima, T. Nishio, S.B. Lee and T. Sasaki
  • Organizer: IEEE Nuclear Science Symposium and Medical Imaging Conference, Conference Record
  • Place of Presentation: Anaheim USA
• [Presentation] Application of Particle Therapy Simulation on GRID Environments (2012)
  • Author(s): T. Aso, R. Noto, W. Takase, Y. Watase, G. Iwai and T. Sasaki
  • Organizer: International Symposium on Grids & Clouds 2012
  • Place of Presentation: Taipei(p.222-223)
• [Presentation] Extension of the Particle Therapy Simulation Framework to Hospital Information Systems and Multi-grid Environments (2012)
  • Author(s): Tsukasa Aso, Yoshikazu Maeda, Go Iwai, Wataru Takase, Takashi Sasaki, Yoshiyuki Watase, Tomohiro Yamashita, Takashi Akagi and Yuki Nakano
  • Organizer: IEEE International Conference on Computing and Engineering
  • Place of Presentation: Paphos, Cyprus
• [Presentation] A Study on Multiplex Proton Imaging Using GEANT4 (2012)
  • Author(s): Tsukasa Aso, Kazuki Kawashima, Teiji Nishio, Se Byeong Lee and Takashi Sasaki
  • Organizer: IEEE Nuclear Science Sympposium and Medical Imaging Conference
  • Place of Presentation: Anaheim, USA
• [Presentation] Status of Quality Assurance using Particle Therapy Simulation Framework in Particle Therapy Facility in Japan (2012)
  • Author(s): T. Akagi, T. Yamashita, T.Aso, A.Kimura, S.Kameoka, Y. Maeda, N. Matsufuji, T. Nishio, C.Omachi, T.Sasaki, T.Toshito
  • Organizer: Hadron Therapy Workshop in IEEE Nuclear Science Symposium and Medical Imaging Conference
  • Place of Presentation: Anaheim, USA
• [Presentation] A GEANT4 BASED PARTICLE THERAPY SIMULATION FRAMEWORK FOR VERIFICATION OF DOSE DISTRIBUTIONS IN PROTON THERAPY FACILITY (2012)
  • Author(s): T. Akagi, T.Aso, G. Iwai, A. Kimura, S.Kameoka, S.B.Lee, Y. Maeda, N. Matsufuji, T. Nishio, C.Omachi, S.J.Park, T.Sasaki, T.Toshito, W.Takase, T. Yamashita, Y. Watase, and H. Yoshida
  • Organizer: 12th International Conference on Radiation Shielding, Computational Medical Physics Working Group
  • Place of Presentation: Nara, JAPAN
• [Presentation] シミュレーションによる荷電粒子の特性を利用した陽子線画像取得方法の検討 (2012)
  • Author(s): 川嶋和希,阿蘇司,佐々木節,西尾禎治
  • Organizer: 2012 日本物理学会北陸支部 定例学術講演会
  • Place of Presentation: 金沢大学
• [Presentation] 放射線治療シミュレーションのユーザインターフェース開発と線量分布の検証 (2012)
  • Author(s): 中野雄貴,阿蘇司
  • Organizer: 2012 日本物理学会北陸支部 定例学術講演会
  • Place of Presentation: 金沢大学
• [Presentation] Application of Particle Therapy Simulation on GRID Environments (2012)
  • Author(s): T.Aso, R.Noto, W.Takase, Y.Watase, G.Iwai and T.Sasaki
  • Organizer: International Symposium on Grids & Clouds 2012
  • Place of Presentation: Taipei Taiwan
• [Presentation] RENKEI-NAREGI環境を使った粒子線医療シミュレーション (2012)
  • Author(s): 阿蘇司, 高瀬亘,渡瀬芳之,岩井剛,佐々木節
  • Organizer: e-サイエンス公開シンポジウム REsources liNKage for E-scIence (RENKEI)
  • Place of Presentation: 国立情報学研究所 (東京都)
• [Presentation] Extensions of DICOM Data interface in Particle Therapy Simulation Framework (2011)
  • Author(s): T. Aso, A. Kimura, T. Sasaki
  • Organizer: 6th Japan-Korea Joint Meeting on Medical Physics/11th Asia-Oceania Congress of Medical Physics
  • Place of Presentation: Kyusyu Univ(P-1)
• [Presentation] Particle Therapy Simulation Framework on GRID Environments (2011)
  • Author(s): T. Aso, R. Noto, G. Iwai, T. Sasaki
  • Organizer: 12th IEEE/ACM International Conference on Grid Computing
  • Place of Presentation: (France) Lyon Conference Center
• [Presentation] A GEANT4 Based Particle Therapy Simulation Framework (2011)
  • Author(s): T. Aso, A. Kumura, T. Yamashita, T. Akagi, S. Kameoka, T. Nishio, K. Murakami, C. Omachi, T. Sasaki, K. Amako, H. Yoshida, H. Kurashige
  • Organizer: Particle Therapy Co-Operative Group (PTCOG 50)
  • Place of Presentation: Philadelphia, USA
• [Presentation] A GEANT4 Based Particle Therapy Simulation Framework (2011)
  • Author(s): T.Aso, A.Kumura, T.Yamashita, T.Akagi, S.Kameoka, T.Nishio, K.Murakami, C.Omachi, T.Sasaki, K.Amako, H.Yoshida, H.Kurashige
  • Organizer: Particle Therapy Co-Operative Group (PTCOG 50)
  • Place of Presentation: Philadelphia USA
• [Presentation] Extensions of DICOM Data Interface in Particle Therapy Simulation Framework (2011)
  • Author(s): T.Aso, A.Kimura and T.Sasaki
  • Organizer: 6th Japan-Korea Medical Physics (JKMP), 11th Asia-Oceania Congress of Medical Physics
  • Place of Presentation: Fukuoka JAPAN
• [Presentation] Particle Therapy Simulation Framework on GRID environments (2011)
  • Author(s): T.Aso, R.Noto, G.Iwai, W.Takase, T.Sasaki
  • Organizer: 2011 12th IEEE/ACM International Conference Grid Computing (GRID2011)
  • Place of Presentation: Lyon France
• [Presentation] シミュレーションによる荷電粒子の特性を利用した陽子線画像取得方法の検討 (2011)
  • Author(s): 川嶋和希, 阿蘇司, 佐々木節, 西尾禎治
  • Organizer: 日本物理学会北陸支部 定例学術講演会
  • Place of Presentation: 福井大学(福井県)
• [Presentation] X 線治療での 2 次粒子情報を利用した線量取得方法のシミュレーションによる検討 (2011)
  • Author(s): 中野雄貴, 阿蘇司, 西尾禎治, 佐々木節
  • Organizer: 日本物理学会北陸支部 定例学術講演会
  • Place of Presentation: 福井大学(福井県)
• [Presentation] 臓器物質の割当を考慮した陽子線医療シミュレーションの開発 (2011)
  • Author(s): 坂上和至, 阿蘇司, 谷内飛鳥, 安田真奈美
  • Organizer: 日本物理学会北陸支部 定例学術講演会
  • Place of Presentation: 福井大学(福井県)