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Mechanism of anesthetic action studied by interfacial vibrational spectroscopy

Research Project

Project/Area Number 23550033
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field Physical chemistry
Research InstitutionNational Institute for Materials Science

Principal Investigator

NOGUCHI Hidenori  独立行政法人物質・材料研究機構, 国際ナノアーキテクトニクス研究拠点, MANA研究者 (60374188)

Project Period (FY) 2011 – 2013
Project Status Completed (Fiscal Year 2013)
Budget Amount *help
¥5,330,000 (Direct Cost: ¥4,100,000、Indirect Cost: ¥1,230,000)
Fiscal Year 2013: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2012: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2011: ¥3,510,000 (Direct Cost: ¥2,700,000、Indirect Cost: ¥810,000)
Keywords表面界面物性 / 和周波発生分光法 / 脂質二分子膜 / トレハロース / 原子間力顕微鏡 / 脂質2分子膜 / 和周波発生分光 / 生体分子 / 界面水
Research Abstract

Adsorption behavior of sodium stearate molecules at fused quartz/solution interface was studied by measuring SFG spectra in sodium stearate aqueous solution, followed by under Ar gas, in pure water, and under Ar gas flow again. Strong peaks due to CH stretching of CH3 group appeared under Ar gas flow, showing the presence of the stearic acid monolayer with very high conformational order. However, no SFG signal was detected when it was contact with water, showing that the structure of stearic acid monolayer was totally disordered in water. It was also found that the well ordered stearic acid monolayer was formed only below critical micelle concentration (CMC).
The effect of trehalose on the stability of DMPC bilayer in dry state was also studied by SFG and AFM measurements. It was found that trehalose was effective for stabilizing DMPC bilayer in dry state. Results showed that trehalose was effective for stabilizing DMPC bilayer domain in dry state.

Report

(4 results)
  • 2013 Annual Research Report   Final Research Report ( PDF )
  • 2012 Research-status Report
  • 2011 Research-status Report
  • Research Products

    (38 results)

All 2014 2013 2012 2011 Other

All Journal Article (13 results) (of which Peer Reviewed: 11 results) Presentation (24 results) (of which Invited: 6 results) Remarks (1 results)

  • [Journal Article] Structure of water at zwitterionic copolymer film-liquid water interfaces as examined by the sum frequency generation method2014

    • Author(s)
      T. Kondo, K. Nomura, M. G-Ide, H. Kitano, H. Noguchi, K. Uosaki, Y. Saruwatari
    • Journal Title

      Colloids Surf. B: Biointerfaces

      Volume: Vol. 113 Pages: 361-367

    • Related Report
      2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] Structure of water at zwitterionic copolymer film-liquid water interfaces as examined by the sum frequency generation method.2014

    • Author(s)
      Kondo, T.; Nomura, K.; Gemmei-Ide, M.; Kitano, H.; Noguchi, H.; Uosaki, K.; Saruwatari, Y.
    • Journal Title

      Colloids Surfaces B: Biointerfaces

      Volume: 113 Pages: 361-367

    • DOI

      10.1016/j.colsurfb.2013.08.051

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Structure of Adsorbed Molecular Layer on Fused Quartz Surface Determined Sequentially in Sodium Stearate Solution, Dry Ar, Pure Water, and Dry Ar by Sum Frequency Generation Spectroscopy2013

    • Author(s)
      Y. Zhang, H. Noguchi, S. Ye and K. Uosaki
    • Journal Title

      Surf. Sci

      Volume: Vol.607 Pages: 92-96

    • Related Report
      2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] Humidity Dependent Structure of Water at the Interfaces Between Perfluorosulfonated Ionomer Thin film and Pt and HOPG Studied by Sum Frequency Generation Spectroscopy2013

    • Author(s)
      H. Noguchi, K. Taneda, H. Naohara, K. Uosaki
    • Journal Title

      Electrochemistry Communications

      Volume: 27 Pages: 5-8

    • DOI

      10.1016/j.elecom.2012.10.041

    • Related Report
      2013 Annual Research Report 2012 Research-status Report
    • Peer Reviewed
  • [Journal Article] Structure of Water in the Vicinity of a Zwitterionic Polymer Brush As Examined by Sum Frequency Generation Method2012

    • Author(s)
      Takuya. Kondo, Kouji Nomura, Masanobu Miura, Makoto Gemmei-Ide, Hiromi Kitano, Hidenori Noguchi, Kohei Uosaki, Kohji Ohno, Yoshiyuki Saruwatari
    • Journal Title

      Colloids Surf. B: Biointerfaces

      Volume: Vol. 100, No.1 Pages: 126-132

    • Related Report
      2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] The Structure of Water in the Vicinity of an Amphoteric Polymer Brush As Examined by Sum Frequency Generation Method2012

    • Author(s)
      T. Kondo, M-G. Ide, H. Kitano, K. Ohno, H. Noguchi, and K. Uosaki
    • Journal Title

      Colloids Surf. B: Biointerfaces

      Volume: Vol.91, No. 1 Pages: 215-218

    • Related Report
      2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] Structure of water in the vicinity of a zwitterionic polymer brush as examined by sum frequency generation method.2012

    • Author(s)
      Kondo, T.; Nomura, K.; Murou, M.; Gemmei-Ide, M.; Kitano, H.; Ohno, K.; Noguchi, H.; Uosaki, K.; Saruwatari, Y.
    • Journal Title

      Colloids Surfaces B: Biointerfaces,

      Volume: 100 Pages: 126-132

    • DOI

      10.1016/j.colsurfb.2012.05.008

    • Related Report
      2012 Research-status Report
    • Peer Reviewed
  • [Journal Article] Structure of adsorbed molecular layer on fused quartz surface determined sequentially in sodium stearate solution, dry Ar, pure water, and dry Ar by sum frequency generation spectroscopy2012

    • Author(s)
      Y. Zhang, H. Noguchi, S. Ye, K. Uosaki,
    • Journal Title

      Surface Science

      Volume: 607 Pages: 92-96

    • DOI

      10.1016/j.susc.2012.08.017

    • Related Report
      2012 Research-status Report
    • Peer Reviewed
  • [Journal Article] Sum frequency generation study on the structure of water in the vicinity of an amphoteric polymer brush.2012

    • Author(s)
      Kondo, T.; Gemmei-Ide, T.; Kitano, H.; Ohno, K.; Noguchi, H.; Uosaki, K.
    • Journal Title

      Colloids Surfaces B. Biointerfaces

      Volume: 91 Pages: 215-218

    • DOI

      10.1016/j.colsurfb.2011.11.012

    • Related Report
      2012 Research-status Report
    • Peer Reviewed
  • [Journal Article] Formation Process and Solvent-Dependent Structure of a Polyproline Self-Assembled Monolayer on a Gold Surface2011

    • Author(s)
      Y. Han, H. Noguchi, K. Sakaguchi, and K. Uosaki
    • Journal Title

      Langmuir

      Volume: Vol.27, No. 19 Pages: 11951-11957

    • Related Report
      2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] 和周波発生分光法・赤外分光法-表面振動分光法による生体界面の構造・機能評価2011

    • Author(s)
      野口秀典, 魚崎浩平
    • Journal Title

      オレオサイエンス

      Volume: Vol. 11, No. 6 Pages: 197-203

    • NAID

      130004853388

    • Related Report
      2013 Final Research Report
  • [Journal Article] Formation Process and Solvent Dependent Structure of Polyproline Self-assembled Monolayer on Gold Surface2011

    • Author(s)
      Ying Han, Hidenori Noguchi, Kazuyasu Sakaguchi, and Kohei Uosaki
    • Journal Title

      Langmuir

      Volume: 27 Pages: 11951-11957

    • Related Report
      2011 Research-status Report
    • Peer Reviewed
  • [Journal Article] The Structure of Water in the Vicinity of an Amphoteric Polymer Brush As Examined by Sum Frequency Generation Method2011

    • Author(s)
      Takuya Kondo, Makoto Gemmei-Ide, Hiromi Kitano, Kohji Ohno, Hidenori Noguchi, and Kohei Uosaki
    • Journal Title

      Colloids Surf. B: Biointerfaces

      Volume: 91 Pages: 215-218

    • Related Report
      2011 Research-status Report
  • [Presentation] 界面振動分光法によるソフト界面構造評価2014

    • Author(s)
      野口秀典
    • Organizer
      つくばソフトマター研究会
    • Place of Presentation
      物質・材料研究機構、つくば
    • Related Report
      2013 Annual Research Report
    • Invited
  • [Presentation] Effects of Saccharides on the Stability of Lipid Bilayer in Dry State2013

    • Author(s)
      Y. Zhang, H. Noguchi, and K. Uosaki
    • Organizer
      第33回表面科学学術講演会
    • Place of Presentation
      つくば
    • Related Report
      2013 Final Research Report
  • [Presentation] Study on the Structure of Lipid Membrane by Vibration Spectroscopy2013

    • Author(s)
      Y. Zhang, H. Noguchi, and K. Uosaki
    • Organizer
      Seventh International Conference on Advanced Vibrational Spectroscopy
    • Place of Presentation
      Kobe, Japan
    • Related Report
      2013 Final Research Report
  • [Presentation] Studies on the Role of Trehalose for the Preservation of Bilayer Structure of DMPC in Air2013

    • Author(s)
      Y. Zhang, H. Noguchi, and K. Uosaki
    • Organizer
      日本化学会第93春季年会
    • Place of Presentation
      滋賀
    • Related Report
      2013 Final Research Report
  • [Presentation] Effect of Trehalose on the Stability of Bilayer Structure of DMPC in Dehydration2013

    • Author(s)
      Y. Zhang, H. Noguchi, and K. Uosaki
    • Organizer
      2nd International Conference on Biomaterials Science
    • Place of Presentation
      Tsukuba, Japan
    • Related Report
      2013 Final Research Report
  • [Presentation] Effect of Trehalose on the Stability of Bilayer Structure of DMPC in Dehydration2013

    • Author(s)
      Y. Zhang, H. Noguchi, and K. Uosaki
    • Organizer
      MANA International Symposium 2013
    • Place of Presentation
      Tsukuba, Japan
    • Related Report
      2013 Final Research Report
  • [Presentation] Interfacial Molecular Structure at Bio-Nanointerfaces Studied by Surface Sensitive Vibrational Spectroscopies2013

    • Author(s)
      Y. Zhang, H. Noguchi, and K. Uosaki
    • Organizer
      CRC International Symposium
    • Place of Presentation
      Sapporo, Japan
    • Related Report
      2013 Final Research Report
    • Invited
  • [Presentation] 空気中でのDMPC二分子膜の構造安定化に対するトレハロースの役割2013

    • Author(s)
      Y. Zhang, H. Noguchi, and K. Uosaki
    • Organizer
      日本化学会第93回春季年会
    • Place of Presentation
      立命館大学びわこ・くさつキャンパス
    • Related Report
      2012 Research-status Report
  • [Presentation] Adsorption Behavior of Stearic Acid at Solid/liquid Interface Studied by Sum Frequency Generation Spectroscopy2012

    • Author(s)
      Y. Zhang, H. Noguchi, and K. Uosaki
    • Organizer
      The 5th GCOE International Symposium
    • Place of Presentation
      Sapporo, Japan
    • Related Report
      2013 Final Research Report
  • [Presentation] Adsorption behavior of stearic acid at solid/liquid interface studied by sum frequency generation spectroscopy2012

    • Author(s)
      Y. Zhang, H. Noguchi, and K. Uosaki
    • Organizer
      Softinterface International Mini-Symposium on Biointerface (SIMS 2012)
    • Place of Presentation
      Tsukuba, Japan
    • Related Report
      2013 Final Research Report
  • [Presentation] Adsorption Behavior of Stearate Molecule at Quartz/Water Interface Studied by Sum Frequency Generation Spectroscopy2012

    • Author(s)
      Y. Zhang, H. Noguchi, S. Ye, and K. Uosaki
    • Organizer
      日本化学会第92春季年会 (2012)
    • Place of Presentation
      Yokohama, Japan
    • Related Report
      2013 Final Research Report
  • [Presentation] Interfacial molecular structure at biointerfaces studied by surface sensitive vibrational spectroscopies2012

    • Author(s)
      H. Noguchi, K. Uosaki
    • Organizer
      International Association of Colloid and Interface Scientists 2012
    • Place of Presentation
      仙台国際会議場
    • Related Report
      2012 Research-status Report
  • [Presentation] Biomaterials and functional surfaces studied by in situ surface vibrational spectroscopies2012

    • Author(s)
      H. Noguchi, K. Uosaki
    • Organizer
      The 14th Vibrations at Surfaces (VAS14)
    • Place of Presentation
      神戸ニチイ学館
    • Related Report
      2012 Research-status Report
  • [Presentation] Study on the structure of biointerfaces by sum frequency generation spectroscopy (SFG)2012

    • Author(s)
      Ya Zhang, Hidenori Noguchi, and Kohei Uosaki
    • Organizer
      The 14th Vibrations at Surfaces (VAS14)
    • Place of Presentation
      神戸ニチイ学館
    • Related Report
      2012 Research-status Report
  • [Presentation] Interfacial molecular structure at biointerfaces studied by surface sensitive vibrational spectroscopies2012

    • Author(s)
      H. Noguchi, K. Uosaki
    • Organizer
      ICEAN-2012
    • Place of Presentation
      Mercure Hotel, Brisbane , Australia
    • Related Report
      2012 Research-status Report
    • Invited
  • [Presentation] 和周波発生分光法による高分子薄膜近傍の水の構造についての研究2012

    • Author(s)
      野村浩二、近藤卓也、源明 誠、北野博巳、野口秀典、魚崎浩平、猿渡欣幸
    • Organizer
      第61回高分子学会北陸支部研究発表会
    • Place of Presentation
      福井大学
    • Related Report
      2012 Research-status Report
  • [Presentation] Effect of trehalose on the stability of bilayer in air2012

    • Author(s)
      Y. Zhang, H. Noguchi, and K. Uosaki
    • Organizer
      Hokkaido Uni. - Nanjing Uni. - Seoul National Joint Symposium
    • Place of Presentation
      北海道大学
    • Related Report
      2012 Research-status Report
  • [Presentation] Interfacial molecular structure at biointerfaces studied by surface sensitive vibrational spectroscopies2012

    • Author(s)
      H. Noguchi, K. Uosaki
    • Organizer
      CRC International Symposium "New Challenges on the Bio-interfaces: Structures and Dynamics"
    • Place of Presentation
      北海道大学
    • Related Report
      2012 Research-status Report
    • Invited
  • [Presentation] Study on the structure of lipids on quartz surface by sum frequency generation (SFG) spectroscopy2011

    • Author(s)
      Y. Zhang, H. Noguchi, and K. Uosaki
    • Organizer
      The 28th European Conference on Surface Science
    • Place of Presentation
      Wrocraw, Poland
    • Related Report
      2013 Final Research Report
  • [Presentation] 界面振動分光法によるソフトマテリアル表面の構造と機能のその場追跡2011

    • Author(s)
      野口秀典, 魚崎浩平
    • Organizer
      日本分析化学会第60年会
    • Place of Presentation
      名古屋
    • Related Report
      2013 Final Research Report
    • Invited
  • [Presentation] Biomaterials and functional surfaces studied by in situ surface vibarational spectroscopies2011

    • Author(s)
      H. Noguchi and K. Uosaki
    • Organizer
      The 7th Nanjin-Suzhou-Hokkaido-NIMS/MANA Joint Symposium
    • Place of Presentation
      Suzhou, China
    • Related Report
      2013 Final Research Report
    • Invited
  • [Presentation] 界面振動分光法によるイソシアニド単分子層の構造評価2011

    • Author(s)
      野口秀典、伊藤未希雄、池田勝佳、魚崎浩平
    • Organizer
      第5回分子科学討論会
    • Place of Presentation
      札幌コンベンションセンター
    • Related Report
      2011 Research-status Report
  • [Presentation] 界面振動分光法によるソフトマテリアル表面の構造と機能のその場追跡2011

    • Author(s)
      野口秀典、魚崎浩平
    • Organizer
      日本分析化学会第60年会(招待講演)
    • Place of Presentation
      名古屋大学
    • Related Report
      2011 Research-status Report
  • [Presentation] Biomaterials and functional surfaces studied by in situ surface vibrational spectroscopy2011

    • Author(s)
      H. Noguchi, K.Uosaki
    • Organizer
      The 7th Nanjin-Suzhou-Hokkaido -NIMS/MANA Joint Sympojium, Suzhou(招待講演)
    • Place of Presentation
      Suzhou University
    • Related Report
      2011 Research-status Report
  • [Remarks] ホームページ

    • URL

      http://www.nims.go.jp/nanointerface/

    • Related Report
      2013 Final Research Report

URL: 

Published: 2011-08-05   Modified: 2019-07-29  

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