| Budget Amount *help |
¥5,460,000 (Direct Cost: ¥4,200,000、Indirect Cost: ¥1,260,000)
Fiscal Year 2013: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2012: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2011: ¥3,120,000 (Direct Cost: ¥2,400,000、Indirect Cost: ¥720,000)
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| Research Abstract |
Hetero Diels-Alder reaction of isotellurazoles are recognized as a novel method for the regioselective synthesis of substituted pyridines, and we just attempted the expansion of the new methodology to the short-step synthesis of fused pyridine alkaloid skeletons. After an enormous efforts of our research work, we just attempted and succeeded in the short-step synthesis of fused pyridine alkaloid skeletons by using our original hetero Diels-Alder reaction of isotellurazoles and suitably designed electron-deficient acetylenic dienophiles as the important key step. Furthermore, we could find the subsequent Friedel-Crafts ring closure of the resulting pyridine ring bearing an aryl and ester groups on the suitable positions, and a convenient and short-step synthesis of a few fused pyridine alkaloid skeletons, i.e. b- and d-carbolines, 1- and 4-azafluorenones, 1-azaphenanthrenes, 1-azaanthraquinones, were finally achieved under a rather mild reaction conditions through our methodology.
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