Synthetic and Mechanistic Applications of Asymmetric Oxidation with Chiral Hypervalent Iodine
| Project/Area Number |
23550059
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Organic chemistry
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| Research Institution | University of Hyogo |
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Principal Investigator |
FUJITA Morifumi 兵庫県立大学, 物質理学研究科, 准教授 (00275314)
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| Co-Investigator(Kenkyū-buntansha) |
WAKISAKA Akihiro 独立行政法人産業技術総合研究所, 環境管理技術研究部門, 研究グループ長 (70358365)
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| Project Period (FY) |
2011 – 2013
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| Project Status |
Completed (Fiscal Year 2013)
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| Budget Amount *help |
¥5,330,000 (Direct Cost: ¥4,100,000、Indirect Cost: ¥1,230,000)
Fiscal Year 2013: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2012: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2011: ¥2,990,000 (Direct Cost: ¥2,300,000、Indirect Cost: ¥690,000)
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| Keywords | 超原子価ヨウ素 / 不斉合成 / 光学活性化合物 / 酸化 / 反応中間体 |
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| Research Abstract |
Oxylactonization of ortho-alkenylbenzoates with hypervalent iodine reagent selectively gave 4-oxyisochroman-1-one products. High level of enantioselectivity was achieved using a lactate-based hypervalent iodine reagent for the oxylactonization. In order to demonstrate the expediency of hypervalent iodine-mediated oxylactonization as a unique synthetic strategy, here we disclose a concise entry to 4-oxyisochroman-1-one polyketide metabolites, containing monocerin derivatives and a fusarentin-related natural product.
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Report
(4 results)
Research Products
(60 results)
