Development of Sequential Metathesis of Cyclobutenecarboxylates and Its Application
| Project/Area Number |
23550060
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Organic chemistry
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| Research Institution | Keio University |
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Principal Investigator |
TAKAO Ken-ichi 慶應義塾大学, 理工学部, 准教授 (70287481)
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| Project Period (FY) |
2011 – 2013
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| Project Status |
Completed (Fiscal Year 2013)
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| Budget Amount *help |
¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2013: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2012: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2011: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
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| Keywords | メタセシス / 生物活性天然物 / 不斉全合成 / シクロブテンカルボン酸 / ブテノリド / 全合成 |
|---|
| Research Abstract |
Olefin metathesis is a powerful synthetic tool in modern organic chemistry. Recently, new methods have been developed by combining several metathesis steps into a domino process. In this study, we developed the ring-opening/ring-closing metathesis of cyclobutenecarboxylate derivatives as a novel method for concise access to gamma-butenolides. Furthermore, we achieved the asymmetric total synthesis of the bioactive natural products clavilactones by use of this method.
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Report
(4 results)
Research Products
(13 results)
