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Radiochemical study on effective nuclide probes localized in nasal cavity and tumor tissues, and given high energy transfer on site

Research Project

Project/Area Number 23550072
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field Inorganic chemistry
Research InstitutionKanazawa University

Principal Investigator

AMANO Ryohei  金沢大学, 保健学系, 教授 (30111769)

Co-Investigator(Kenkyū-buntansha) WASHIYAMA Kohshin  金沢大学, 保健学系, 助教 (80313675)
MIYATI Toshiaki  金沢大学, 保健学系, 教授 (80324086)
SHIGA Hideaki  金沢医科大学, 医学部, 准教授 (80436823)
Project Period (FY) 2011-04-28 – 2015-03-31
Project Status Completed (Fiscal Year 2014)
Budget Amount *help
¥5,330,000 (Direct Cost: ¥4,100,000、Indirect Cost: ¥1,230,000)
Fiscal Year 2013: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2012: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2011: ¥2,990,000 (Direct Cost: ¥2,300,000、Indirect Cost: ¥690,000)
Keywords高LET核種 / 壊変系列 / アルファ核種 / 内部被ばく線量 / エネルギー付与 / 鼻腔 / 腫瘍 / 線エネルギー付与 / 壊変エネルギー / 高LET核種 / 動物実験
Outline of Final Research Achievements

To assess a radiation energy trannsfer to olfactory bulb from 201Tl localized in nasal cavity, a new site informatic index of nasal cavity and right/left olfactory bulb was given on a digital phantom, Digimouse, to use Monte Carlo simulation for MIRD internal dose computation. And to compare the energy transfers to tumor tissue by alpha-rays emitted among various heavy nuclides and their chemicals localized at the same place, 227Th and 223Ra in the actinium series, and 225Ac in the neptunium series were focused in terms of labeling procedure of their compounds, and observation of localizing in tumor tissue, were discussed by compareing the isotopes(equal Z nuclides) in uranium series and thorium series.

Report

(5 results)
  • 2014 Annual Research Report   Final Research Report ( PDF )
  • 2013 Research-status Report
  • 2012 Research-status Report
  • 2011 Research-status Report
  • Research Products

    (4 results)

All 2015 2014 2013 2011

All Journal Article (2 results) (of which Peer Reviewed: 2 results) Presentation (2 results)

  • [Journal Article] Assessment of Olfactory Nerve by SPECT-MRI Image with Nasal Thallium-201 Administration in Patients with Olfactory Impairments in Comparison to Healthy Volunteers2013

    • Author(s)
      H Shiga, J Taki, K Washiyama, J Yamamoto, S Kinase, K Okuda, S Kinuya, N Watanabe, H Tonami, K Koshida, R Amano, M Furukawa, T Miwa
    • Journal Title

      Plos one, journal.pone.0029265

      Volume: 8 Pages: 1-8

    • NAID

      120005253903

    • Related Report
      2012 Research-status Report
    • Peer Reviewed
  • [Journal Article] Biological Safety of Nasal Thallium-201 Administration: A Preclinical Study for Olfacto-scintigraphy2011

    • Author(s)
      Washiyama, K., Shiga, H., Hirota, K.
    • Journal Title

      Journal of Radiation Research

      Volume: 52 Issue: 4 Pages: 450-455

    • DOI

      10.1269/jrr.10153

    • NAID

      10029122142

    • ISSN
      0449-3060, 1349-9157
    • Related Report
      2011 Research-status Report
    • Peer Reviewed
  • [Presentation] Development of a 211Rn/211At generator using a wet chemistry approach for targeted alpha therapy applications2015

    • Author(s)
      K. Washiyama, R. Amano, E. Maeda, N. Yamada, T. Taniguchi, A. Yokoyama, I. Nishinaka, A. Toyoshima, H. Makii, K. Hashimoto
    • Organizer
      9th Symposium on Targeted Alpha Therapy
    • Place of Presentation
      Palac Prymasowski, Warsaw Poland
    • Year and Date
      2015-05-20 – 2015-05-21
    • Related Report
      2014 Annual Research Report
  • [Presentation] Evaluation and Optimization of Direct Radioiodination of an ε-Lysyl-3-(Trimethylstannyl)Benzamide Immunoconjugates2014

    • Author(s)
      Kohshin Washiyama, Sture Lindegren, Yuriko Hiramatsu, Emma Aneheim, and Ryohei Amano
    • Organizer
      27th Annual Congress of the European Association of Nuclear Medicine (EANM’14)
    • Place of Presentation
      Svenska Massan, Gothenburg, Sweden
    • Year and Date
      2014-10-18 – 2014-10-22
    • Related Report
      2014 Annual Research Report

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Published: 2011-08-05   Modified: 2019-07-29  

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