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Construction of a highly sensitive electrochemical detector on a microchip device with an integrated single comb-like array electrode and its application

Research Project

Project/Area Number 23550087
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field Analytical chemistry
Research InstitutionHokkaido University

Principal Investigator

ISHIDA Akihiko  北海道大学, 工学(系)研究科(研究院), 助教 (20312382)

Project Period (FY) 2011 – 2013
Project Status Completed (Fiscal Year 2013)
Budget Amount *help
¥5,590,000 (Direct Cost: ¥4,300,000、Indirect Cost: ¥1,290,000)
Fiscal Year 2013: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2012: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2011: ¥3,510,000 (Direct Cost: ¥2,700,000、Indirect Cost: ¥810,000)
Keywords電気化学検出 / くし形電極 / チャンネルフローセル / 液体クロマトグラフィー / チップ分析 / 微小電極 / マイクロ流体 / HPLC
Research Abstract

In this study, a single comb-like electrode was studied, which was formed by arranging a number of microelectrodes at a given spacing. A thorough examination of the shape factors of the electrode led to electrochemical detection of more trace amounts of substances. High sensitivity has been achieved by the electrode alone with a characteristic shape. The electrode has good utility because a wide variety of target substances can be detected and the detection can be performed with a relatively cheap measuring apparatus. This electrode is expected to be used as a powerful detector for microfluidic analysis devices possibly demanded in a field of clinical diagnosis in near future.

Report

(4 results)
  • 2013 Annual Research Report   Final Research Report ( PDF )
  • 2012 Research-status Report
  • 2011 Research-status Report
  • Research Products

    (28 results)

All 2013 2012 2011 Other

All Journal Article (3 results) (of which Peer Reviewed: 2 results) Presentation (23 results) Remarks (2 results)

  • [Journal Article] A Single Comb-like Electrode Array for Highly Sensitive Electrochemical Detection of Catecholamine in Microfluidic Device2013

    • Author(s)
      Jun Sekiya, Tatsuya Tanaka, Satoshi Yokogawa, Akihiko Ishida, Hirofumi Tani, Manabu Tokeshi
    • Journal Title

      Proceedings of 2013 International Conference on Microtechnologies in Medicine and Biology

      Pages: 50-51

    • Related Report
      2013 Annual Research Report 2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] Portable Liquid Chromatography System Based on Battery-powered Electroosomotic Pump and Microchip with Packed Column and Electrochemical Detector2012

    • Author(s)
      Akihiko Ishida, Takehiro Fujimoto, Satoshi Yokogawa, Hirofumi Tani, Manabu Tokeshi, Ichiro Yanagisawa
    • Journal Title

      Proceedings of MicroTAS 2012 conference

      Pages: 1183-1185

    • Related Report
      2013 Final Research Report 2012 Research-status Report
    • Peer Reviewed
  • [Journal Article] ポリスチレン基板に作製した単一くし形微小電極の応答特性の評価とマイクロチップ分析への応用2011

    • Author(s)
      横川理史, 田中達也, 谷 博文, 石田晃彦
    • Journal Title

      Chemical Sensors Supplement B

      Volume: 27 Pages: 125-127

    • Related Report
      2013 Final Research Report 2011 Research-status Report
  • [Presentation] Highly Sensitive Electrochemical Detector for a Miniaturized Liquid Chromatography System with a Microfluidic Chip2013

    • Author(s)
      Akihiko Ishida, Satoshi Yokogawa, Tatsuya Tanaka, Hirofumi Tani, Manabu Tokeshi
    • Organizer
      39th International Symposium on High Performance Liquid Phase Separations and Related Techniques (HPLC2013)
    • Place of Presentation
      Amsterdam RAI (オランダ)
    • Year and Date
      2013-06-17
    • Related Report
      2013 Final Research Report
  • [Presentation] A SINGLE COMB-LIKE ELECTRODE ARRAY FOR HIGHLY SENSITIVE ELECTROCHEMICAL DETECTION OF CATECHOLAMINE IN MICROFLUIDIC DEVICE2013

    • Author(s)
      Jun Sekiya, Tatsuya Tanaka, Satoshi Yokogawa, Akihiko Ishida, Hirofumi Tani, Manabu Tokeshi
    • Organizer
      2013 International Conference on Microtechnologies in Medicine and Biology
    • Place of Presentation
      Marina del Rey Marriott (USA)
    • Year and Date
      2013-04-10
    • Related Report
      2013 Final Research Report
  • [Presentation] CONSTRUCTION OF MICROFLUIDIC ELECTROCHEMICAL CELL FOR ANALYSIS OF NEUROTRANSMITTER2013

    • Author(s)
      Jun Sekiya, Satoshi Yokogawa, Tatsuya Tanaka, Akihiko Ishida, Hirifumi Tani, Manbu Tokeshi
    • Organizer
      RSC Tokyo International Conference 2013 - Analytical Biochemistry & Biophysics -, International Session, JASIS Conference
    • Place of Presentation
      幕張メッセ(千葉市)
    • Related Report
      2013 Annual Research Report
  • [Presentation] 単一くし形電極に基づくマイクロ流体電気化学検出システムの構築2012

    • Author(s)
      石田 晃彦, 横川 理史, 谷 博文
    • Organizer
      日本化学会第92春季年会
    • Place of Presentation
      慶應義塾大学日吉キャンパス(横浜市)
    • Year and Date
      2012-03-26
    • Related Report
      2013 Final Research Report
  • [Presentation] PORTABLE LIQUID CHROMATOGRAPHY SYSTEM BASED ON BATTERY-POWERED ELECTROOSOMOTIC PUMP AND MICROCHIP WITH PACKED COLUMN AND ELECTROCHEMICAL DETECTOR2012

    • Author(s)
      Akihiko Ishida, Takehiro Fujimoto, Satoshi Yokogawa, Hirofumi Tani, Manabu Tokeshi, Ichiro Yanagisawa
    • Organizer
      The 16th International Conference on Miniaturized Systems for Chemistry and Life Sciences (MicroTAS2012)
    • Place of Presentation
      沖縄コンベンションセンター (宜野湾市)
    • Related Report
      2013 Final Research Report
  • [Presentation] Miniaturized Liquid Chromatography System Based on an Electroosomotic Pump and a Microfluidic Chip with Column and Detector2012

    • Author(s)
      Akihiko Ishida, Ichiro Yanagisawa
    • Organizer
      38th International Symposium on High Performance Liquid Phase Separations and Related Techniques
    • Place of Presentation
      Anaheim Marriott (USA)
    • Related Report
      2012 Research-status Report
  • [Presentation] PORTABLE LIQUID CHROMATOGRAPHY SYSTEM BASED ON BATTERY-POWERED ELECTROOSOMOTIC PUMP AND MICROCHIP WITH PACKED COLUMN AND ELECTROCHEMICAL DETECTOR2012

    • Author(s)
      Akihiko Ishida, Takehiro Fujimoto, Satoshi Yokogawa, Hirofumi Tani, Manabu Tokeshi, Ichiro Yanagisawa
    • Organizer
      The 16th International Conference on Miniaturized Systems for Chemistry and Life Sciences (MicroTAS2012)
    • Place of Presentation
      沖縄コンベンションセンター (宜野湾市)
    • Related Report
      2012 Research-status Report
  • [Presentation] 電気浸透流ポンプとマイクロ流体チップに基づくポータブルな液体クロマトグラフィーシステムの開発2012

    • Author(s)
      石田晃彦,柳澤一郎
    • Organizer
      第72回分析化学討論会
    • Place of Presentation
      鹿児島大学 (鹿児島市)
    • Related Report
      2012 Research-status Report
  • [Presentation] マイクロチップ液体クロマトグラフィーのための固定相粒子充填法の開発とそのカラム性能の評価2012

    • Author(s)
      富士本雄大,谷 博文,石田晃彦
    • Organizer
      化学系学協会北海道支部 2012年冬季研究発表会
    • Place of Presentation
      北海道大学(札幌市)
    • Related Report
      2011 Research-status Report
  • [Presentation] アミノ酸の電気化学検出マイクロ分析システムのための誘導体化リアクターの開発2012

    • Author(s)
      佐々木俊輔,谷 博文,石田晃彦
    • Organizer
      化学系学協会北海道支部 2012年冬季研究発表会
    • Place of Presentation
      北海道大学(札幌市)
    • Related Report
      2011 Research-status Report
  • [Presentation] 微小流体分析デバイスの高感度アンペロメトリックフローセルのための電極および流路デザイン2012

    • Author(s)
      横川理史,谷 博文,石田晃彦
    • Organizer
      化学系学協会北海道支部 2012年冬季研究発表会
    • Place of Presentation
      北海道大学(札幌市)
    • Related Report
      2011 Research-status Report
  • [Presentation] 単一くし形電極に基づくマイクロ流体電気化学検出システムの構築2012

    • Author(s)
      石田 晃彦,横川 理史,谷 博文
    • Organizer
      日本化学会第92春季年会
    • Place of Presentation
      慶應義塾大学日吉キャンパス(横浜市)
    • Related Report
      2011 Research-status Report
  • [Presentation] ポリスチレン基板に作製した単一くし形電極の応答特性の評価とマイクロチップ分析への応用2011

    • Author(s)
      横川 理史, 田中 達也, 谷 博文, 石田 晃彦
    • Organizer
      第52回化学センサ研究発表会・2011年電気化学秋季年会
    • Place of Presentation
      朱鷺メッセ・新潟コンベンションセンター(新潟市)
    • Year and Date
      2011-09-11
    • Related Report
      2013 Final Research Report
  • [Presentation] Development of a Highly Sensitive Electrochemical Flow-through Cell with a Single Digitated Electrode for Microfluidic Analytical Systems2011

    • Author(s)
      横川 理史,田中 達也,谷 博文,石田 晃彦
    • Organizer
      IUPAC2011国際分析科学会議
    • Place of Presentation
      国立京都国際会館(京都市)
    • Related Report
      2011 Research-status Report
  • [Presentation] 電気化学微小分析デバイスのための流体力学的フォーカシングシステムの設計と評価2011

    • Author(s)
      阿部礼佳,谷 博文,石田晃彦
    • Organizer
      北海道支部2011年夏季研究発表会
    • Place of Presentation
      室蘭工業大学(室蘭市)
    • Related Report
      2011 Research-status Report
  • [Presentation] ポリスチレン基板に作製した単一くし形電極の応答特性の評価とマイクロチップ分析への応用2011

    • Author(s)
      横川 理史,田中 達也,谷 博文,石田 晃彦
    • Organizer
      第52回化学センサ研究発表会・2011年電気化学秋季年会
    • Place of Presentation
      朱鷺メッセ・新潟コンベンションセンター(新潟市)
    • Related Report
      2011 Research-status Report
  • [Presentation] マイクロチップ液体クロマトグラフィーのための充填カラムの開発2011

    • Author(s)
      富士本雄大,谷 博文,石田晃彦
    • Organizer
      日本分析化学会第60年会
    • Place of Presentation
      名古屋大学(名古屋市)
    • Related Report
      2011 Research-status Report
  • [Presentation] アミノ酸分析の電気化学検出マイクロチップシステムのためのプレカラム誘導体化リアクター2011

    • Author(s)
      佐々木俊輔,谷 博文,石田晃彦
    • Organizer
      第31回キャピラリー電気泳動シンポジウム
    • Place of Presentation
      鶴岡メタボロームキャンパス(鶴岡市)
    • Related Report
      2011 Research-status Report
  • [Presentation] A SINGLE COMB-LIKE ELECTRODE ARRAY FOR HIGHLY SENSITIVE ELECTROCHEMICAL DETECTION OF CATECHOLAMINE IN MICROFLUIDIC DEVICE

    • Author(s)
      Jun Sekiya, Tatsuya Tanaka, Satoshi Yokogawa, Akihiko Ishida, Hirofumi Tani, Manabu Tokeshi
    • Organizer
      2013 International Conference on Microtechnologies in Medicine and Biology
    • Place of Presentation
      Marina del Rey Marriott (USA)
    • Related Report
      2013 Annual Research Report
  • [Presentation] Highly Sensitive Electrochemical Detector for a Miniaturized Liquid Chromatography System with a Microfluidic Chip

    • Author(s)
      Akihiko Ishida, Satoshi Yokogawa, Tatsuya Tanaka, Hirofumi Tani, Manabu Tokeshi
    • Organizer
      39th International Symposium on High Performance Liquid Phase Separations and Related Techniques (HPLC2013)
    • Place of Presentation
      Amsterdam RAI (オランダ)
    • Related Report
      2013 Annual Research Report
  • [Presentation] 単一くし形電極を有するマイクロ流体フローセルの評価

    • Author(s)
      関谷 潤,横川理史,石田晃彦,谷 博文,渡慶次 学
    • Organizer
      第31回九州分析化学若手の会夏季セミナー
    • Place of Presentation
      長崎ホテル 清風(長崎市)
    • Related Report
      2013 Annual Research Report
  • [Presentation] ポータブル液体クロマトグラフィーシステムの開発

    • Author(s)
      石田晃彦
    • Organizer
      第 51 回フローインジェクション分析講演会
    • Place of Presentation
      熊本大学工学部百周年記念館(熊本市)
    • Related Report
      2013 Annual Research Report
  • [Presentation] オンチップ電気化学検出のための高性能電極システムの構築

    • Author(s)
      関谷潤,横川理史,田中達也,石田晃彦,谷博文,渡慶次学
    • Organizer
      化学とマイクロ・ナノシステム学会第28回研究会
    • Place of Presentation
      イーグレひめじ あいめっせホール(姫路市)
    • Related Report
      2013 Annual Research Report
  • [Remarks]

    • URL

      http://labs.eng.hokudai.ac.jp/labo/tokeshi_lab/?post_type=research

    • Related Report
      2013 Final Research Report
  • [Remarks] 生物計測化学研究室ホームページ

    • URL

      http://labs.eng.hokudai.ac.jp/labo/tokeshi_lab/?post_type=research

    • Related Report
      2013 Annual Research Report

URL: 

Published: 2011-08-05   Modified: 2019-07-29  

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