| Budget Amount *help |
¥5,330,000 (Direct Cost: ¥4,100,000、Indirect Cost: ¥1,230,000)
Fiscal Year 2013: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000)
Fiscal Year 2012: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
Fiscal Year 2011: ¥2,470,000 (Direct Cost: ¥1,900,000、Indirect Cost: ¥570,000)
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| Research Abstract |
The development of environmentally benign transformation is one of the most important subjects in organic synthesis. Although asymmetric organocatalysis has been recognized as one of them to serve optically active compounds efficiently, there has been still limited in the applicability and generality. In the present study, we developed asymmetric rearrangement reaction based on the design of organo allylation reagents. We found that Brønsted acid promoted 1,3-rearrangement reaction of homoallyl amines or homoallylic imines to serve optically active 4,4-substituted homoallyl amines in excellent chirality transfer ratio. To the best our knowledge, this is the first example of the asymmetric 1,3-rearragement for homoallyl amines synthesis.
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