| Project/Area Number |
23550116
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Synthetic chemistry
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| Research Institution | The University of Tokyo |
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Principal Investigator |
KUDO Kazuaki 東京大学, 生産技術研究所, 教授 (80251669)
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| Co-Investigator(Kenkyū-buntansha) |
AKAGAWA Kengo 東京大学, 生産技術研究所, 助教 (60548733)
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| Project Period (FY) |
2011 – 2013
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| Project Status |
Completed (Fiscal Year 2013)
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| Budget Amount *help |
¥5,590,000 (Direct Cost: ¥4,300,000、Indirect Cost: ¥1,290,000)
Fiscal Year 2013: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2012: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000)
Fiscal Year 2011: ¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
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| Keywords | 有機分子触媒 / 不斉触媒 / ペプチド / 二次構造 / ペプチド触媒 / 立体選択的反応 / ライブラリ / ターン構造 / ヘリックス構造 / 有機触媒 / 不斉合成 / コンビナトリアル化学 |
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| Research Abstract |
The seemingly not catalytically active helical part of the chimeric peptide catalyst was found to play a role to stabilize the catalytically active turn motif by means of 2D-NMR measurement. Screening for optimal peptide catalyst was performed on the basis of combinatorial approach, and a peptide with hitherto unknown sequence was found. It was anticipated that the newly found peptide catalyst might realize the enantioselectivity not by simple steric control but by other guiding principle. For other reactions catalyzed by chimeric peptides, 1) a conjugate addition to beta-disubstituted alpha,beta-unsaturated aldehydes and 2) kinetic resolution of racemic planar chiral compounds were successfully developed.
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