Allylic and propargylic substitutions using the picolinoxy leaving group and application to organic synthesis
| Project/Area Number |
23550119
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Synthetic chemistry
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| Research Institution | Tokyo Institute of Technology |
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Principal Investigator |
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| Project Period (FY) |
2011 – 2013
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| Project Status |
Completed (Fiscal Year 2013)
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| Budget Amount *help |
¥5,330,000 (Direct Cost: ¥4,100,000、Indirect Cost: ¥1,230,000)
Fiscal Year 2013: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2012: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2011: ¥2,470,000 (Direct Cost: ¥1,900,000、Indirect Cost: ¥570,000)
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| Keywords | アリル化反応 / 銅試薬 / アセチレン銅試薬 / ピコリン酸アリルエステル / リン酸アリルエステル / 第4級炭素構築 / シクロバクチオール / ジャスモン酸 / ピコリン酸アリル / ピコリン酸プロパルギル / 2,6-ジ置換シクロヘキサノン / アリルピコレート / ピコリン酸脱離基 / 光学活性 / アナストレフィン / プロパルギルエステル / 芳香族Grignard試薬 / プロスタグランジン |
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| Research Abstract |
Allylic substitution of secondary allylic picolinates with copper reagents were investigated to establish methods for: (1) construction of quaternary carbon center; (2) synthesis of anti inflammatory cyclobakuchiols; (3) synthesis of trans 2,6-disubstituted cyclohexanones; (4) introduction of acetylene on a cyclopentane ring; (5) Pd-catalyzed allylic substitution of 1,3-disubstituted secondary allylic esters with ketone enolates.
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Report
(4 results)
Research Products
(41 results)
