Palladium-catalyzed synthesis of fluorine-containing chiral allylic amines by a new stereocontrol
Project/Area Number |
23550123
|
Research Category |
Grant-in-Aid for Scientific Research (C)
|
Allocation Type | Multi-year Fund |
Section | 一般 |
Research Field |
Synthetic chemistry
|
Research Institution | Nihon University (2012-2013) Tottori University (2011) |
Principal Investigator |
|
Project Period (FY) |
2011 – 2013
|
Project Status |
Completed (Fiscal Year 2013)
|
Budget Amount *help |
¥5,200,000 (Direct Cost: ¥4,000,000、Indirect Cost: ¥1,200,000)
Fiscal Year 2013: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2012: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2011: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
|
Keywords | パラジウム / アリル位アミノ化 / 不斉合成 / フッ素 / アリルアミン / トリフルオロメチル基 / 動的速度論的光学分割 / パラジウム触媒 / エナンチオ選択性 / 銀塩 / 位置選択性 / アミノ化 / カチオン性 |
Research Abstract |
The palladium-catalyzed regio- and enantioselective allylic amination of the trifluoromethyl group substituted racemic and unsymmetrical 1,3-disubstituted allylic esters has been accomplished. The enantioselective formation of the a-type allylic amines was attained by the dynamic kinetic asymmetric transformation (DYKAT).
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Report
(4 results)
Research Products
(22 results)