Development and application of stable spin-label reagent for in vivo analysis
| Project/Area Number |
23550187
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Chemistry related to living body
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| Research Institution | Yamagata University |
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Principal Investigator |
HATANO Bunpei 山形大学, 理工学研究科, 准教授 (20333990)
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| Co-Investigator(Renkei-kenkyūsha) |
OGATA Tateaki 山形大学, 大学院理工学研究科, 名誉教授 (50091830)
KIJIMA Tatsuro 山形大学, 大学院理工学研究科, 准教授 (50272084)
ITO Tomohiro 山形大学, 大学院理工学研究科, 准教授 (60361276)
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| Project Period (FY) |
2011 – 2013
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| Project Status |
Completed (Fiscal Year 2013)
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| Budget Amount *help |
¥5,330,000 (Direct Cost: ¥4,100,000、Indirect Cost: ¥1,230,000)
Fiscal Year 2013: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2012: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2011: ¥2,860,000 (Direct Cost: ¥2,200,000、Indirect Cost: ¥660,000)
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| Keywords | スピンラベル剤 / 農薬ミュータント / ESR / 経時変化追跡法 / 無侵襲計測 / 農薬ニュータント |
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| Research Abstract |
We developed new spin-label reagents based of isoindole framework bearing bulky alkyl groups near nitroxyl radical. The spin labels showed strong resistance against the reduction with L-sodium ascorbate. We also developed the synthesis method of agricultural chemicals bearing spin-labels using click reaction.
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Report
(4 results)
Research Products
(30 results)
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[Journal Article] Enantioresolution of 2,2'-bis(diphenylphosphino)-1,1'-binaphthyl oxide using inclusion complex with chiral 2,2'-dihydroxy-1,1'-binaphtyl2012
Author(s)
Bunpei Hatano, Kazuyuki Hashimoto, Hiroshi Katagiri, Tatsuro Kijima, Satoshi Murakami, Shigeru Matsuba, Miho Kusakari
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Journal Title
Journal of Organic Chemistry
Volume: 77
Issue: 7
Pages: 3595-3597
DOI
Related Report
Peer Reviewed
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[Journal Article] Enantioresolution of 2,2'-bis(diphenylphosphino)-1,1'-bi naphthyl oxide using inclusion com- plex with chiral 2,2'-di- hydroxy-1,1'-binaphtyl2011
Author(s)
B. Hatano, K. Hashimoto, H. Katagiri, T, Kijima, S. Murakami, S. Matsuba, M. Kusakari
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Journal Title
Related Report
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[Presentation] Synthesis of TEIO derivative and ESR study2013
Author(s)
Y. Saito, T. Kijima, M. Kusakari, S. Murakami, S. Matsuba, B. Hatano
Organizer
International Symposium for the 70th Anniversary of the Tohoku Branch of the Chemical Society of Japan
Place of Presentation
Kawauchi-Kita Campus, Tohoku University
Related Report
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