| Budget Amount *help |
¥5,460,000 (Direct Cost: ¥4,200,000、Indirect Cost: ¥1,260,000)
Fiscal Year 2013: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2012: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2011: ¥3,380,000 (Direct Cost: ¥2,600,000、Indirect Cost: ¥780,000)
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| Research Abstract |
Many G-protein coupled receptors exist as homo-dimers and heterodimers, but also that their dimeric assembly could have important functional roles. To understand the structure and biological roles of dimeric states of formyl peptide receptors, dimeric peptides with subtype selective ligands were synthesized. From the results of biological assays, dimers play a role in binding to the two distinct binding sites.
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