| Budget Amount *help |
¥5,330,000 (Direct Cost: ¥4,100,000、Indirect Cost: ¥1,230,000)
Fiscal Year 2013: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2012: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2011: ¥2,730,000 (Direct Cost: ¥2,100,000、Indirect Cost: ¥630,000)
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| Research Abstract |
In this study we have developed methods for the introduction of transition metal compounds as cofactors into the antigen-combining site to function as metal enzymes. Because transition metal catalysis catalyzes a variety of chemical transformations, the introduction of a transition metal into the antigen-combining site widen the versatility of antibody catalysts. We have studied two methods to introduce the transition metal to the antigen-combining site, (1) immunization of the transition-state analog which contains transition metal compounds, and (2) introduction of transition metal containing artificial cofactors into the antigen-combining site by using the technique of holoabzyme.
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