| Project/Area Number |
23550198
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Chemistry related to living body
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| Research Institution | Tokai University |
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Principal Investigator |
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| Project Period (FY) |
2011 – 2013
|
| Project Status |
Completed (Fiscal Year 2013)
|
| Budget Amount *help |
¥5,200,000 (Direct Cost: ¥4,000,000、Indirect Cost: ¥1,200,000)
Fiscal Year 2013: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2012: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2011: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
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| Keywords | セレン / 抗酸化剤 / アミノ酸 / タンパク質 / フォールディング / 触媒反応 / 不斉合成 |
|---|
| Research Abstract |
Organoselenium compounds have been widely utilized as useful reagents in the field of organic synthesis. However, aliphatic selenium compounds, which do not have a direct chemical bond between the selenium atom and a benzene ring, are generally unstable and hence have not yet been studied extensively. In this study, we succeeded in the synthesis of stable aliphatic selenium compounds by applying a sugar-like cyclic or amino acid skeleton. Moreover, it was demonstrated that the synthesized compounds are usable as enzymatic models, antioxidants, asymmetric catalysts, and folding reagents of proteins in various research fields, such as chemistry, medicinal chemistry, and biochemistry.
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