| Project/Area Number |
23550199
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Chemistry related to living body
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| Research Institution | Tokyo University of Science |
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Principal Investigator |
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| Project Period (FY) |
2011 – 2013
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| Project Status |
Completed (Fiscal Year 2013)
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| Budget Amount *help |
¥5,200,000 (Direct Cost: ¥4,000,000、Indirect Cost: ¥1,200,000)
Fiscal Year 2013: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2012: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2011: ¥2,600,000 (Direct Cost: ¥2,000,000、Indirect Cost: ¥600,000)
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| Keywords | β－グルカン / キトサン / カードラン / ヨウ素錯体 / 高分子ミセル / 環境応答性 / 薬物キャリヤー / β-グルカン / 高分子ナノゲル |
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| Research Abstract |
Beta-glucans such as chitosan and curdlan have an effective physiological activity. However, a significant drawback of insolubility in neutral water exists for the practical use of their beta-glucans. In order to develop promising medical-nanomaterials working as drug carrier with their beta-glucans involved in overcoming the drawback, we have intended the graft (g) and block (b) type-copolymerization of their beta-glucans with hydrophilic and biocompatible polymers, polyethylene glycol and temperature-responsive poly(N-isopropylacrylamide). As a result, some g- and b-type copolymers soluble in neutral aqueous solution were succeed to be synthesized, and then, the molecular assembly complexation of the copolymers with iodine gave rise to assume environmentally-responsive nano-particles with a size of ca. 50-100 nm, containing iodine in internal aggregated-core. Consequently, the nano-particles comprising of the beta-glucans and iodine was expected to be a promising drug-carrier.
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