| Project/Area Number |
23550200
|
|---|
| Research Category |
Grant-in-Aid for Scientific Research (C)
|
| Allocation Type | Multi-year Fund |
|---|
| Section | 一般 |
|---|
| Research Field |
Chemistry related to living body
|
|---|
| Research Institution | Ryukoku University |
|---|
Principal Investigator |
|
|---|
| Project Period (FY) |
2011 – 2013
|
| Project Status |
Completed (Fiscal Year 2013)
|
| Budget Amount *help |
¥5,720,000 (Direct Cost: ¥4,400,000、Indirect Cost: ¥1,320,000)
Fiscal Year 2013: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000)
Fiscal Year 2012: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2011: ¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000)
|
|---|
| Keywords | ペプチド / 自己集合化 / フェリチン / ナノファイバー / ペプチド集合体 |
|---|
| Research Abstract |
Ferritin is a spherical and iron-preservation protein to control iron ion concentration in biosystems. The inner and outer diameters of ferritin shell are about 7 and 12 nm, respectively. In addition, the internal cavity takes various metal particles. Using this property, synthesis of nanoperticles with narrow size distribution is performed to develop a new-type electronic device. However, photolithography is necessary to align ferritins within a nano-scaled area. Meanwhile, peptides form self-assembled nanoarchitechtures depending on their amino acid sequences. If ferritins are aligned along self-assembled peptide nanoarchitechtures, it is possible to realize low cost, simple and easy production of ferritin-based nanodevices. We designed and synthesized self-assembled beta-sheet-forming peptide fibrous formations and successfully aligned ferritins and their derivatives along the peptide nanofibers even in a low density.
|
