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The study of the generating and affecting of the high intensity burst pulse electromagnetic wave for the cancer treatment method using the ultra-short pulsed high electric field

Research Project

Project/Area Number 23560312
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field Power engineering/Power conversion/Electric machinery
Research InstitutionYamagata University

Principal Investigator

MINAMITANI Yasushi  山形大学, 理工学研究科, 准教授 (10323172)

Project Period (FY) 2011 – 2013
Project Status Completed (Fiscal Year 2013)
Budget Amount *help
¥5,200,000 (Direct Cost: ¥4,000,000、Indirect Cost: ¥1,200,000)
Fiscal Year 2013: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2012: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2011: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Keywordsがん治療 / アポトーシス / 超短パルス高電界 / パルス電磁波 / SOSダイオード / 高周波バーストパルス / 共振伝送線路 / 磁気スイッチ / 出芽酵母 / HeLa細胞 / 非線形伝送線路 / 磁気共鳴 / 分散 / がん細胞
Research Abstract

This work focuses on the design of a compact high power pulsed electromagnetic wave generator using a nanosecond pulsed power generator to apply a high-intensity electric field for a cancer treatment. In previous study, since the output voltage waveform of the pulsed power generator was damping oscillation, the duration of the burst pulse was under 100 ns. So the generator uses a magnetic switch instead of the gap switch and uses a SOS diode with current cutoff time of nanoseconds. The cluster pulse has 6 burst pulses that continue for 3000 ns. And the effect of frequency of burst pulse high electric field on HeLa cells has been clarified.

Report

(4 results)
  • 2013 Annual Research Report   Final Research Report ( PDF )
  • 2012 Research-status Report
  • 2011 Research-status Report
  • Research Products

    (31 results)

All 2014 2013 2012 2011 Other

All Journal Article (12 results) (of which Peer Reviewed: 1 results) Presentation (19 results)

  • [Journal Article] Development of a High Frequency Cluster Burst Pulse Generator Based on a SOS Diode Using Transmission Line Resonant for Bioelectrics Applications2014

    • Author(s)
      Daisuke Matsukubo, Yasushi Minamitani
    • Journal Title

      2013 IEEE Pulsed Power Conference Record

      Volume: (CD-ROM)

    • Related Report
      2013 Final Research Report
  • [Journal Article] Development of a RF burst pulse generator using a non-linear transmission line for cancer treatment2013

    • Author(s)
      Yuichi Abe, Yasushi Minamitani
    • Journal Title

      Proceedings of the IEEE 2012 Power Modulator Conference

      Volume: (CD-ROM)

    • NAID

      10030604637

    • Related Report
      2013 Final Research Report 2012 Research-status Report
    • Peer Reviewed
  • [Journal Article] DEVELOPMENT OF A HIGH FREQUENCY CLUSTER BURST PULSE GENERATOR BASED ON A SOS DIODE USING TRANSMISSION LINE RESONANT FOR BIOELECTRICS APPLICATIONS2013

    • Author(s)
      Daisuke Matsukubo, Yasushi Minamitani
    • Journal Title

      The 19th IEEE International Pulsed Power Conference

      Volume: CFP13PPC-DVD Pages: 597-601

    • Related Report
      2013 Annual Research Report
  • [Journal Article] Investigation of Frequency Response of Apoptosis Induction to Budding Yeast by Burst Pulse Electric Field for Cancer Treatment2013

    • Author(s)
      K. Tamura, R. Kageyama, Y. Minamitani
    • Journal Title

      The 19th IEEE International Pulsed Power Conference

      Volume: CFP13PPC-DVD Pages: 908-913

    • Related Report
      2013 Annual Research Report
  • [Journal Article] パルス電界の周波数による細胞へのアポトーシス誘導状況の蛍光二重染色法を用いた調査2013

    • Author(s)
      田村賢志,影山陸,南谷靖史
    • Journal Title

      電気学会プラズマパルスパワー 放電合同研究会資料

      Volume: PPT13030 Pages: 1-5

    • NAID

      10031175161

    • Related Report
      2013 Annual Research Report
  • [Journal Article] バイオエレクトリクス応用のための共振伝送線路を用いたSOSダイオード方式クラスタバーストパルス発生装置の開発2013

    • Author(s)
      松窪大祐,南谷靖史
    • Journal Title

      電気学会パルスパワー研究会資料

      Volume: PPT13067 Pages: 5-9

    • NAID

      10031193617

    • Related Report
      2013 Annual Research Report
  • [Journal Article] Development of a Cluster Burst Pulse Generator Based on a SOS Diode Switch for Bioelectrics Applications2012

    • Author(s)
      Takashi Toyooka, Yasushi Minamitani
    • Journal Title

      Proceedings of the IEEE 2011 Pulsed Power Conference

      Volume: (CD-ROM)

    • Related Report
      2013 Final Research Report
  • [Journal Article] 非線形伝送線路を用いたがん治療用高周波バーストパルス発生装置の開発2012

    • Author(s)
      阿部優一,南谷靖史
    • Journal Title

      電気学会パルスパワー・放電合同研究会資料

      Volume: PPT-12-026~034, ED-12-052~062 Pages: 51-55

    • NAID

      10030604637

    • Related Report
      2012 Research-status Report
  • [Journal Article] がん治療のためのSOSダイオードを用いた高周波クラスタバーストパルス発生装置の開発2012

    • Author(s)
      松窪大祐,豊岡隆侍,南谷靖史
    • Journal Title

      電気学会パルスパワー・放電合同研究会資料

      Volume: PPT-12-026~034, ED-12-052~062 Pages: 45-49

    • NAID

      10030604630

    • Related Report
      2012 Research-status Report
  • [Journal Article] Development of a Cluster Burst Pulse Generator Based On a SOS Diode Switch for Bioelectrics Applications2012

    • Author(s)
      Takashi Toyooka, Yasushi Minamitani
    • Journal Title

      Proceedings of the IEEE 2011 Pulsed Power Conference

      Volume: CD-ROM

    • Related Report
      2011 Research-status Report
  • [Journal Article] 狭帯域高電界パルスに対する子宮頸がん細胞の生体応答解析2012

    • Author(s)
      諸富仁哉,矢野美沙子,光武和典,勝木 淳,秋山秀典,豊岡隆侍,品川和希,南谷靖史
    • Journal Title

      電気学会パルスパワー研究会資料

      Volume: PPT-12-001~015 Pages: 17-22

    • NAID

      10030329950

    • Related Report
      2011 Research-status Report
  • [Journal Article] SOSダイオードを用いた医療用クラスタバーストパルス発生装置の開発2011

    • Author(s)
      豊岡隆侍,南谷靖史
    • Journal Title

      電気学会パルスパワー・放電合同研究会資料

      Volume: PPT-11-001~024, ED-11-024~047

    • NAID

      10029075727

    • Related Report
      2011 Research-status Report
  • [Presentation] DEVELOPMENT OF A HIGH FREQUENCY CLUSTER BURST PULSE GENERATOR BASED ON A SOS DIODE USING TRANSMISSION LINE RESONANT FOR BIOELECTRICS APPLICATIONS2013

    • Author(s)
      Daisuke Matsukubo, Yasushi Minamitani
    • Organizer
      The 19th IEEE International Pulsed Power Conference
    • Place of Presentation
      Hyatt Regency San Francisco (アメリカ合衆国)
    • Related Report
      2013 Annual Research Report
  • [Presentation] Investigation of Frequency Response of Apoptosis Induction to Budding Yeast by Burst Pulse Electric Field for Cancer Treatment2013

    • Author(s)
      K. Tamura, R. Kageyama, Y. Minamitani
    • Organizer
      The 19th IEEE International Pulsed Power Conference
    • Place of Presentation
      Hyatt Regency San Francisco (アメリカ合衆国)
    • Related Report
      2013 Annual Research Report
  • [Presentation] パルス電界の周波数による細胞へのアポトーシス誘導状況の蛍光二重染色法を用いた調査2013

    • Author(s)
      田村賢志,影山陸,南谷靖史
    • Organizer
      電気学会プラズマパルスパワー 放電合同研究会
    • Place of Presentation
      まちなかキャンパス長岡
    • Related Report
      2013 Annual Research Report
  • [Presentation] バイオエレクトリクス応用のための共振伝送線路を用いたSOSダイオード方式クラスタバーストパルス発生装置の開発2013

    • Author(s)
      松窪大祐,南谷靖史
    • Organizer
      電気学会パルスパワー研究会
    • Place of Presentation
      計算科学センタービル
    • Related Report
      2013 Annual Research Report
  • [Presentation] The dependence of protein expression level in HeLa cells on the frequency of high frequency burst pulse high electric field2012

    • Author(s)
      Yasushi Minamitani, Yoshie Kuramochi, Takashi Toyooka, Kazuki Shinagawa, Kazunori Mitsutake, Misako Yano, Masaya, Morotomi, Sunao Katsuki, Hidenori Akiyama
    • Organizer
      2012 International Bioelectrics Symposium
    • Place of Presentation
      熊本市,KKRホテル熊本
    • Year and Date
      2012-09-07
    • Related Report
      2013 Final Research Report
  • [Presentation] Development of a High Frequency Cluster Burst Pulse Generator Based on a SOS Diode for Cancer Treatment2012

    • Author(s)
      Daisuke Matsukubo, Takashi Toyooka, Yasushi Minamitani
    • Organizer
      2012 International Bioelectrics Symposium
    • Place of Presentation
      熊本市,KKRホテル熊本
    • Year and Date
      2012-09-07
    • Related Report
      2013 Final Research Report
  • [Presentation] Development of a RF Burst Pulse Generator Using a Nonlinear Transmission Line for Cancer Treatment2012

    • Author(s)
      Yuichi Abe, Yasushi Minamitani
    • Organizer
      2012 International Bioelectrics Symposium
    • Place of Presentation
      熊本市,KKRホテル熊本
    • Year and Date
      2012-09-07
    • Related Report
      2013 Final Research Report
  • [Presentation] 非線形伝送線路を用いたがん治療用高周波バーストパルス発生装置の開発2012

    • Author(s)
      阿部優一,南谷靖史
    • Organizer
      電気学会パルスパワー・放電合同研究会
    • Place of Presentation
      米沢市,山形大学工学部
    • Related Report
      2012 Research-status Report
  • [Presentation] がん治療のためのSOSダイオードを用いた高周波クラスタバーストパルス発生装置の開発2012

    • Author(s)
      松窪大祐,豊岡隆侍,南谷靖史
    • Organizer
      電気学会パルスパワー・放電合同研究会
    • Place of Presentation
      米沢市,山形大学工学部
    • Related Report
      2012 Research-status Report
  • [Presentation] Development of a RF burst pulse generator using a non-linear transmission line for cancer treatment2012

    • Author(s)
      Yuichi Abe, Yasushi Minamitani
    • Organizer
      IEEE 2011 Power Modulator Conference
    • Place of Presentation
      Hilton San Diedo Bayfront, San Diego, CA, USA
    • Related Report
      2012 Research-status Report
  • [Presentation] Development of a RF Burst Pulse Generator Using a Nonlinear Transmission Line for Cancer Treatment2012

    • Author(s)
      Yuichi Abe, Yasushi Minamitani
    • Organizer
      2012 International Bioelectrics Symposium
    • Place of Presentation
      熊本市,KKRホテル熊本
    • Related Report
      2012 Research-status Report
  • [Presentation] Investigation of Effect into the Cell by High Frequency Component of Burst Pulse Electric Field Using a Budding Yeast for Cancer Treatment2012

    • Author(s)
      Kenji Tamura, Takashi Toyooka, Yoshie Kuramochi, Yasushi Minamitani
    • Organizer
      2012 International Bioelectrics Symposium
    • Place of Presentation
      熊本市,KKRホテル熊本
    • Related Report
      2012 Research-status Report
  • [Presentation] Development of a High Frequency Cluster Burst Pulse Generator Based on a SOS Diode for2012

    • Author(s)
      Daisuke Matsukubo, Takashi Toyooka, Yasushi Minamitani
    • Organizer
      2012 International Bioelectrics Symposium
    • Place of Presentation
      熊本市,KKRホテル熊本
    • Related Report
      2012 Research-status Report
  • [Presentation] The dependence of protein expression level in HeLa cells on the frequency of high frequency burst pulse high electric field2012

    • Author(s)
      Yasushi Minamitani, Yoshie Kuramochi, Takashi Toyooka, Kazuki Shinagawa, Kazunori Mitsutake, Misako Yano, Masaya Morotomi, Sunao Katsuki, Hidenori Akiyama
    • Organizer
      2012 International Bioelectrics Symposium
    • Place of Presentation
      熊本市,KKRホテル熊本
    • Related Report
      2012 Research-status Report
  • [Presentation] 狭帯域高電界パルスに対する子宮頸がん細胞の生体応答解析2012

    • Author(s)
      諸富仁哉,矢野美沙子,光武和典,勝木 淳,秋山秀典,豊岡隆侍,品川和希,南谷靖史
    • Organizer
      電気学会パルスパワー研究会
    • Place of Presentation
      熊本大学
    • Related Report
      2011 Research-status Report
  • [Presentation] 非線形伝送線路を用いた高周波バーストパルス発生装置の開発2012

    • Author(s)
      阿部優一,南谷靖史
    • Organizer
      平成23年度核融合科学研究所研究会「パルスパワー生成プラズマの物理と応用」
    • Place of Presentation
      核融合科学研究所
    • Related Report
      2011 Research-status Report
  • [Presentation] Development of a Cluster Burst Pulse Generator Based On a SOS Diode Switch for Bioelectrics Applications2011

    • Author(s)
      Takashi Toyooka, Yasushi Minamitani
    • Organizer
      IEEE 2011 Pulsed Power Conference
    • Place of Presentation
      Chicago, IL, USA
    • Related Report
      2011 Research-status Report
  • [Presentation] SOSダイオードを用いた医療用クラスタバーストパルス発生装置の開発2011

    • Author(s)
      豊岡隆侍,南谷靖史
    • Organizer
      電気学会パルスパワー・放電合同研究会
    • Place of Presentation
      岩手大学
    • Related Report
      2011 Research-status Report
  • [Presentation] 高強度パルス電界によるがん治療を目的とした電界周波数別の細胞へのアポトーシス誘導状況の調査

    • Author(s)
      影山陸,田村賢志,南谷靖史
    • Organizer
      日本生体医工学会東北支部大会
    • Place of Presentation
      山形大学医学部
    • Related Report
      2013 Annual Research Report

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Published: 2011-08-05   Modified: 2019-07-29  

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