Oscillator network modeling of the circadian rhythms and its application to their control
| Project/Area Number |
23560446
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Communication/Network engineering
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| Research Institution | Ritsumeikan University |
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Principal Investigator |
TOKUDA Isao 立命館大学, 理工学部, 教授 (00261389)
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| Co-Investigator(Kenkyū-buntansha) |
HONMA Sato 北海道大学, 医学研究科, 特任教授 (20142713)
FUKUDA Hirokazu 大阪府立大学, 工学研究科, 准教授 (90405358)
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| Project Period (FY) |
2011 – 2013
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| Project Status |
Completed (Fiscal Year 2013)
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| Budget Amount *help |
¥5,330,000 (Direct Cost: ¥4,100,000、Indirect Cost: ¥1,230,000)
Fiscal Year 2013: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2012: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2011: ¥2,860,000 (Direct Cost: ¥2,200,000、Indirect Cost: ¥660,000)
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| Keywords | 概日リズム / 非線形動力学 / 同期 / 制御 / 視交叉上核 / サーカディアンリズム / ネットワークダイナミクス / 自律振動 |
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| Research Abstract |
Towards understanding the role of Cry genes in the mammalian circadian clock, this project attempted to construct a mathematical model of a neuronal network in the suprachiasmatic nucleus (SCN). Single cell analysis was applied to the SCN data recorded from Cry1 and Cry2 double deficient mice. Compared to the wild-type SCN, the mutant SCN neurons showed larger level of noise and more variation of the periods. The SCN slice was further analyzed. The neonate showed a clear rhythmicity with synchronized neuronal activities, whereas this rhythmicity was instantly destroyed in the adult. Our mathematical model implies that the network structure (coupling strength and phase) may change during the development, which may drastically change the network dynamics.
Next, multiple light pulses were injected to Arabidopsis thaliana to desynchronize and resynchronize the plant circadian system. Our experiment demonstrates the efficiency of using the phase response property for controlling the plant.
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Report
(4 results)
Research Products
(64 results)
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[Journal Article] Production of biologically active human thioredoxin 1 protein in lettuce chloroplasts2011
Author(s)
S. Lim, H. Ashida, R. Watanabe, K. Inai, Y.-S. Kim, K. Mukougawa, H. Fukuda, K.-I. Tomizawa, K.-I. Ushiyama, H. Asao, M. Tamoi, H. Masutani, S. Shigeoka, J. Yodoi, A. Yokota
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Journal Title
Plant Mol. Biol.
Volume: Vol. 76
Issue: 3-5
Pages: 335-44
DOI
NAID
Related Report
Peer Reviewed
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[Journal Article] Mathematical Models and Numerical Schemes for the Simulation of Human Phonation2011
Author(s)
Fariborz Alipour, Christoph Bruecker, Douglas D. Cook, Andreas Goemel, Manfred Kaltenbacher, Willy Mattheus, Luc Mongeau, Eric Nauman, Ruediger Schwarze, Isao Tokuda, Stefan Zoerner
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Journal Title
Current Bioinformatics
Volume: Vol. 6, No. 3
Pages: 323-343
Related Report
Peer Reviewed
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