Detection of light absorption and scattering disorder caused by diseases in skin multi-layered structure

• Project/Area Number: 23560492
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Measurement engineering
• Research Institution: Muroran Institute of Technology
• Principal Investigator: AIZU YOSHIHISA 室蘭工業大学, 工学(系)研究科(研究院), 教授 (20212350)
• Co-Investigator(Kenkyū-buntansha): SHIMATANI Yuichi 東京都市大学, 工学部, 准教授 (20154263)
• Co-Investigator(Renkei-kenkyūsha): YUASA Tomonori 室蘭工業大学, 工学研究科, 准教授 (60241410)
• Project Period (FY): 2011 – 2013
• Project Status: Completed (Fiscal Year 2013)
• Budget Amount: ¥5,330,000 (Direct Cost: ¥4,100,000、Indirect Cost: ¥1,230,000); Fiscal Year 2013: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000); Fiscal Year 2012: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000); Fiscal Year 2011: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
• Keywords: 皮膚計測 / 分光反射率 / イメージング / ハイパースペクトル

Research Abstract

We studied to develop a novel and stable technique of detecting a skin lesion with a high spatial resolution based on a pixel level for reliable monitoring of serious skin diseases. We designed and developed a new imaging optical system with hyper-spectral technique for wavelength-selective acquisition of light absorption and scattering disorders caused by pigment and structual changes in skin. We also performed multi-layered Monte Carlo simulation and fitting of spectral reflectance using a multi-layered skin tissue model in a pixel unit. We finally confirmed the usefulness of this method in experiments.

Research Products

• [Journal Article] Improvement of estimation parameter for frame rate analysis of blood flow using laser speckle image sensing (2014)
  • Author(s): Naomichi Yokoi, Takaaki Maeda, Yuichi Shimatani, Hideki Funamizu, and Yoshihisa Aizu
  • Journal Title: Optics and Lasers in Engineering Volume: vol.52 Pages: 156-166
  • Peer Reviewed
• [Journal Article] Improvement of estimation parameter for frame-rate analysis of blood flow using laser speckle image sensing (2014)
  • Author(s): Naomichi Yokoi, Takaaki Maeda, Yuichi Shimatani, Hideki Funamizu, and Yoshihisa Aizu
  • Journal Title: Optics and Lasers in Engineering Volume: 52 Pages: 156-166
  • Peer Reviewed
• [Journal Article] Estimation of Melanin and Hemoglobin Using Spectral Reflectance Images Reconstructed from a Digital RGB Image by the Wiener Estimation Method (2013)
  • Author(s): Izumi Nishidate, Takaaki Maeda, Kyuichi Niizeki, and Yoshihisa Aizu
  • Journal Title: Sensors 2013 Volume: vol. 13 Pages: 7902-7915
  • NAID: 120005323273
  • Peer Reviewed
• [Journal Article] Visualization of peripheral vasodilative indices in human skin by use of red, green, blue images (2013)
  • Author(s): Izumi Nishidate, Noriyuki Tanaka, Tatsuya Kawase, Takaaki Maeda, Tomonori Yuasa, Yoshihisa Aizu, Tetsuya Yuasa, and Kyuichi Niizeki
  • Journal Title: Journal of Biomedical Optics Volume: vol.18,No. 6 Pages: 1-9
  • Peer Reviewed
• [Journal Article] Estimation of Melanin and Hemoglobin Using Spectral Reflectance Images Reconstructed from a Digital RGB Image by the Wiener Estimation Method (2013)
  • Author(s): Izumi Nishidate, Takaaki Maeda, Kyuichi Niizeki, and Yoshihisa Aizu
  • Journal Title: Sensors Volume: 13 Issue: 6 Pages: 7902-7915
  • DOI: 10.3390/s130607902
  • NAID: 120005323273
  • Peer Reviewed
• [Journal Article] 皮膚分光反射率のモンテカルロシミュレーションとその応用 (2012)
  • Author(s): 相津佳永
  • Journal Title: 色材協会誌 Volume: 85 Pages: 465-470
  • NAID: 10031128406
  • Peer Reviewed
• [Journal Article] Spectral reflectance fitting based on Monte Carlo simulation using a multi layered skin tissue model (2011)
  • Author(s): Yoshihisa Aizu, Takaaki Maeda, Tomohiro Kuwahara, and Tetsuji Hirao
  • Journal Title: Proceedings of SPIE-OSA Biomedical Optics, 'Diffuse Optical Imaging III', edited by Andreas H. Hielscher, Paola Taroni, SPIE Volume: vol.8088 Pages: 1-9
  • Peer Reviewed
• [Journal Article] Non invasive spectral imaging of skin chromophores based on multiple regression analysis aided by Monte Carlo simulation (2011)
  • Author(s): Izumi Nishidate, Aditya Wiswadarma, Yota Hase, Noriyuki Tanaka, Takaaki Maeda, Kyuichi Niizeki, and Yoshihisa Aizu
  • Journal Title: Optics Letter Volume: vol.36, no.16 Pages: 3239-3241
  • Peer Reviewed
• [Journal Article] Noninvasive imaging of human skin hemodynamics using a digital red green blue camera (2011)
  • Author(s): Izumi Nishidate, Noriyuki Tanaka, Tatsuya Kawase, Takaaki Maeda, Tomonori Yuasa, Yoshihisa Aizu, Tetsuya Yuasa, and Kyuichi Niizeki
  • Journal Title: Journal of Biomedical Optics Volume: vol.16, no.8 Pages: 1-14
  • Peer Reviewed
• [Journal Article] Spectral reflectance fitting based on Monte Carlo simulation using a multi-layered skin tissue model (2011)
  • Author(s): Yoshihisa Aizu
  • Journal Title: Proceedings of SPIE-OSA Biomedical Optics Volume: vol.8088
  • Peer Reviewed
• [Journal Article] 皮膚組織多層構造モデリングと光伝搬シミュレーション (2011)
  • Author(s): 相津佳永
  • Journal Title: 日本機械学会誌 Volume: Vol.114 Pages: 541-541
• [Presentation] ハイパースペクトルイメージングによる顔画像分光反射率の空間分布解析 (2013)
  • Author(s): 和野暢之,稲垣雄太,前田貴章,船水英希,相津佳永
  • Organizer: Optics & Photonics Japan 2013
  • Place of Presentation: 奈良市(12aA8)
• [Presentation] 多変量解析を用いた皮下内出血画像の色素濃度推定 (2013)
  • Author(s): 柴田一馬,古御堂剛,橘諒,船水英希,相津佳永
  • Organizer: 第60回応用物理学会春季学術講演会
  • Place of Presentation: 神奈川県厚木市(30a-PA2-6)
• [Presentation] 顔画像ハイパースペクトルイメージング用拡散照明装置の試作 (2013)
  • Author(s): 和野暢之,橘諒,船水英希,相津佳永
  • Organizer: 第60回応用物理学会春季学術講演会
  • Place of Presentation: 神奈川県厚木市(30a-PA2-5)
• [Presentation] Improvement of temporal resolution in blood concentration imaging using NIR speckle patterns (2013)
  • Author(s): Naomichi Yokoi, Yuichi Shimatani, Masaki Kyoso, Hideki Funamizu, Yoshihisa Aizu
  • Organizer: SPIE-OSA European Conferences on Biomedical Optics
  • Place of Presentation: International Congress Centre Munich, Munich, Germany
• [Presentation] Noncontact plethysmographic imaging based on diffuse reflectance spectroscopy using a digital RGB camera (2013)
  • Author(s): Izumi Nishidate, Ryohei Matsuda, Noriyuki Tanaka, Takaaki Maeda, Tomonori Yuasa, Tetsuya Yuasa, Kyuichi Niizeki, Yoshihisa Aizu
  • Organizer: SPIE-OSA European Conferences on Biomedical Optics
  • Place of Presentation: International Congress Centre Munich, Munich, Germany
• [Presentation] ハイパースペクトルイメージングによる顔画像分光反射率の空間分布解析 (2013)
  • Author(s): 和野暢之，稲垣雄太，前田貴章，船水英希，相津佳永
  • Organizer: 日本光学会学術講演会 Optics & Photonics Japan 2013
  • Place of Presentation: 奈良県新公会堂 奈良県，奈良市
• [Presentation] ハイパースペクトルイメージングと光伝搬モンテカルロ法を用いた皮膚分光反射率の空間分布解析 (2013)
  • Author(s): 船水英希，前田貴章，桑原智裕，相津佳永
  • Organizer: 第５２ 回 光波センシグ技術研究会
  • Place of Presentation: 東京理科大学神楽坂校舎森戸記念館 東京都，新宿区神楽坂
• [Presentation] 生体内光伝搬のシミュレーションとその応用 (2012)
  • Author(s): 相津佳永
  • Organizer: 第13回情報フォトニクス研究グループ研究会
  • Place of Presentation: 神奈川県三浦郡
  • Year and Date: 2012-09-28
  • Invited
• [Presentation] 光線追跡計算によるヒト皮膚モデルの反射率計測シミュレーション (2012)
  • Author(s): 松本旬,船水英希,西舘泉,相津佳永
  • Organizer: Optics & Photonics Japan 2012
  • Place of Presentation: 東京(25pA1)
• [Presentation] モンテカルロシミュレーションを用いた多層構造皮膚モデルにおける光伝搬解析 (2012)
  • Author(s): 古御堂剛,前田貴章,船水英希,相津佳永
  • Organizer: Optics & Photonics Japan 2012
  • Place of Presentation: 東京(25pA2)
• [Presentation] 多層構造皮膚モデルを用いた皮膚分光反射率の空間分布解析 (2012)
  • Author(s): 橘諒,桑原智裕,船水英希,前田貴章,相津佳永
  • Organizer: Optics & Photonics Japan 2012
  • Place of Presentation: 東京(25pA3)
• [Presentation] 多層構造皮膚モデルに基づく組織光侵達のモンテカルロ解析 (2012)
  • Author(s): 古御堂剛,秋吉騎慎,前田貴章,西舘泉,船水英希,相津佳永
  • Organizer: 第59回応用物理学関係連合講演会
  • Place of Presentation: 東京(17a-GP3-2)
• [Presentation] ヒト皮膚画像の分光反射率に基づく色素濃度分布解析 (2012)
  • Author(s): 橘諒,前田貴章,桑原智裕,船水英希,相津佳永
  • Organizer: 第59回応用物理学関係連合講演会
  • Place of Presentation: 東京(17a-GP3-3)
• [Presentation] 光伝搬モンテカルロ法を基礎としたヒト皮膚モデルにおける光線追跡計算 (2012)
  • Author(s): 松本旬,前田貴章,船水英希,相津佳永
  • Organizer: 第59回応用物理学関係連合講演会
  • Place of Presentation: 東京(17a-GP3-4)
• [Presentation] 多層構造モデルに基づく皮膚組織内光浸達のモンテカルロシミュレーション (2011)
  • Author(s): 秋吉騎慎
  • Organizer: 応用物理学会第４８回 光波センシング技術研究会講演会
  • Place of Presentation: 東京理科大学
• [Presentation] Application of spectroscopic sensing and imaging to dermatology and cosmetology
  • Author(s): Yoshihisa Aizu
  • Organizer: 10th Japan-Finland Joint Symposium on Optics in Engineering
  • Place of Presentation: 宇都宮大学 栃木県，宇都宮市
  • Invited
• [Presentation] Skin color generation and image reconstruction based on Monte Carlo simulation
  • Author(s): Yoshihisa Aizu, Takaaki Maeda, Hideki Funamizu, Tomohiro Kuwahara, and Tetsuji Hirao
  • Organizer: 日韓生体医用光学シンポジウム
  • Place of Presentation: Jeju island, Korea
  • Invited
• [Presentation] 生体内光伝搬のシミュレーションとその応用
  • Author(s): 相津佳永
  • Organizer: 第13回情報フォトニクス研究グループ研究会
  • Place of Presentation: 神奈川県三浦郡葉山，湘南国際村センター
  • Invited
• [Presentation] An aspect of biomedicalphotonics - Optical sensing and imaging techniques for dermatology and cosmetology
  • Author(s): Yoshihisa Aizu
  • Organizer: 第13回 千歳光科学国際フォーラム
  • Place of Presentation: 北海道千歳市，千歳科学技術大学
  • Invited