| Budget Amount *help |
¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000)
Fiscal Year 2013: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2012: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2011: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
|
|---|
| Research Abstract |
In this research, we have studied an anesthesia control system considering time variability of kinetics and effect of anesthetic drugs during surgery. First, we developed a pharmacokinetic model with a time-varying clearance, which represents time variability of hypnotic effect of propofol, an anesthetic drug. Utilizing the model, hypnosis can be kept properly by maintaining estimated effect-site concentration of propofol at a constant level. Second, we confirmed that Analgesia/Nociception Index is more effective as an analgesia index than existing indices, and constructed a hypnosis and analgesia control method considering interaction of propofol and remifentanil, an analgesic drug. Simulation results show that the developed control method can maintain hypnosis and analgesia appropriately if sufficient analgesia is achieved at the beginning of surgery.
|
