| Project/Area Number |
23560913
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Properties in chemical engineering process/Transfer operation/Unit operation
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| Research Institution | Fukuoka University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
SHIMURA Hideo 福岡大学, 医学部, 教授 (80178996)
IRIE Keiichi 福岡大学, 加齢脳科学研究所, ポストドクター (50509669)
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| Project Period (FY) |
2011 – 2013
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| Project Status |
Completed (Fiscal Year 2013)
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| Budget Amount *help |
¥5,330,000 (Direct Cost: ¥4,100,000、Indirect Cost: ¥1,230,000)
Fiscal Year 2013: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000)
Fiscal Year 2012: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2011: ¥2,730,000 (Direct Cost: ¥2,100,000、Indirect Cost: ¥630,000)
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| Keywords | バイオスカフォールド / 二酸化炭素 / 再生医療 / 超臨界流体 / 超音波 / 国際情報交換 / 再生医療材料 / バイオスキャホルド / 超臨界 |
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| Research Abstract |
We attempted to generate biologic scaffold materials composed of extracellular matrix (ECM) from animal tissues or organs by means of the supercritical fluid technology. In order to obtain the biologic scaffold materials which may overcome a severe shortage of donor organs for organ transplant, the separation of cellular components leading to allograft rejection and decellularization of whole organs, such as kidneys livers, hearts of rats and pigs was achieved by ultrasonic irradiation in liquid carbon dioxide at high pressure condition. The structural data of decellularized organs were obtained by a micro-focus X-ray CT. These structural data of decellularized organs may lead to multi production of biologic scaffold materials composed of extracellular matrix for donor organs for organ transplant in an industrial scale.
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