| Project/Area Number |
23560938
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Catalyst/Resource chemical process
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| Research Institution | Kumamoto Industrial Research Institute |
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Principal Investigator |
SHIROSAKI Tomohiro 熊本県産業技術センター(ものづくり室、材料・地域資源室、食品加工室), その他部局等, 研究主任 (70554054)
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| Co-Investigator(Kenkyū-buntansha) |
NAGAOKA Shoji 熊本県産業技術センター, 材料・地域資源室, 研究主幹 (10227994)
TAKAFUJI Makoto 熊本大学, 大学院自然科学研究科, 准教授 (50332086)
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| Co-Investigator(Renkei-kenkyūsha) |
IHARA Hirotaka 熊本大学, 大学院自然科学研究科, 教授 (10151648)
SAGAWA Takashi 京都大学, 大学院エネルギー科学研究科, 教授 (20225832)
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| Project Period (FY) |
2011 – 2013
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| Project Status |
Completed (Fiscal Year 2013)
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| Budget Amount *help |
¥5,460,000 (Direct Cost: ¥4,200,000、Indirect Cost: ¥1,260,000)
Fiscal Year 2013: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2012: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2011: ¥2,860,000 (Direct Cost: ¥2,200,000、Indirect Cost: ¥660,000)
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| Keywords | 太陽電池 / 太陽光発電 / 超分子化学 / 合成化学 / 再生可能エネルギー / リン脂質 / リポソーム / ジスルフィド結合 / 酸分解性 / エステル結合 / 有機薄膜太陽電池 / フラーレン / 放出制御 |
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| Research Abstract |
Although liposome has been studied as a career of drug and gene delivery, there are some problems in the release of inclusions of liposome. In order to release drugs in a cell, liposome should be destabilized in acid enviroments such as inside of endocytic vesicles. In this study, we synthesized the phospholipids with disulfide groups in alkyl chains, and prepared pH-sensitive liposome using disulfide groups containing phospholipids. The phospholipid was synthesized from sn-glycero-3-phosphocholine and disulfide group containing fatty acid in the presence of N,N'-diisopropylcarbodiimide and 4-dimethylaminopyridine. The pH-sensitive liposome was prepared at pH7.4, and pH dependent destabilization of the liposome was investigated. pH-sensitive liposome was casted on ITO electrode which was used for organic photovoltaic, and terated with acid. The morphology of the liposome was changed by the treatment of acid.
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