| Budget Amount *help |
¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2013: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000)
Fiscal Year 2012: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2011: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
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| Research Abstract |
We have (i) shown that amyloid beta (Ab) interacts with membranes in a species-dependent and membrane composition manner. They cause membrane transformation, breach and viscosity. These may contribute towards understanding toxicity mechanisms; (ii) studied how oxidation of cholesterol influences membrane dynamics, demonstrating that temperature increase renders oxidized membranes more fluid. We have similar findings using biological cells. The findings are useful for clarifying the impact of cholesterol in Ab-induced toxicity; (iv) oxidized membranes enhance Ab's association with membranes; (v) potential neuro-protective agents interact with membranes in a structure-dependent manner as does their ability to inhibit Ab aggregation. Unraveling the importance of these compounds, at a functional group level opens the key to tailored design of potential bioactive drug candidates. We have developed an immunosensor chip for Ab.
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