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Studies on the molecular mechanisms of gain-of-function in thraustochytrids

Research Project

Project/Area Number 23560945
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field Biofunction/Bioprocess
Research InstitutionHiroshima University

Principal Investigator

AKI Tsunehiro  広島大学, 先端物質科学研究科, 准教授 (80284165)

Project Period (FY) 2011 – 2013
Project Status Completed (Fiscal Year 2013)
Budget Amount *help
¥5,200,000 (Direct Cost: ¥4,000,000、Indirect Cost: ¥1,200,000)
Fiscal Year 2013: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000)
Fiscal Year 2012: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Fiscal Year 2011: ¥2,470,000 (Direct Cost: ¥1,900,000、Indirect Cost: ¥570,000)
Keywords発酵生産 / 脂質 / 不飽和脂肪酸 / カロテノイド / 炭化水素 / ラビリンチュラ / オーランチオキトリウム属 / ドコサヘキサエン酸 / アスタキサンチン / ラビリンチュラ類
Research Abstract

Thraustochytrids are marine eukaryotic microorganisms that are industrially promising due to their ability of value-added lipid production and are considered to gain the evolutionally characteristic function of such lipid biosynthesis. To evaluate the hypothesis and elucidate its molecular mechanism, factors involving the gene transfer and lipid biosynthesis were analyzed based on genome and transcriptome data. This revealed novel transposons and carotenoid synthase, which provided a model suitable for examining the gain of specific function.

Report

(4 results)
  • 2013 Annual Research Report   Final Research Report ( PDF )
  • 2012 Research-status Report
  • 2011 Research-status Report
  • Research Products

    (34 results)

All 2014 2013 2012 2011 Other

All Journal Article (7 results) (of which Peer Reviewed: 6 results) Presentation (24 results) (of which Invited: 7 results) Book (1 results) Remarks (2 results)

  • [Journal Article] Regulation of polyunsaturated fatty acid biosynthesis by seaweed fucoxanthin and its metabolite in cultured hepatocytes.2014

    • Author(s)
      Aki, T., Yamamoto, M., Takahashi, T., Tomita, K., Toyoura, Ri., Iwashita, K., Kawamoto, S., Hosokawa, M., Miyashita, K., Ono, K.
    • Journal Title

      Lipids

      Volume: 49 Issue: 2 Pages: 133-141

    • DOI

      10.1007/s11745-013-3856-5

    • Related Report
      2013 Annual Research Report 2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] Behavior of organics in kelp during hydrothermal pretreatment of kelp and effect of salt on it2014

    • Author(s)
      Matsumoto R., Aki T., Okamura Y., Tajima T., Nakashimada Y., Matsumura Y.
    • Journal Title

      J. Jpn. Inst. Energy

      Volume: (accepted)

    • Related Report
      2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] Modification in enzymatic protocol for regiospecific analysis of solid fat, and evaluation of acylmigration in regiospecific transesterification by CALB using structured lipid2014

    • Author(s)
      Watanabe Y., Sato S., Sera S., Sato C., Yoshinaga K., Nagai T., Sato R., Iwasaka H., Aki T.
    • Journal Title

      J. Am. Oil Chem. Soc.

      Volume: (accepted)

    • Related Report
      2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] Behavior of organics in kelp during hydrothermal pretreatment of kelp and effect of salt on it.2014

    • Author(s)
      Matsumoto R., Aki T., Okamura Y., Tajima T., Nakashimada Y., Matsumura Y.
    • Journal Title

      J. Jpn. Inst. Energy

      Volume: 未定

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Utilization of Waste Syrup for Production of Polyunsaturated Fatty Acids and Xanthophylls by <i>Aurantiochytrium</i>2013

    • Author(s)
      Iwasaka H., Aki T., Adachi H., Watanabe K., Kawamoto S., Ono K.
    • Journal Title

      Journal of Oleo Science

      Volume: 62 Issue: 9 Pages: 729-736

    • DOI

      10.5650/jos.62.729

    • NAID

      130004436092

    • ISSN
      1345-8957, 1347-3352
    • Related Report
      2013 Annual Research Report 2013 Final Research Report 2012 Research-status Report
    • Peer Reviewed
  • [Journal Article] The behavior of sugar in hydrothermal pretreatment of laminaria2013

    • Author(s)
      Matsumoto R., Aki T., Okamura Y., Tajima T., Nakashimada Y., Matsumura Y.
    • Journal Title

      21st European Biomass Conference and Exhibition

    • Related Report
      2013 Final Research Report
  • [Journal Article] Prophylactic effect of Lactobacillus oral vaccine expressing a Japanese cedar pollen allergen2012

    • Author(s)
      K.Ohkouchi, et al
    • Journal Title

      J.Biosci.Bioeng.

      Volume: 113 Issue: 4 Pages: 536-41

    • DOI

      10.1016/j.jbiosc.2011.11.025

    • Related Report
      2012 Research-status Report
    • Peer Reviewed
  • [Presentation] 海洋微生物を用いた高付加価値油脂の生産2013

    • Author(s)
      秋庸裕
    • Organizer
      「知的クラスター形成に向けた研究拠点構築事業」シンポジウム
    • Place of Presentation
      沖縄産業支援センター
    • Year and Date
      2013-12-19
    • Related Report
      2013 Final Research Report
  • [Presentation] Bioconversion of seaweed saccharides to value-added lipids2013

    • Author(s)
      Aki T., Arafiles K., Iwasaka H., Okamura Y., Matsumura Y., Nakashimada Y.
    • Organizer
      9th International Symposium on Biocatalysis and Agricultural Biotechnology
    • Place of Presentation
      Piestany, Slovak Republic
    • Year and Date
      2013-10-15
    • Related Report
      2013 Final Research Report
  • [Presentation] ラビリンチュラ類の分子育種による機能開発2013

    • Author(s)
      岩坂宏明, 佐藤亮太, Kim Arafiles, 秋庸裕
    • Organizer
      第15回マリンバイオテクノロジー学会大会シンポジウム「ラビリンチュラ類を用いたバイオテクノロジーの展望」
    • Place of Presentation
      沖縄県市町村自治会館
    • Year and Date
      2013-06-02
    • Related Report
      2013 Final Research Report
  • [Presentation] 有用微細藻類のゲノム解読とその応用2013

    • Author(s)
      岩坂宏明, 小柳亮, 秋庸裕
    • Organizer
      第15回マリンバイオテクノロジー学会大会シンポジウム「マリンゲノミクスその新たな躍動」
    • Place of Presentation
      沖縄県市町村自治会館
    • Year and Date
      2013-06-01
    • Related Report
      2013 Final Research Report
  • [Presentation] Production of high value-added lipids by marine thraustochytrids2013

    • Author(s)
      T. Aki
    • Organizer
      2nd International Symposium on Marine Biomass Utilization
    • Place of Presentation
      Hiroshima University
    • Year and Date
      2013-04-11
    • Related Report
      2013 Final Research Report
  • [Presentation] Oil production using microbes2013

    • Author(s)
      T. Aki
    • Organizer
      1st International Symposium on Marine Biomass Utilization
    • Place of Presentation
      Hiroshima University
    • Year and Date
      2013-01-28
    • Related Report
      2013 Final Research Report
  • [Presentation] ラビリンチュラにおける機能性脂質の生合成機構2013

    • Author(s)
      秋庸裕
    • Organizer
      第3回学際的脂質創生研究部会講演会
    • Place of Presentation
      京都大学
    • Year and Date
      2013-01-25
    • Related Report
      2013 Final Research Report
  • [Presentation] 海洋微生物による高付加価値油脂の生産2013

    • Author(s)
      秋庸裕
    • Organizer
      第6回中国地域バイオマス利用研究会シンポジウム/第10回広島大学バイオマスプロジェクト研究センター講演会「動き出した海洋バイオマス研究―CRESTプロジェクト」
    • Place of Presentation
      広島放送大学
    • Related Report
      2013 Final Research Report
  • [Presentation] 海洋微生物ラビリンチュラ類による機能性脂質の生産2012

    • Author(s)
      秋庸裕
    • Organizer
      第4回広島大学バイオマスイブニングセミナー
    • Place of Presentation
      広島大学
    • Year and Date
      2012-12-17
    • Related Report
      2013 Final Research Report
  • [Presentation] Improvement in enzymatic regiospecific analysis of TAG2012

    • Author(s)
      Y. Watanabe, S. Sato, S. Sera, C. Sato, T. Nagai, R. Sato, and T. Aki
    • Organizer
      8th International Symposium on Biocatalysis and Agricultural Biotechnology
    • Place of Presentation
      California, USA
    • Year and Date
      2012-10-28
    • Related Report
      2013 Final Research Report
  • [Presentation] 海洋微生物ラビリンチュラにおける機能性脂質の生合成とその利用2012

    • Author(s)
      秋庸裕
    • Organizer
      第5回オレオライフサイエンス部会セミナー「海洋性生物と機能性脂質-その新しい展開」
    • Place of Presentation
      東京海洋大学
    • Year and Date
      2012-06-19
    • Related Report
      2013 Final Research Report
  • [Presentation] Biosynthesis and function of polyunsaturated fatty acids in thraustochytrid2012

    • Author(s)
      T. Aki, H. Iwasaka, H. Adachi, S. Kawamoto, K. Ono
    • Organizer
      103rd American Oil Chemists' Society Annual Meeting & Expo
    • Place of Presentation
      Long Beach, CA, USA
    • Year and Date
      2012-05-01
    • Related Report
      2013 Final Research Report 2012 Research-status Report
  • [Presentation] 微生物による機能性脂肪酸生産のための遺伝子利用技術2012

    • Author(s)
      秋庸裕
    • Organizer
      日本水産学会春季大会シンポジウム「水産物由来健康機能成分の機能解析と利用技術開発-有効利用と次なる展開-」
    • Place of Presentation
      東京海洋大学
    • Year and Date
      2012-03-26
    • Related Report
      2013 Final Research Report
  • [Presentation] Analysis, modification, and utilization of functional lipids from thraustochytrids2011

    • Author(s)
      T. Aki
    • Organizer
      Workshop in Vietnam National University
    • Place of Presentation
      Hanoi, Vietnam
    • Year and Date
      2011-12-16
    • Related Report
      2013 Final Research Report
  • [Presentation] ラビリンチュラ類(オーランチオキトリウム属)による高機能性油脂の生産2011

    • Author(s)
      秋庸裕
    • Organizer
      知的クラスター形成に向けた研究拠点構築事業・沖縄バイオサイエンスセミナー
    • Place of Presentation
      沖縄県工業技術センター
    • Year and Date
      2011-11-11
    • Related Report
      2013 Final Research Report
  • [Presentation] Analysis and modification of polyunsaturated fatty acid biosynthesis in thraustochytrid2011

    • Author(s)
      T. Aki, H. Iwasaka, H. Adachi, S. Kawamoto, K. Ono
    • Organizer
      7th International Symposium on Biocatalysis and Agricultural Biotechnology
    • Place of Presentation
      Kyoto
    • Year and Date
      2011-10-11
    • Related Report
      2013 Final Research Report
  • [Presentation] Biosynthesis and utilization of polyunsaturated fatty acids in thraustochytrid2011

    • Author(s)
      T. Aki, H. Iwasaka, H. Adachi, S. Kawamoto, K. Ono
    • Organizer
      International Union of Microbiological Societies 2011 Congress, symposium "Frontiers of marine thraustochytrid biotechnology"
    • Place of Presentation
      as convener; Sapporo
    • Year and Date
      2011-09-07
    • Related Report
      2013 Final Research Report
  • [Presentation] Bioconversion of seaweed saccharides to value-added lipids.

    • Author(s)
      Aki T., Arafiles K., Iwasaka H., Okamura Y., Matsumura Y., Nakashimada Y.
    • Organizer
      9th International Symposium on Biocatalysis and Agricultural Biotechnology
    • Place of Presentation
      Piestany, Slovak Republic
    • Related Report
      2013 Annual Research Report
    • Invited
  • [Presentation] Production of high value-added lipids by marine thraustochytrids.

    • Author(s)
      T. Aki
    • Organizer
      2nd International Symposium on Marine Biomass Utilization
    • Place of Presentation
      Hiroshima University
    • Related Report
      2013 Annual Research Report
    • Invited
  • [Presentation] 有用微細藻類のゲノム解読とその応用

    • Author(s)
      岩坂宏明、小柳 亮、秋 庸裕
    • Organizer
      第15回マリンバイオテクノロジー学会大会シンポジウム
    • Place of Presentation
      沖縄県市町村自治会館
    • Related Report
      2013 Annual Research Report
    • Invited
  • [Presentation] ラビリンチュラ類の分子育種による機能開発

    • Author(s)
      岩坂宏明、佐藤亮太、Kim Arafiles、秋 庸裕
    • Organizer
      第15回マリンバイオテクノロジー学会大会シンポジウム
    • Place of Presentation
      沖縄県市町村自治会館
    • Related Report
      2013 Annual Research Report
    • Invited
  • [Presentation] 海洋微生物を用いた高付加価値油脂の生産

    • Author(s)
      秋 庸裕
    • Organizer
      「知的クラスター形成に向けた研究拠点構築事業」シンポジウム
    • Place of Presentation
      沖縄産業支援センター
    • Related Report
      2013 Annual Research Report
    • Invited
  • [Presentation] Improvement in enzymatic regiospecific analysis of TAG

    • Author(s)
      Y. Watanabe, S. Sato, S. Sera, C. Sato, T. Nagai, R. Sato, T. Aki
    • Organizer
      8th International Symposium on Biocatalysis and Agricultural Biotechnology
    • Place of Presentation
      California, USA
    • Related Report
      2012 Research-status Report
    • Invited
  • [Presentation] Oil production using microbes

    • Author(s)
      T. Aki
    • Organizer
      International Symposium on Marine Biomass Utilization
    • Place of Presentation
      Higashi-Hiroshima, Japan
    • Related Report
      2012 Research-status Report
    • Invited
  • [Book] 石油業界からみたバイオマスエネルギー, 微細藻類によるエネルギー生産と事業展望2012

    • Author(s)
      冷牟田修一, 須田彰一郎, 秋庸裕, 竹山春子監修
    • Publisher
      シーエムシー出版
    • Related Report
      2013 Final Research Report
  • [Remarks] ホームページ

    • URL

      http://home.hiroshima-u.ac.jp/aki/

    • Related Report
      2013 Final Research Report
  • [Remarks] 秋研web@広大先端研

    • URL

      http://home.hiroshima-u.ac.jp/aki/

    • Related Report
      2012 Research-status Report

URL: 

Published: 2011-08-05   Modified: 2019-07-29  

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