| Budget Amount *help |
¥5,330,000 (Direct Cost: ¥4,100,000、Indirect Cost: ¥1,230,000)
Fiscal Year 2013: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2012: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2011: ¥2,470,000 (Direct Cost: ¥1,900,000、Indirect Cost: ¥570,000)
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| Research Abstract |
Intrinsic or acuired multidrug resistance (MDR) of cancer cells is one of the major obstacles in the chemotherapeutic treatment of solid tumors. We have investigated three-dimensional cultures for the maintenance of various biological characteristics of normal hepatic cells.
In this research, we have succeeded in the expression of drug resistance phenomena of hepatic cancer cells and the development of the new assay system for screening of anticancer drugs using 96 well three-dimensional culture plate. Furthermore, we found that hybrid liposomes composed of dimyristoylphophatidylcnoline and polyoxyethylene dodecyl ether have remarkable inhibitory effect on the drug efflux activity of hepatic cancer cells which cultured in three-dimensionally. Consequently, hybrid liposomes will be a new anticancer drug to overcome the multidrug resistance of hepatic cancer cells.
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