Regulation of homeostasis by absorption and excretion in the digestive tract

• Project/Area Number: 23570006
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Genetics/Genome dynamics
• Research Institution: Okayama University
• Principal Investigator: NAKAGOSHI Hideki 岡山大学, 自然科学研究科, 准教授 (50314662)
• Research Collaborator: KIFUKU Naoto 岡山大学, 大学院自然科学研究科, 大学院生
• Project Period (FY): 2011 – 2013
• Project Status: Completed (Fiscal Year 2013)
• Budget Amount: ¥5,330,000 (Direct Cost: ¥4,100,000、Indirect Cost: ¥1,230,000); Fiscal Year 2013: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000); Fiscal Year 2012: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000); Fiscal Year 2011: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
• Keywords: ショウジョウバエ / マルピーギ管 / ストレス応答 / 排泄 / プロトンポンプ / セプテートジャンクション

Research Abstract

Malpighian tubules of Drosophila melanogaster have functions homologous to those of mammalian kidney, and maintain homeostasis by excreting waste matter from the body fluid. This study has shown that the homeodomain transcription factor Defective proventriculus (Dve) is essential for functional differentiation of these cells and their stress response to high-salt diet.

Research Products

• [Journal Article] The homeodomain protein defective proventriculus is essential for male accessory gland development to enhance fecundity in Drosophila. (2012)
  • Author(s): Minami, R.
  • Journal Title: PLoS One Volume: 7 Issue: 3 Pages: e32302-e32302
  • DOI: 10.1371/journal.pone.0032302
  • Peer Reviewed
• [Journal Article] Defective proventriculus specifies the ocellar region in the Drosophila head (2011)
  • Author(s): Takeshi Yorimitsu, Naruto Kiritooshi, Hideki Nakagoshi
  • Journal Title: Dev. Biol. Volume: 356 Issue: 2 Pages: 598-607
  • DOI: 10.1016/j.ydbio.2011.06.015
  • Peer Reviewed
• [Journal Article] Spatial and temporal requirement of Defective proventriculus activity during Drosophila midgut development (2011)
  • Author(s): Yoshiki Nakagawa, Shinobu Fujiwara-Fukuta, Takeshi Yorimitsu, Suzuka Tanaka, Ryunosuke Minami, Lily Shimooka, Hideki Nakagoshi
  • Journal Title: Mech. Dev. Volume: 128 Issue: 5-6 Pages: 258-267
  • DOI: 10.1016/j.mod.2011.02.003
  • Peer Reviewed
• [Journal Article] Pranidhi Sood, Nina Vogt, Rudy Behnia, Daniel Vasiliauskas, Elizabeth McDonald, Baotong Xie, Sebastian Koenig, Reinhard Wolf, Tiffany Cook, Brian Gebelein, Edo Kussell, Hideki Nakagoshi* and Claude Desplan* (* corresponding authors) Interlocked feedforward loops control cell-type-specic Rhodopsin expression in the Drosophila eye (2011)
  • Author(s): Robert J. Johnston Jr., Yoshiaki Otake
  • Journal Title: Cell Volume: 145 Issue: 6 Pages: 956-968
  • DOI: 10.1016/j.cell.2011.05.003
  • Peer Reviewed
• [Presentation] ショウジョウバエ中腸細胞の機能分化制御 (2014)
  • Author(s): 中越英樹
  • Organizer: 第58回日本応用動物昆虫学会大会
  • Place of Presentation: 高知
  • Year and Date: 2014-03-28
  • Invited
• [Presentation] ショウジョウバエ熱ショックタンパク質HSPsによる幼虫中腸機能の制御 (2014)
  • Author(s): 廣瀬篤, 高橋一男, 中越英樹
  • Organizer: 中国四国地区生物系三学会合同大会
  • Place of Presentation: 岡山
• [Presentation] ショウジョウバエ中腸細胞の機能分化制御 (2014)
  • Author(s): 中越英樹
  • Organizer: 第 58 回 日本応用動物昆虫学会大会
  • Place of Presentation: 高知市
  • Invited
• [Presentation] ショウジョウバエ熱ショックタンパク質 HSPs による幼虫中腸機能の制御 (2014)
  • Author(s): 廣瀬篤，高橋一男，中越英樹
  • Organizer: 中国四国地区生物系三学会合同大会
  • Place of Presentation: 岡山市
• [Presentation] Functional analysis of the transcription factor Dve in Drosophila malpighian tubules (2013)
  • Author(s): Naoto Kifuku and Hideki Nakagoshi
  • Organizer: The 2nd Asia-Pacific Drosophila Research Conference
  • Place of Presentation: Seoul, Korea
• [Presentation] 機能分化に関わる転写因子 Dve のドメイン解析 (2013)
  • Author(s): 北條聖奈，矢田和貴，中越英樹，渡辺直子
  • Organizer: 日本動物学会第84回大会
  • Place of Presentation: 岡山市
• [Presentation] ショウジョウバエマルピーギ管における転写制御因子Dveの機能解析 (2012)
  • Author(s): 来福七央人, 中越英樹
  • Organizer: 日本分子生物学会第35回年会
  • Place of Presentation: 博多
• [Presentation] ショウジョウバエマルピーギ管における転写制御因子 Dve の機能解析 (2012)
  • Author(s): 来福七央人，中越英樹
  • Organizer: 日本分子生物学会第35回年会
  • Place of Presentation: 福岡県博多市
• [Presentation] Intercellular communication through septate junctions is required to establish midgut functions in Drosophila (2011)
  • Author(s): 田中鈴香, 下岡リリー, 中越英樹
  • Organizer: 日本分子生物学会第34回年会
  • Place of Presentation: 横浜
  • Year and Date: 2011-12-13
• [Remarks]
  • URL: http://www.biol.okayama-u.ac.jp/nakagoshi/Kinou.html
• [Remarks]
  • URL: http://www.biol.okayama-u.ac.jp/nakagoshi/Kinou.html