The molecular and neuronal mechanisms for the germline-mediated regulation of the chemotactic behavior

• Project/Area Number: 23570007
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Genetics/Genome dynamics
• Research Institution: Kyushu University
• Principal Investigator: FUJIWARA Manabi 九州大学, 理学(系)研究科(研究院), 助教 (70359933)
• Project Period (FY): 2011 – 2013
• Project Status: Completed (Fiscal Year 2013)
• Budget Amount: ¥5,330,000 (Direct Cost: ¥4,100,000、Indirect Cost: ¥1,230,000); Fiscal Year 2013: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000); Fiscal Year 2012: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000); Fiscal Year 2011: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
• Keywords: 行動遺伝 / 行動 / 線虫 / 生殖腺 / 摂食 / 神経系 / 分子遺伝学 / C. elegans

Research Abstract

The molecular and neuronal mechanisms for the germline-mediated regulation of the chemotactic behaviorAnimals adequately change their behavioral patterns according to their developmental stage. We found that C. elegans larvae show a different preference in odorant from the adult. We also found that the germline loss makes adult animals show the larva-like odorant preference. These results implicate that some signals may be released from germline cells, which proliferate through the larval stages and the adult. By mutant analyses and a genome-wide RNAi screening, the energy state of the animal during larval stages is shown to be important for the germline-mediated regulation of chemotaxis.

Research Products

• [Journal Article] Forgetting in C. elegans is accelerated by neuronal communication via the TIR-1/JNK-1 pathway. (2013)
  • Author(s): Inoue A, Sawatari E, Hisamoto N, Kitazono T, Teramoto T, Fujiwara M, Matsumoto K, Ishihara T.
  • Journal Title: Cell Reports Volume: 3(3) Issue: 3 Pages: 808-819
  • DOI: 10.1016/j.celrep.2013.02.019
  • Peer Reviewed
• [Journal Article] Behavioral Choice between Conflicting Alternatives Is Regulated by a Receptor Guanylyl Cyclase, GCY-28, and a Receptor Tyrosine Kinase, SCD-2, in AIA Interneurons of Caenorhabditis elegans (2011)
  • Author(s): Shinkai, Y., Yamamoto, Y., Fujiwara, M., Tabata, T., Murayama, T., Hirotsu, T., Ikeda, D.D., Tsunozaki, M., Iino, Y., Bargmann, C.I., et al.
  • Journal Title: J Neurosci Volume: 31 Issue: 8 Pages: 3007-3015
  • DOI: 10.1523/jneurosci.4691-10.2011
  • Peer Reviewed
• [Journal Article] An expanded palette of genetically encoded Ca2+ indicators (2011)
  • Author(s): Zhao YG, Araki S, Wu JH, Teramoto T, Chang YF, Nakano M, Abdelfattah AS, Fujiwara M, Ishihara T, Nagai T, Campbell R
  • Journal Title: Science Volume: 333 Issue: 6051 Pages: 1888-1891
  • DOI: 10.1126/science.1208592
  • Peer Reviewed
• [Presentation] 線虫の感覚行動のライフサイクルにおける変化 (2013)
  • Author(s): 藤原学
  • Organizer: 第36回日本分子生物学会
  • Place of Presentation: 神戸
• [Presentation] 線虫の感覚行動のライフサイクルにおける変化 (2013)
  • Author(s): 藤原 学、佐藤 則子、丸山 新一、石原 健
  • Organizer: 第３６回日本分子生物学会
  • Place of Presentation: 神戸ポートアイランド
• [Presentation] 線虫の成長に伴う行動変化に関わるミトコンドリアの働き (2012)
  • Author(s): 藤原学
  • Organizer: 第35回日本分子生物学会年会
  • Place of Presentation: 福岡
• [Presentation] 生殖細胞が制御する線虫の感覚行動日本遺伝学会 (2012)
  • Author(s): 藤原学
  • Organizer: 84回大会
  • Place of Presentation: 九州大学
• [Presentation] Chemotaxis behavior is regulated by germline in C. elegans (2012)
  • Author(s): M. Fujiwara
  • Organizer: 2012 EMBO conference series : C. elegans Neurobiology
  • Place of Presentation: Heidelberg
• [Presentation] Chemotaxis behavior is regulated by germline in C. elegans. (2012)
  • Author(s): Manabi Fujiwara, Noriko Sato, Shinichi Maruyama, Takeshi Ishihara
  • Organizer: 2012 EMBO conference series: C. elegans Neurobiology
  • Place of Presentation: Heidelberg (ドイツ）
• [Presentation] 生殖細胞が制御する線虫の感覚行動 (2012)
  • Author(s): 藤原学、佐藤則子、石原健
  • Organizer: 日本遺伝学会
  • Place of Presentation: 福岡
  • Invited
• [Presentation] 線虫の成長に伴う行動変化に関わるミトコンドリアの働き (2012)
  • Author(s): 藤原学
  • Organizer: 日本分子生物学会年会
  • Place of Presentation: 福岡
  • Invited
• [Presentation] Chemotaxis behavior is regulated by germline in C. elegans (2011)
  • Author(s): M. Fujiwara
  • Organizer: 18^<th> International C. elegans meeting University of California
  • Place of Presentation: Los Angeles
• [Presentation] Chemotaxis behavior is regulated by germline in C. elegans. (2011)
  • Author(s): M. Fujiwara*, N. Sato, S. Maruyama, T. Akamine, T. Ishihara
  • Organizer: 18th International C. elegans meeting
  • Place of Presentation: Los Angeles
• [Remarks]
  • URL: http://www.biology.kyushu-u.ac.jp/~bunsiide/