The regulation of mitochondrial nucleoid division by a mitochondrial RCC1-like protein
Project/Area Number |
23570076
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Research Category |
Grant-in-Aid for Scientific Research (C)
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Allocation Type | Multi-year Fund |
Section | 一般 |
Research Field |
Morphology/Structure
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Research Institution | Nagoya University |
Principal Investigator |
SASAKI NARIE 名古屋大学, 理学(系)研究科(研究院), 准教授 (20359699)
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Project Period (FY) |
2011 – 2013
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Project Status |
Completed (Fiscal Year 2013)
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Budget Amount *help |
¥5,460,000 (Direct Cost: ¥4,200,000、Indirect Cost: ¥1,260,000)
Fiscal Year 2013: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2012: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2011: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
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Keywords | ミトコンドリア核様体 / 分裂 / RCC1様タンパク質 / RCC1様タンパク質 / 核様体分裂 |
Research Abstract |
Mitochondrial DNA (mt-DNA) is packed into a highly organized DNA-protein complex called the mitochondrial nucleoid (mt-nucleoid). Division of mt-nucleoid is necessary for mt-DNA distribution into daughter mitochondria. However, little is understood about the molecular mechanisms that regulate the mt-nucleoid division. In this study, we showed that a mitochondrial RCC1(Regulator of chromosome condensation 1)-like protein of P. polycephalum was involved in the mt-nucleoid division by controlling of the association of mt-nucleoids and cristae. We also identified a human mitochondrial RCC1-like protein (hmtRCC1). The down regulation analysis of hmtRCC1 showed that this protein might be involved in the mt-nucleoid division.
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Report
(4 results)
Research Products
(30 results)
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[Journal Article] DNA Packaging Proteins Glom and Glom2 Coordinately Organize the Mitochondrial Nucleoid of Physarum polycephalum2011
Author(s)
Itoh, K., Izumi, A., Mori, T., Dohmae, N., Yui, R., Maeda-Sano, K., Shirai, Y., Kanaoka, M.M., Kuroiwa, T., Higashiyama, T., Sugita, M., Murakami-Murofushi, K., Kawano, S., Sasaki, N.
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Journal Title
Mitochondria
Volume: 11
Issue: 4
Pages: 575-586
DOI
Related Report
Peer Reviewed
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[Journal Article] DNA packaging Glom and Glom2 coordinately organize the mitochondrial nucleoid of Physarum polycephalum.2011
Author(s)
Itoh, K., Izumi, A., Mori, T., Domae, N., Yui, R., Maeda-Sano, K., Shirai, Y., Kanaoka, M.M., Kuroiwa, T., Higashiyama, T., Sugita, M., Murakami-Murofushi, K., Kawano, S., Sasaki, N.
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Journal Title
Mitochondrion
Volume: 11
Pages: 575-586
Related Report
Peer Reviewed
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[Journal Article] Novel sterol glucosylttransferase in the animal tissue and cultured cells: evidence that glucosylceramide as glucose donor.2011
Author(s)
Akiyama, H., Sasaki, N., Hanazawa, S., Gotoh, M., Kobayashi, S., Murakami-Murofishi, K.
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Journal Title
Biochim. Biophys. Acta.
Volume: 1811
Pages: 314-322
Related Report
Peer Reviewed
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[Journal Article] Live-cell imaging reveals the dynamics of two sperm cells during double fertilization in Arabidopsis thaliana.2011
Author(s)
Hamamura, Y., Saito, C., Awai, C., Kurihara, D., miyawaki, A., Nakagawa, T., Kanaoka, M., M., Sasaki, N., Nakano, A., Berger, F., Higashiyama, T.
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Journal Title
Curr. Biol.
Volume: 21
Pages: 497-502
Related Report
Peer Reviewed
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[Journal Article] Chemical visualization of an attractant peptide,LURE2010
Author(s)
Goto, H., Okuda, S., Mizukami, A., Mori, H., Sasaki, N., Kurihara, D., Higashiyama, T.
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Journal Title
Plant Cell Physiol.
Volume: 52
Issue: 1
Pages: 49-58
DOI
NAID
Related Report
Peer Reviewed
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