Morphological analysis of synapse underlying pheromonal memory
| Project/Area Number |
23570084
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Morphology/Structure
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| Research Institution | Tokyo Metropolitan Institute of Medical Science |
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Principal Investigator |
ICHIKAWA Masumi 公益財団法人東京都医学総合研究所, 基盤技術研究センター, 副参事研究員 (20124414)
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| Co-Investigator(Renkei-kenkyūsha) |
MORIYA Keiko 公益財団法人東京都医学総合研究所, 認知症・高次脳機能研究分野, 研究員 (70392371)
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| Project Period (FY) |
2011 – 2013
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| Project Status |
Completed (Fiscal Year 2013)
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| Budget Amount *help |
¥5,460,000 (Direct Cost: ¥4,200,000、Indirect Cost: ¥1,260,000)
Fiscal Year 2013: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2012: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2011: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
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| Keywords | 副嗅球 / ニューロン / 鋤鼻系 / 電子顕微鏡 / シナプス可塑性 / フェロモン / マウス / 可塑性 |
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| Research Abstract |
Pregnancy in female mice is maintained by formation of pheromonal memory of partner male. The reciprocal synapse in the accessory olfactory bulb has been shown to play important role in this memory formation. The morphological change of this synapse is examined electron microscopically using transgenic mice in which the neuron is marked activity-dependently by GFP expression.
The size of synapse in these female mice was examined after mating. The size in GFP positive neuron was larger than those in GFP negative neuron. This result indicates that the morphological change of synapse take place in association with memory formation of pheromone. This study is expected to useful not only for research in olfaction but also for those generally in learning and memory.
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Report
(4 results)
Research Products
(15 results)
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[Journal Article] Tissue plasminogen activator (tPA) deficiency promotes early phase regeneration in the olfactory epithelium after bulbectomy2013
Author(s)
Makino N, Madoiwa S, Ohmori T, Katoh K, Ookawara S, Kanazawa T, Matsuo O, Ichikawa M, Mimuro J, Ichimura K, Sakata Y
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Journal Title
International Forum of Allergy & Rhinology
Volume: 3
Issue: 6
Pages: 458-467
DOI
Related Report
Peer Reviewed
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[Journal Article] Morphological assessment of the luminal surface of olfactory epithelium in mice deficient in tissue plasminogen activator following bulbectomy2012
Author(s)
Makino N, Ookawara S, Madoiwa S, Ohta Y, Ishikawa T, Katoh K, Takigami S, Kanazawa T, Matsuo O, Ichikawa M, Mimuro J, Sakata Y, Ichimura K
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Journal Title
J Laryngology Otology
Volume: 126
Pages: 1114-1120
Related Report
Peer Reviewed
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