The role of androgen signaling for hemato-vascular development
| Project/Area Number |
23570085
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Morphology/Structure
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| Research Institution | Okazaki Research Facilities, National Institutes of Natural Sciences |
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Principal Investigator |
OGINO Yukiko 大学共同利用機関法人自然科学研究機構(岡崎共通研究施設), 岡崎統合バイオサイエンスセンター, 助教 (00404343)
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| Co-Investigator(Renkei-kenkyūsha) |
YAMADA Gen 和歌山医科大学, 遺伝子制御学研究部, 教授 (80174712)
SAKAMOTO Hiroshi 熊本大学, 発生医学研究所, 助教 (00347014)
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| Project Period (FY) |
2011 – 2013
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| Project Status |
Completed (Fiscal Year 2013)
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| Budget Amount *help |
¥5,460,000 (Direct Cost: ¥4,200,000、Indirect Cost: ¥1,260,000)
Fiscal Year 2013: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2012: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
Fiscal Year 2011: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
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| Keywords | アンドロゲン / 内分泌 / 脊椎動物 / 発生 / 性ホルモン / 比較内分泌学 / 発生・分化 / 細胞・組織 / シグナル伝達 |
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| Research Abstract |
Androgen-androgen receptor (AR) signaling was found to be involved in the hemato-vascular development during the early embryogenesis of medaka. Using the combination of gene expression and cell lineage analyzes, we demonstrated that the differentiation of hemato-vascular progenitor cells from the lateral plate mesoderm is under the influence of androgen action. Androgen response was detected in erythroid cells and endothelial cells of yolk vein. We identified the Wnt and Bmp signaling genes as potential effector genes of androgen signaling. This study for the first time defines role of androgen-AR signaling during the early embryogenesis in medaka.
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Report
(4 results)
Research Products
(24 results)
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[Journal Article] Establishment of transactivation assay systems using fish, amphibian, reptilian and human thyroid hormone receptors2013
Author(s)
Oka, T., Mitsui-Watanabe, N., Tatarazako, N., Onishi, Y., Katsu, Y., Miyagawa, S., Ogino, Y., Yatsu, R., Kohno, S., Takase, M., Kawashima, Y., Aoki, Y., Guillette, L.J.Jr. and Iguchi, T.
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Journal Title
J. Appl. Toxicol
Volume: 33
Issue: 9
Pages: 991-1000
DOI
Related Report
Peer Reviewed
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[Journal Article] β-Catenin signaling regulates Foxa2 expression during endometrial hyperplasia formation2013
Author(s)
Villacorte M, Suzuki K, Hirasawa A, Ohkawa Y, Suyama M, Maruyama T, Aoki D, Ogino Y, Miyagawa S, Terabayashi T, Tomooka Y, Nakagata N, Yamada G
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Journal Title
Oncogene
Volume: 32
Issue: 29
Pages: 3477-3482
DOI
Related Report
Peer Reviewed
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[Journal Article] Gene expression profiles in the testis associated with testis-ova in adult Japanese medaka exposed to 17-ethinylestradiol2012
Author(s)
Hirakawa, I., Miyagawa, S., Katsu, Y., Kagami, Y., Tatarazako, N., Kobayashi, T., Kusano, T., Mizutani, T., Ogino, T., Ohta, Y., Iguchi, T.
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Journal Title
Chemosphere
Volume: 87
Issue: 7
Pages: 668-674
DOI
Related Report
Peer Reviewed
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[Journal Article] Comparative responsiveness to natural and synthetic estrogens of fish species commonly used in the laboratory and field monitoring2012
Author(s)
Lange A, Katsu Y, Miyagawa S, Ogino Y, Urushitani H, Kobayashi T, Hirai T, Shears JA, Nagae M, Yamamoto J, Ohnishi Y, Oka T, Tatarazako N, Ohta Y, Tyler CR, Iguchi T
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Journal Title
Aquatic Toxicology
Volume: 109
Pages: 250-258
DOI
Related Report
Peer Reviewed
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