The roles of immediate early genes and the morphological changes of dendritic spines in the filial imprinting of precocial birds.

• Project/Area Number: 23570098
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Animal physiology/Animal behavior
• Research Institution: Teikyo University
• Principal Investigator: HOMMA Koichi 帝京大学, 薬学部, 教授 (90251438)
• Co-Investigator(Renkei-kenkyūsha): AOKI Naoya 帝京大学, 薬学部, 助教 (50525334)
• Project Period (FY): 2011 – 2013
• Project Status: Completed (Fiscal Year 2013)
• Budget Amount: ¥5,330,000 (Direct Cost: ¥4,100,000、Indirect Cost: ¥1,230,000); Fiscal Year 2013: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000); Fiscal Year 2012: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000); Fiscal Year 2011: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
• Keywords: 学習臨界期（感受性期） / 刷り込み（刻印付け） / 甲状腺ホルモン / メモリープライミング / 早期学習 / BDNF / 最初期遺伝子 / ヨードチロニン脱ヨウ素酵素タイプ2 / 刷り込み / 刻印付け / ニワトリ / 学習感受性期 / 学習臨界期

Research Abstract

In some cases, learning that occurs during the sensitive or critical period lays the foundation for future learning. Filial imprinting in precocial birds is the process of forming a social attachment during a sensitive period, restricted to the first few days after hatching. We showed that the thyroid hormone(T3) determines the start of the sensitive period. Imprinting training in chicks causes rapid inflow of T3 in brain vascular endothelial cells. The T3 thus initiated and extended the sensitive period to last more than 1 week and primed subsequent learning.The mechanisms included the activation of the immediate early genes and the morphological changes of dendritic spines in brain. The timing and duration of the sensitive period for learning has been believed to be developmentally fixed.However, there is now reason to believe thatlearning itself starts the sensitive period, and once "memory priming" occurs, the sensitive period does not close but remains open.

Research Products

• [Journal Article] Potential role of voltage-sensing phosphatases in regulation of cell structure through the production of PI(3,4)P2 (2013)
  • Author(s): Yamaguchi S, Kurokawa T, Taira I, Aoki N, Sakata S, Okamura Y & Homma KJ
  • Journal Title: J. Cell Physiol. Volume: 229(4) Issue: 4 Pages: 422-33
  • DOI: 10.1002/jcp.24463
  • Peer Reviewed / Open Access
• [Journal Article] A primer for learning : thyroid hormone is a determining factor to start the sensitive period of filial imprinting of domestic chicks (2013)
  • Author(s): Homma, K.J., Yamaguchi, S. and Aoki, N.
  • Journal Title: Seikagaku Volume: 85(5)(Review, Japanese. PubMed PMID : 23819389) Pages: 315-327
  • NAID: 10031177323
  • Peer Reviewed
• [Journal Article] 鳥類の刷り込みに見られるメモリープライミング (2013)
  • Author(s): 本間光一, 山口真二, 青木直哉
  • Journal Title: 分子精神医学 Volume: 13(4) Pages: 243-250
  • Peer Reviewed
• [Journal Article] A primer for learning: thyroid hormone is a determining factor to start the sensitive period of filial imprinting of domestic chicks. (2013)
  • Author(s): Homma, K.J., Yamaguchi, S., Aoki, N..
  • Journal Title: Seikagaku Volume: 85(5) Pages: 315-327
  • NAID: 10031177323
  • Peer Reviewed
• [Journal Article] Thyroid hormone determines the start of the sensitive period of imprinting and primes later learning (2012)
  • Author(s): Yamaguchi, S., Aoki, N., Kitajima, T.Iikubo, E., Katagiri, S., Matsushima,T., Homma,K.J.
  • Journal Title: Nature Communications Volume: 3 Issue: 1 Pages: 1081-1081
  • DOI: 10.1038/ncomms2088
  • URL: http://dx.doi.org/10.1016/j.anbehav.2012.07.026
  • Peer Reviewed
• [Journal Article] 3' phosphatase activity toward PI(3,4)P2 by voltage-sensing phosphatase (2012)
  • Author(s): Kurokawa T, Takasuga S, Sakata S, Yamaguchi S, Horie S, Homma KJ, Sasaki T & Okamura Y
  • Journal Title: VSP. Proc. Natl. Acad. Sci. U.S.A. Volume: 109(25) Issue: 25 Pages: 10089-94
  • DOI: 10.1073/pnas.1203799109
  • Peer Reviewed
• [Journal Article] Activation of brain-derived neurotrophic factor (BDNF)/TrkB signaling accompanying filial imprinting in domestic chicks (Gallus gallus domesticus) (2011)
  • Author(s): Yamaguchi, S., Aoki, N., Kobayashi, D., Kitajima, T., Iikubo, E., Katagiri, S., Matsushima, T., Homma, K.-J.
  • Journal Title: NeuroReport Volume: 22 Issue: 17 Pages: 929-934
  • DOI: 10.1097/wnr.0b013e32834d0be7
  • Peer Reviewed
• [Journal Article] Activation of brain-derived neurotrophic factor/tropomyosin-related kinase B signaling accompanying filial imprinting in domestic chicks (Gallus gallus domesticus) (2011)
  • Author(s): Yamaguchi, S., Aoki, N., Kobayashi, D., Kitajima, T., Iikubo, E., Katagiri, S., Matsushima, T. and Homma K.J.
  • Journal Title: Neuroreport Volume: 22(17) Pages: 929-934
  • Peer Reviewed
• [Journal Article] Molecular function of microtubule-associated protein 2for filial imprinting in domestic chicks (Gallus gallus domesticus) (2010)
  • Author(s): Yamaguchi, S., Katagiri, S., Aoki, N., Iikubo E., Kitajima, T., Matsushima, T. , Homma,K.-J.
  • Journal Title: Neuroscience Research Volume: 69 Issue: 1 Pages: 32-40
  • DOI: 10.1016/j.neures.2010.09.002
  • NAID: 10028190047
  • Peer Reviewed
• [Presentation] Imprinting behavior in birds as a model of learning potency and the sensitive period (2014)
  • Author(s): Homma, K.J.
  • Organizer: Gordon Research Conferences, Genes & Behavior
  • Place of Presentation: Hotel Galvez in Galveston, TX, United States
• [Presentation] Imprinting behavior in birds as a model of learning potency and the sensitive period. (2014)
  • Author(s): Koichi J. Homma
  • Organizer: Gordon Research Conferences, Genes & Behavior.
  • Place of Presentation: Hotel Galvez in Galveston, TX, United States.
• [Presentation] 鳥類刻印付け感受性期の開始を決定するメモリープライミングNeuro2013 (2013)
  • Author(s): 山口真二, 青木直哉, 北島孝明, 松島俊也, 本間光一
  • Organizer: 第36回日本神経科学大会, 第56回日本神経化学会大会
  • Place of Presentation: 国立京都国際会館
  • Year and Date: 2013-06-21
• [Presentation] Imprinting primes learning : Thyroid hormone a determining factor for the sensitive period (2013)
  • Author(s): 本間光一
  • Organizer: 基礎生物学研究所国際シンポジウム"New animal models for social science"
  • Year and Date: 2013-01-24
• [Presentation] 鳥類の早期学習におけるメモリープライミング (2013)
  • Author(s): 本間光一
  • Organizer: 記憶回路研究会
  • Place of Presentation: 生理学研究所(愛知県岡崎市)
• [Presentation] "Memory priming"determines the start of the sensitive period for imprinting in birds (2013)
  • Author(s): Homma, K.J.
  • Organizer: Gordon Research Conferences, Neuroethology : Behavior, Evolution & Neurobiology
  • Place of Presentation: Mount Snow Resort in West Dover, VT, United States
• [Presentation] “Memory priming” determines the start of the sensitive period for imprinting in birds. (2013)
  • Author(s): Koichi J. Homma
  • Organizer: Gordon Research Conferences, Neuroethology: Behavior, Evolution & Neurobiology.
  • Place of Presentation: Mount Snow Resort in West Dover, VT, United States.
• [Presentation] 鳥類刻印付け感受性期の開始を決定するメモリープライミング (2013)
  • Author(s): 山口真二、青木直哉、北島孝明、松島俊也、本間光一
  • Organizer: Neuro2013(第36回日本神経科学大会、第56回日本神経化学会大会)
  • Place of Presentation: 国立京都国際会館
• [Presentation] 鳥類の早期学習におけるメモリープライミング (2013)
  • Author(s): 本間光一
  • Organizer: 記憶回路研究会
  • Place of Presentation: 生理学研究所（岡崎）
• [Presentation] Imprinting primes learning: Thyroid hormone a determining factor for the sensitive period. (2013)
  • Author(s): Homma, K. J.
  • Organizer: 基礎生物学研究所国際シンポジウム “New animal models for social science
  • Place of Presentation: 基礎生物学研究所
  • Invited
• [Presentation] Thyroid hormone determines the start of the sensitive period of visual imprinting (2012)
  • Author(s): Yamaguchi, S., Aoki, N., Kitajima, T., Matsushima, T. and Homma, K.J.
  • Organizer: Neuroscience 2012 New Orleans
  • Place of Presentation: Society for Neuroscience
  • Year and Date: 2012-10-17
• [Presentation] Rapid inflow of thyroid hormone induced by visual imprinting primes later learning. (2012)
  • Author(s): Aoki, N., Yamaguchi, S., Kitajima, T., Matsushima, T. and Homma, K.J.
  • Organizer: Neuroscience 2012 New Orleans
  • Place of Presentation: Society for Neuroscience
  • Year and Date: 2012-10-17
• [Presentation] 甲状腺ホルモンは鳥類親子刷り込みの感受性期の開始を決定する (2012)
  • Author(s): 本間光一, 山口真二, 青木直哉, 松島俊也
  • Organizer: 日本動物学会第83回大会
  • Place of Presentation: 大阪
• [Presentation] Thyroid hormone determines the start of the sensitive period of visual imprinting. (2012)
  • Author(s): S. YAMAGUCHI, N. AOKI, T. KITAJIMA, T. MATSUSHIMA, K. J. HOMMA
  • Organizer: Neuroscience 2012, Society for Neuroscience
  • Place of Presentation: New Orleans, USA
• [Presentation] Rapid inflow of thyroid hormone induced by visual imprinting primes later learning. (2012)
  • Author(s): N. AOKI, S. YAMAGUCHI, T. KITAJIMA, T. MATSUSHIMA, K. J. HOMMA
  • Organizer: Neuroscience 2012, Society for Neuroscience
  • Place of Presentation: New Orleans, USA
• [Presentation] 甲状腺ホルモンは鳥類親子刷り込みの感受性期の開始を決定する (2012)
  • Author(s): 本間 光一、山口真二、青木直哉、松島俊也
  • Organizer: 日本動物学会 第８３回大会 ２０１２大阪
  • Place of Presentation: 大阪大学
• [Presentation] ニワトリヒナ刻印付けに伴う神経栄養因子(BDNF)/TrkBシグナリングの活性化 (2011)
  • Author(s): 山口真二, 青木直哉, 小林大亮, 飯久保栄二, 松島俊也, 本間光一
  • Organizer: 第84回日本生化学会大会
  • Place of Presentation: 国立京都国際会議場
  • Year and Date: 2011-09-23
• [Presentation] Molecular/cellular mechanism of critical period in domestic chicks (2011)
  • Author(s): Homma, K.J.
  • Organizer: 日本動物学会第82回旭川大会2011 (The 82nd Annual Meeting of the Zoological Society of Japan,"Sensitive period"in imprinting, song learning and cortical plasticity)
  • Place of Presentation: 北海道、旭川
  • Year and Date: 2011-09-21
  • Invited
• [Presentation] 最初期遺伝子発現の刻印付けに伴った増加 (2011)
  • Author(s): 山口真二, 青木直哉, 北島孝明, 飯久保栄二, 松島俊也, 本間光一
  • Organizer: 34回日本神経科学大会(Neuroscience2011)
  • Place of Presentation: パシフィコ横浜
  • Year and Date: 2011-09-15
• [Presentation] Brain-derived neurotrophic factor (BDNP)/TrkB signaling is activated through filial imprinting in domestic chicks (Gallus gallus domesticus) (2011)
  • Author(s): Aoki, N., Yamaguchi, S., Kobayashi, D., Kitajima, T., Iikubo, E., Katagiri, S., Matsushima, T. and Homma, K.J.
  • Organizer: 国際比較生理生化学会議(ICCPB2011 )
  • Place of Presentation: 名古屋国際会議場
  • Year and Date: 2011-06-02
• [Presentation] Brain-derived neurotrophic factor (BDNP)/TrkB signaling is activated through filial imprinting in domestic chicks (Gallus gallus domesticus)
  • Author(s): Naoya Aoki, Shinji Yamaguchi, Daisuke Kobayashi, Takaaki Kitajima, Eiji Iikubo, Sachiko Katagiri, Toshiya Matsushima and Koichi J. Homma
  • Organizer: 国際比較生理生化学会議(ICCPB2011 )
  • Place of Presentation: 名古屋国際会議場
• [Presentation] 最初期遺伝子発現の刻印付けに伴った増加
  • Author(s): 山口真二、青木直哉、北島孝明、飯久保栄二、松島俊也、本間光一
  • Organizer: 34回日本神経科学大会(Neuroscience2011)
  • Place of Presentation: パシフィコ横浜
• [Presentation] Molecular/cellular mechanism of critical period in domestic chicks
  • Author(s): Koichi J. Homma
  • Organizer: 日本動物学会 第82回 旭川大会 2011(The 82nd Annual Meeting of the Zoological Society of Japan, "Sensitive period" in imprinting, song learning and cortical plasticity)(招待講演)
  • Place of Presentation: 北海道、旭川
• [Presentation] ニワトリヒナ刻印付けに伴う神経栄養因子(BDNF)/TrkBシグナリングの活性化
  • Author(s): 山口真二、青木直哉、小林大亮、飯久保栄二、松島俊也、本間光一
  • Organizer: 第84回日本生化学会大会
  • Place of Presentation: 国立京都国際会議場
• [Book] Insect papain homologues In Handbook of Proteolytic Enzyme, 3^<rd> Edition (2012)
  • Author(s): Homma, K. J., Yamaguchi, S. and Aoki, N.
  • Publisher: Academic Press(A.J. Barrett, N.D. Rawlings and J.D. Woessner, eds)
• [Book] Handbook of Proteolytic Enzyme, 3rd Edition ( A. J. Barrett, N. D. Rawlings, and J. D. Woessner, eds) (2012)
  • Author(s): Homma, K. J. , Yamaguchi, S. and Aoki, N.
  • Publisher: Academic Press
• [Book] 生物学辞典 (2011)
  • Author(s): 本間光一
  • Total Pages: 1615
  • Publisher: 東京化学同人(石川統、黒川常祥ら編集)
• [Book] 生物学辞典 (2011)
  • Author(s): 本間光一（石川統、黒川常祥ら編集）
  • Total Pages: 1615
  • Publisher: 東京化学同人
• [Remarks] 帝京大学薬学部ホームページ
  • URL: http://www.pharm.teikyo-u.ac.jp/
• [Remarks] 帝京大学教員情報
  • URL: https://www.e-campus.gr.jp/staffinfo/public/staff/detail/450/16
• [Remarks] 帝京大学薬学部ホームページ
  • URL: http://www.pharm.teikyo-u.ac.jp/
• [Remarks] 帝京大学教員情報
  • URL: https://www.e-campus.gr.jp/staffinfo/public/staff/detail/450/16
• [Remarks] 帝京大学薬学部ホームページ
  • URL: http://www.pharm.teikyo-u.ac.jp/
• [Remarks] 帝京大学ホームページ薬学部教員紹介ページ
  • URL: http://www.e-campus.gr.jp/staffinfo/public/staff/detail/450/16