Functional analysis of a neurohypophysial hormone using transgenic ascidian ovaries
| Project/Area Number |
23570100
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Animal physiology/Animal behavior
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| Research Institution | Suntory Foundation for Life Sciences |
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Principal Investigator |
KAWADA TSUYOSHI 公益財団法人サントリー生命科学財団, その他部局等, 研究員 (90300821)
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| Co-Investigator(Renkei-kenkyūsha) |
SATAKE Honoo 公益財団法人サントリー生命科学財団, 生物有機科学研究所, 研究部長 (20280688)
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| Project Period (FY) |
2011 – 2013
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| Project Status |
Completed (Fiscal Year 2013)
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| Budget Amount *help |
¥5,330,000 (Direct Cost: ¥4,100,000、Indirect Cost: ¥1,230,000)
Fiscal Year 2013: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2012: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2011: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
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| Keywords | オキシトシン / バソプレシン / 生理活性 / カタユウレイボヤ |
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| Research Abstract |
Ci-VP is an oxytocin/vasopressin superfamily peptide identified from an ascidian, Ciona intestinalis. We generated a transgenic ascidian that contains Ci-VP promoter region conjugated with a fluorescence protein gene. The Ci-VP promoter-regulated fluorescence protein was detected in the ovary of the young transgenic ascidian. Indeed, Ci-VP mRNA was also detected in the ovary of wild young ascidians, and several small cells in the ovary contain Ci-VP mRNA. Moreover, administration of Ci-VP to the ovary of young ascidians induced expression of several genes promoting cell prolification. These results suggest that Ci-VP serves as not only a neuropeptide but also an ovarian factor involved in the development or maturation of the ovary.
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Report
(4 results)
Research Products
(28 results)
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[Journal Article] Peptidomic analysis of the central nervous system of the protochordate, Ciona intestinalis : homologs and prototypes of vertebrate peptides and novel peptides2011
Author(s)
Kawada, T., Ogasawara, M., Sekiguchi, T., Aoyama, M., Hotta, K., Oka, K, Satake, H.
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Journal Title
Endocrinology
Volume: 152
Issue: 6
Pages: 2416-2427
DOI
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[Book] "Structure, function, and evolutionary aspects of invertebrate GnRHs and their receptors."In : Gonadotropin-Releasing Hormone (GnRH): Production, Structure and Functions2013
Author(s)
Kawada, T., Aoyama, M., Sakai, T., Satake, H.
Publisher
Nova Science Publishers Inc., NY, USA.
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[Book] Recent Research Developments in Endocrinology, Vol. 52012
Author(s)
Satake, H., Sekiguchi, T., Sakai, T., Aoyama, M., Kawada, T.
Total Pages
19
Publisher
Research Signpost
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[Book] "Ascidians : new model orgnanisms for reproductive endocrinology"In : Endocrinology Book 22011
Author(s)
Satake, H., Kawada, T., Aoyama, M., Sekiguchi, T., Sakai, T.
Publisher
IN-TECH, Vienna, Austria
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[Book] Update on Mechanisms of Hormone Action - Focus on Metabolism, Growth and Reproductions2011
Author(s)
Satake, H., Kawada, T., Aoyama, M., Sekiguchi, T., Sakai, T.
Total Pages
24
Publisher
InTech
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