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Causes of fragile testes revealed by evolutionary studies of gene expression regulation

Research Project

Project/Area Number 23570123
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field Biodiversity/Systematics
Research InstitutionKyoto Institute of Technology (2012-2013)
National Institute of Genetics (2011)

Principal Investigator

TAKANO Toshiyuki  京都工芸繊維大学, ショウジョウバエ遺伝資源センター, 教授 (90202150)

Project Period (FY) 2011 – 2013
Project Status Completed (Fiscal Year 2013)
Budget Amount *help
¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000)
Fiscal Year 2013: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2012: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2011: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Keywords種分化 / 分子共進化 / ショウジョウバエ / 遺伝子発現 / シス調節因子 / トランス制御因子 / 進化 / 遺伝学 / 共進化 / トランス調節因子
Research Abstract

Spermatogenesis defects are frequently observed in interspecific hybrids of Drosophila. Indeed, hybrid male sterility evolves much faster than female sterility. To understand how the hybrid sterility can arise so quickly, we characterized the expression profile of testes of Drosophila melanogaster and found that transcribed and translated genes tended significantly to cluster. More importantly, genes exhibiting strain-specific higher or lower expression also tended to cluster. It is conceivable that testis transcription is not strictly controlled and therefore that the testis possesses many noisy transcripts. On the other hand, by using interspecific hybrids, we obtained evidence that hybrid incompatibilities between cis- and trans-regulatory elements are accumulating much faster than generally considered. Taken together, we proposed that regulatory incompatibilities contribute to the fast evolution of hybrid male sterility.

Report

(4 results)
  • 2013 Annual Research Report   Final Research Report ( PDF )
  • 2012 Research-status Report
  • 2011 Research-status Report
  • Research Products

    (34 results)

All 2014 2013 2012 2011 Other

All Journal Article (11 results) (of which Peer Reviewed: 11 results) Presentation (20 results) (of which Invited: 3 results) Book (1 results) Remarks (2 results)

  • [Journal Article] A novel cell death gene acts to repair patterning defects in Drosophila melanogaster2014

    • Author(s)
      Tanaka, K. M., Takahashi, A., Fuse, N., and Takano-Shimizu-Kouno, T.
    • Journal Title

      Genetics

      Volume: 197 (in press)

    • Related Report
      2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] Allelic asymmetry of the Lethal hybrid rescue (Lhr) gene expression in the hybrid between Drosophila melanogaster and D. simulans : confirmation by using genetic variations of D. melanogaster2014

    • Author(s)
      Shirata, M., Araye, Q., Maehara, K., Enya, S., Takano-Shimizu, T., and Sawamura, K.
    • Journal Title

      Genetica

      Volume: 142 Issue: 1 Pages: 43-48

    • DOI

      10.1007/s10709-013-9752-3

    • Related Report
      2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] Allelic asymmetry of the Lethal hybrid rescue (Lhr) gene expression in the hybrid between Drosophila melanogaster and D. simulans: confirmation by using genetic variations of D. melanogaster.2014

    • Author(s)
      Shirata, M., Araye, Q., Maehara, K., Enya, S., Takano-Shimizu, T., and Sawamura, K.
    • Journal Title

      Genetica

      Volume: 142 Pages: 43-48

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Journal Article] A novel cell death gene acts to repair patterning defects in Drosophila melanogaster.2014

    • Author(s)
      Tanaka, K. M., Takahashi, A., Fuse, N., and Takano-Shimizu-Kouno, T.
    • Journal Title

      Genetics

      Volume: 197

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Genomic Mixing to Elucidate the Genetic System of Complex Traits2012

    • Author(s)
      Koide, T., Goto, T., and Takano-Shimizu T.
    • Journal Title

      Experimental Animals

      Volume: 61 Issue: 5 Pages: 503-509

    • DOI

      10.1538/expanim.61.503

    • NAID

      10031121854

    • ISSN
      0007-5124, 1341-1357, 1881-7122
    • Related Report
      2013 Final Research Report 2012 Research-status Report
    • Peer Reviewed
  • [Journal Article] Starvation-induced elevation of taste responsiveness and expression of a sugar taste receptor gene in Drosophila melanogaster.2012

    • Author(s)
      Nishimura, A., Ishida, Y., Takahashi, A., Okamoto, H., Sakabe, M., Itoh, M., Takano-Shimizu, T., and Ozaki M.
    • Journal Title

      Journal of Neurogenetics

      Volume: 26 Issue: 2 Pages: 206-215

    • DOI

      10.3109/01677063.2012.694931

    • Related Report
      2013 Final Research Report 2012 Research-status Report
    • Peer Reviewed
  • [Journal Article] Cuticular hydrocarbon content that affects male mate preference of Drosophila melanogaster from West Africa2012

    • Author(s)
      Takahashi, A., et al
    • Journal Title

      Int.J.Evol.Biol.

      Volume: 2012 Pages: 278903-278903

    • DOI

      10.1155/2012/278903

    • Related Report
      2013 Final Research Report 2012 Research-status Report
    • Peer Reviewed
  • [Journal Article] Two types of cis-trans compensation in the evolution of transcriptional regulation2011

    • Author(s)
      Takahashi KR, Matsuo T, Takano-Shimizu-Kouno T.
    • Journal Title

      Proceedings of National Academy of Science USA

      Volume: 108 Issue: 37 Pages: 15276-15281

    • DOI

      10.1073/pnas.1105814108

    • Related Report
      2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] Divergent enhancer haplotype of ebony on inversion In(3R)Payne associated with pigmentation variation in a tropical population of Drosophila melanogaster2011

    • Author(s)
      Takahashi, A., Takano-Shimizu, T.
    • Journal Title

      Mol.Ecol.

      Volume: 20 Issue: 20 Pages: 4277-87

    • DOI

      10.1111/j.1365-294x.2011.05260.x

    • Related Report
      2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] Two types of cis-trans compensation in the evolution of transcriptional regulation.2011

    • Author(s)
      Takahasi, K. R., Matsuo, T., and Takano-Shimizu-Kouno, T.
    • Journal Title

      Proceedings of the National Academy of Sciences of the United States of America

      Volume: 108 Pages: 15276-15281

    • Related Report
      2011 Research-status Report
    • Peer Reviewed
  • [Journal Article] Divergent enhancer haplotype of ebony on inversion In(3R)Payne associated with pigmentation variation in a tropical population of Drosophila melanogaster.2011

    • Author(s)
      Takahashi, A., and Takano-Shimizu, T.
    • Journal Title

      Molecular Ecology

      Volume: 20 Pages: 4277-4287

    • Related Report
      2011 Research-status Report
    • Peer Reviewed
  • [Presentation] Gene expression profiling of Drosophila testis2014

    • Author(s)
      Takano-Shimizu, T.
    • Organizer
      55th Annual Drosophila Research Conference
    • Place of Presentation
      米国サンディエゴ
    • Related Report
      2013 Final Research Report
  • [Presentation] Gene Expression Profiling of Testis in Drosophila melanogaster2014

    • Author(s)
      Takano-Shimizu, T.
    • Organizer
      SMBE satellite Meeting, NIG International Symposium : The Causes of Genome Evolution
    • Place of Presentation
      国立遺伝学研究所,三島市
    • Related Report
      2013 Final Research Report
  • [Presentation] Gene expression profiling of testis in Drosophila melanogaster.2014

    • Author(s)
      Takano-Shimizu, T.
    • Organizer
      SMBE satellite Meeting, NIG International Symposium: The Causes of Genome Evolution
    • Place of Presentation
      国立遺伝学研究所
    • Related Report
      2013 Annual Research Report
    • Invited
  • [Presentation] Gene expression profiling of Drosophila testis.2014

    • Author(s)
      Takano-Shimizu, T., Tomaru, M., and Watanabe, M.
    • Organizer
      55th Annual Drosophila Research Conference
    • Place of Presentation
      米国サンディエゴ
    • Related Report
      2013 Annual Research Report
  • [Presentation] 子どもを作れないオス,その理由を解く−脆弱な精巣の遺伝子発現プロファイリング2013

    • Author(s)
      高野敏行
    • Organizer
      第3回4大学連携研究フォーラム
    • Place of Presentation
      京都医科大学,京都
    • Year and Date
      2013-12-09
    • Related Report
      2013 Final Research Report
  • [Presentation] Genomesから掬う細胞内の変化2013

    • Author(s)
      高野敏行
    • Organizer
      ショウジョウバエ多様性研究会ミニシンポ
    • Place of Presentation
      国立遺伝学研究所
    • Year and Date
      2013-09-30
    • Related Report
      2013 Final Research Report
  • [Presentation] 生命システムの頑健性(ロバストネス)の遺伝基盤2013

    • Author(s)
      高野敏行
    • Organizer
      九州大学・システム生命科学府セミナー
    • Place of Presentation
      九州大学,福岡
    • Year and Date
      2013-07-05
    • Related Report
      2013 Final Research Report
  • [Presentation] Expression noise in the Drosophila testes2013

    • Author(s)
      Takano-Shimizu, T.
    • Organizer
      国立遺伝学研究所ワークショップ「Evolution of Junk DNA」
    • Place of Presentation
      国立遺伝学研究所,三島市
    • Year and Date
      2013-06-22
    • Related Report
      2013 Final Research Report
  • [Presentation] キイロショウジョウバエ精巣の遺伝子発現プロファイリング2013

    • Author(s)
      都丸雅敏
    • Organizer
      日本遺伝学会第85回大会
    • Place of Presentation
      慶応大学,東京
    • Related Report
      2013 Final Research Report
  • [Presentation] 野生由来ヘテロジニアスストックマウス作製過程におけるアレル頻度のシミュレーション2013

    • Author(s)
      小出剛,高野敏行,後藤逹彦
    • Organizer
      第60回日本実験動物学会総会
    • Place of Presentation
      つくば国際会議場
    • Related Report
      2013 Annual Research Report
  • [Presentation] Gene expression noise in the Drosophila testes.2013

    • Author(s)
      Takano, T.
    • Organizer
      NIG Meeting: Evolution of Junk DNAs
    • Place of Presentation
      国立遺伝学研究所
    • Related Report
      2013 Annual Research Report
    • Invited
  • [Presentation] キイロショウジョウバエ精巣の遺伝子発現プロファイリング2013

    • Author(s)
      都丸 雅敏,渡邉 昌秀,高野 敏行
    • Organizer
      日本遺伝学会第85回大会
    • Place of Presentation
      慶應義塾大学日吉キャンパス
    • Related Report
      2013 Annual Research Report
  • [Presentation] ショウジョウバエ雑種致死救済効果を抑制する遺伝子の解析2013

    • Author(s)
      白田 美香,新井 健太,前原 一慶,塩谷 天,高野 敏行,澤村 京一
    • Organizer
      日本遺伝学会第85回大会
    • Place of Presentation
      慶應義塾大学日吉キャンパス
    • Related Report
      2013 Annual Research Report
  • [Presentation] Genomes から掬う細胞内の変化2013

    • Author(s)
      高野敏行
    • Organizer
      ショウジョウバエ多様性研究会ミニシンポ
    • Place of Presentation
      国立遺伝学研究所
    • Related Report
      2013 Annual Research Report
    • Invited
  • [Presentation] 子どもを作れないオス,その理由を解く-脆弱な精巣の遺伝子発現プロファイリング2013

    • Author(s)
      高野敏行,都丸雅敏,渡邉昌秀
    • Organizer
      第3回4大学連携研究フォーラム
    • Place of Presentation
      京都府立医科大学
    • Related Report
      2013 Annual Research Report
  • [Presentation] Two types of cis-trans compensation in the evolution of transcriptional regulation2012

    • Author(s)
      Takano-Shimizu, T.
    • Organizer
      The 53rd Annual Drosophila Research Conference
    • Place of Presentation
      米国シカゴ
    • Related Report
      2013 Final Research Report
  • [Presentation] A Diptera specific cell death gene: compensatory cell death for head expansion in Drosophila melanogaster.2012

    • Author(s)
      Tanaka, K. M., Takahashi, A., Fuse, N., and Takano-Shimizu-Kouno, T.
    • Organizer
      The fourth meeting of the European Society for Evolutionary Developmental Biology (EED)
    • Place of Presentation
      Lisbon, Portugal
    • Related Report
      2012 Research-status Report
  • [Presentation] シュウジョウバエ複眼サイズの変異メカニズム2012

    • Author(s)
      高野敏行、鈴木えみ子
    • Organizer
      日本遺伝学会第84回大会
    • Place of Presentation
      福岡
    • Related Report
      2012 Research-status Report
  • [Presentation] Two types of cis-trans compensation in the evolution of transcriptional regulation2012

    • Author(s)
      Takano-Shimizu, T., Takahasi, K. R., and Matsuo T.
    • Organizer
      2012 Annual Drosophila Research Conference
    • Place of Presentation
      Chicago, U.S.A.
    • Related Report
      2011 Research-status Report
  • [Presentation] Association between color and behavior in a natural population of Drosophila melanogaster2011

    • Author(s)
      Takahashi, A., and Takano-Shimizu, T.
    • Organizer
      1st Asia-Pacific Drosophila Research Conference
    • Place of Presentation
      Taipei, Taiwan
    • Related Report
      2011 Research-status Report
  • [Book] 遺伝子図鑑2013

    • Author(s)
      斎藤成也 他
    • Publisher
      悠書館
    • Related Report
      2013 Final Research Report
  • [Remarks] 高野・都丸 研究室

    • URL

      http://www.dgrc.kit.ac.jp/research/index.html

    • Related Report
      2013 Annual Research Report
  • [Remarks] 高野・都丸 研究室

    • URL

      http://www.dgrc.kit.ac.jp/research/research.html

    • Related Report
      2012 Research-status Report

URL: 

Published: 2011-08-05   Modified: 2019-07-29  

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