| Budget Amount *help |
¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000)
Fiscal Year 2013: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2012: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2011: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
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| Research Abstract |
Spermatogenesis defects are frequently observed in interspecific hybrids of Drosophila. Indeed, hybrid male sterility evolves much faster than female sterility. To understand how the hybrid sterility can arise so quickly, we characterized the expression profile of testes of Drosophila melanogaster and found that transcribed and translated genes tended significantly to cluster. More importantly, genes exhibiting strain-specific higher or lower expression also tended to cluster. It is conceivable that testis transcription is not strictly controlled and therefore that the testis possesses many noisy transcripts. On the other hand, by using interspecific hybrids, we obtained evidence that hybrid incompatibilities between cis- and trans-regulatory elements are accumulating much faster than generally considered. Taken together, we proposed that regulatory incompatibilities contribute to the fast evolution of hybrid male sterility.
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