Causes of fragile testes revealed by evolutionary studies of gene expression regulation
| Project/Area Number |
23570123
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Biodiversity/Systematics
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| Research Institution | Kyoto Institute of Technology (2012-2013)
National Institute of Genetics (2011) |
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Principal Investigator |
TAKANO Toshiyuki 京都工芸繊維大学, ショウジョウバエ遺伝資源センター, 教授 (90202150)
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| Project Period (FY) |
2011 – 2013
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| Project Status |
Completed (Fiscal Year 2013)
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| Budget Amount *help |
¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000)
Fiscal Year 2013: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2012: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2011: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
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| Keywords | 種分化 / 分子共進化 / ショウジョウバエ / 遺伝子発現 / シス調節因子 / トランス制御因子 / 進化 / 遺伝学 / 共進化 / トランス調節因子 |
|---|
| Research Abstract |
Spermatogenesis defects are frequently observed in interspecific hybrids of Drosophila. Indeed, hybrid male sterility evolves much faster than female sterility. To understand how the hybrid sterility can arise so quickly, we characterized the expression profile of testes of Drosophila melanogaster and found that transcribed and translated genes tended significantly to cluster. More importantly, genes exhibiting strain-specific higher or lower expression also tended to cluster. It is conceivable that testis transcription is not strictly controlled and therefore that the testis possesses many noisy transcripts. On the other hand, by using interspecific hybrids, we obtained evidence that hybrid incompatibilities between cis- and trans-regulatory elements are accumulating much faster than generally considered. Taken together, we proposed that regulatory incompatibilities contribute to the fast evolution of hybrid male sterility.
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Report
(4 results)
Research Products
(34 results)
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[Journal Article] Allelic asymmetry of the Lethal hybrid rescue (Lhr) gene expression in the hybrid between Drosophila melanogaster and D. simulans : confirmation by using genetic variations of D. melanogaster2014
Author(s)
Shirata, M., Araye, Q., Maehara, K., Enya, S., Takano-Shimizu, T., and Sawamura, K.
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Journal Title
Genetica
Volume: 142
Issue: 1
Pages: 43-48
DOI
Related Report
Peer Reviewed
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[Journal Article] Allelic asymmetry of the Lethal hybrid rescue (Lhr) gene expression in the hybrid between Drosophila melanogaster and D. simulans: confirmation by using genetic variations of D. melanogaster.2014
Author(s)
Shirata, M., Araye, Q., Maehara, K., Enya, S., Takano-Shimizu, T., and Sawamura, K.
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Journal Title
Genetica
Volume: 142
Pages: 43-48
Related Report
Peer Reviewed
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[Journal Article] Starvation-induced elevation of taste responsiveness and expression of a sugar taste receptor gene in Drosophila melanogaster.2012
Author(s)
Nishimura, A., Ishida, Y., Takahashi, A., Okamoto, H., Sakabe, M., Itoh, M., Takano-Shimizu, T., and Ozaki M.
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Journal Title
Journal of Neurogenetics
Volume: 26
Issue: 2
Pages: 206-215
DOI
Related Report
Peer Reviewed
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