Regulation of neural functions via polySia and FGF2 interaction
| Project/Area Number |
23570133
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Structural biochemistry
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| Research Institution | Nagoya University |
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Principal Investigator |
SATO Chihiro 名古屋大学, 生物機能開発利用研究センター, 准教授 (10343211)
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| Project Period (FY) |
2011 – 2013
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| Project Status |
Completed (Fiscal Year 2013)
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| Budget Amount *help |
¥5,460,000 (Direct Cost: ¥4,200,000、Indirect Cost: ¥1,260,000)
Fiscal Year 2013: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2012: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2011: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
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| Keywords | ポリシアル酸 / NCAM / ポリシアル酸転移酵素 / FGF2 / 細胞増殖 / ヘパラン硫酸 / 分子間力相互作用 / 神経 / 統合失調症 / 分子間相互作用 / 増殖因子 / 酸性多糖 / FGF / BDNF |
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| Research Abstract |
Polysialic acid (polySia) is a homopolymer of sialic acid with the degree of polymerization 8-400 Sia residues. PolySia is highly expressed on the neural cell adhesion molecule (NACM) in embryonic brains. In adult, polySia mostly disappeared; however, it persists in distinct regions such as hippocampus, subventricular zone, thalamus, prefrontal cortex and amygdala, where neural plasticity, remodeling of neural connections or neural generation are ongoing. PolySia on NCAM is known to have anti-adhesive effects on cell-cell interactions due to its bulky polyanionic nature and is involved in regulation of neurogenesis and neuronal functions. In this study, we demonstrate that polySia functions as a reservoir scaffold for various molecules of neurological active molecules, such as fibroblast growth factor 2 (FGF2).
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Report
(4 results)
Research Products
(157 results)
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[Journal Article] Pig sperm membrane microdomains contain a highly glycosylated 15-25-kDa wheat germ agglutinin-binding protein2012
Author(s)
Kasekarn W, Kanazawa T, Hori K, Tsuchiyama T, Xue L, Garénaux E, Kongmanas K, Tanphaichitr N, Yasue H, Sato C, Kitajima K.
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Journal Title
Biochem. Biophys. Res. Commun.
Volume: 426(3)
Pages: 356-362
Related Report
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[Journal Article] Sialidase NEU4 hydrolyzes polysialic acids of neural cell adhesion molecules and negatively regulates neurite formation by hippocampal neurons2012
Author(s)
Takahashi K, Mitoma J, Hosono M, Shiozaki K, Sato C, Yamaguchi K, Kitajima K, Higashi H, Nitta K, Shima H, Miyagi T.
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Journal Title
J Biol Chem.
Volume: 287(18)
Pages: 14816-14826
Related Report
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[Journal Article] Metabolism of Vertebrate Amino Sugars with N-glycolyl Groups : Resistance ofα2-8-linked N-glycolylneuraminic Acid to Enzymatic Cleavage2012
Author(s)
Davies LRL, Pearce OMT, Tessier MB, Assar S, Smutova V, Pajunen M, Sumida M, Sato C, Kitajima K, Finne J, Gagneux P, Pshezhetsky A, Woods R, Varki A.
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Journal Title
J Biol Chem.
Volume: 287(34)
Pages: 28917-28931
Related Report
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[Journal Article] Pig sperm membrane microdomains contain a highly glycosylated 15–25-kDa wheat germ agglutinin-binding protein.2012
Author(s)
Waraporn Kasekarn, Takeru Kanazawa, Kazuki Hori, Tomoyuki, Tsuchiyama, Xue Lian, Estelle Garénaux, Kessiri Kongmanas, Nongnuj Tanphaichitr, Hiroshi Yasue, Chihiro Sato and Ken Kitajima
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Journal Title
Biochem. Biophys. Res. Commun.
Volume: 426
Pages: 356-362
Related Report
Peer Reviewed
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[Journal Article] Metabolism of vertebrate amino sugars with N-glycolyl groups: Resistance of α2-8-linked N-glycolylneuraminic Acid to Enzymatic Cleavage.2012
Author(s)
Davies, L.,Pearce, O., Tessier, M., Assar M., Smutova, V., Pajunen, M., Sumida, M., Sato, C., Kitajima, K., Finne, J., Gagneux,P., Pshezhetsky, A., Woods, R., and Varki A.
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Journal Title
J Biol Chem.
Volume: 287
Issue: 34
Pages: 28917-28931
DOI
Related Report
Peer Reviewed
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[Presentation] Extensive incorporation2011
Author(s)
Sadako Inoue, Chihiro Sato, and Ken Kitajima.
Organizer
International Symposium on Glycoconjugates
Place of Presentation
The University of Vienna, Vienna, Austria.
Related Report
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