Research Project
Grant-in-Aid for Scientific Research (C)
Polysialic acid (polySia) is a homopolymer of sialic acid with the degree of polymerization 8-400 Sia residues. PolySia is highly expressed on the neural cell adhesion molecule (NACM) in embryonic brains. In adult, polySia mostly disappeared; however, it persists in distinct regions such as hippocampus, subventricular zone, thalamus, prefrontal cortex and amygdala, where neural plasticity, remodeling of neural connections or neural generation are ongoing. PolySia on NCAM is known to have anti-adhesive effects on cell-cell interactions due to its bulky polyanionic nature and is involved in regulation of neurogenesis and neuronal functions. In this study, we demonstrate that polySia functions as a reservoir scaffold for various molecules of neurological active molecules, such as fibroblast growth factor 2 (FGF2).
All 2014 2013 2012 2011 Other
All Journal Article (28 results) (of which Peer Reviewed: 18 results) Presentation (121 results) (of which Invited: 9 results) Book (4 results) Remarks (4 results)
Front. Cell. Neurosci.
Volume: 7 Pages: 1-11
10.3389/fncel.2013.00061
J Biochem (Tokyo)
Volume: 154 Issue: 2 Pages: 115-136
10.1093/jb/mvt057
Bioorg. Med. Chem.
Volume: 21 Issue: 19 Pages: 6069-76
10.1016/j.bmc.2013.07.023
Journal of Biological Chemistry
Volume: 288 Issue: 47 Pages: 33784-33796
10.1074/jbc.m113.496224
Glycobiology
Volume: 23 Issue: 6 Pages: 634-642
10.1093/glycob/cws132
実験医学
Volume: 31 Pages: 26-33
J Biol Chem.
Volume: 287(6) Pages: 3710-3722
Biochem. Biophys. Res. Commun.
Volume: 426(3) Pages: 356-362
Volume: 22(4) Pages: 479-491
479 Pure Appl Chem.
Volume: 84(9) Pages: 1895-1906
Volume: 287(18) Pages: 14816-14826
Volume: 287(34) Pages: 28917-28931
Volume: 287 Issue: 6 Pages: 3710-3722
10.1074/jbc.m111.276618
Pure Appl Chem.
Volume: 84 Issue: 9 Pages: 1895-1906
10.1351/pac-con-11-12-10
Volume: 426 Pages: 356-362
Volume: 287 Issue: 34 Pages: 28917-28931
10.1074/jbc.m112.365056
Volume: 22 Issue: 4 Pages: 479-491
10.1093/glycob/cwr155
Volume: 287 Issue: 18 Pages: 14816-14826
10.1074/jbc.m111.324186
J. Biol. Chem.
Volume: 286(24)
Volume: 21(12) Pages: 1596-1605
Adv Exp Med Biol.
Volume: 705 Pages: 669-678
Cell Struct Funct.
Volume: 36(1) Pages: 69-82
130004137565
Volume: 286 Pages: 21535-21545
Volume: 21 Pages: 1596-1605
Volume: 36 Pages: 69-82
Seikagaku
Volume: 83 Pages: 189-196
Trends Glycsci Glycotech
Volume: 23 Pages: 221-238
http://jcggdb.jp/GlycoPOD/protocolShow.action?nodeId=t223