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Regulation of neural functions via polySia and FGF2 interaction

Research Project

Project/Area Number 23570133
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field Structural biochemistry
Research InstitutionNagoya University

Principal Investigator

SATO Chihiro  名古屋大学, 生物機能開発利用研究センター, 准教授 (10343211)

Project Period (FY) 2011 – 2013
Project Status Completed (Fiscal Year 2013)
Budget Amount *help
¥5,460,000 (Direct Cost: ¥4,200,000、Indirect Cost: ¥1,260,000)
Fiscal Year 2013: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2012: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2011: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
Keywordsポリシアル酸 / NCAM / ポリシアル酸転移酵素 / FGF2 / 細胞増殖 / ヘパラン硫酸 / 分子間力相互作用 / 神経 / 統合失調症 / 分子間相互作用 / 増殖因子 / 酸性多糖 / FGF / BDNF
Research Abstract

Polysialic acid (polySia) is a homopolymer of sialic acid with the degree of polymerization 8-400 Sia residues. PolySia is highly expressed on the neural cell adhesion molecule (NACM) in embryonic brains. In adult, polySia mostly disappeared; however, it persists in distinct regions such as hippocampus, subventricular zone, thalamus, prefrontal cortex and amygdala, where neural plasticity, remodeling of neural connections or neural generation are ongoing. PolySia on NCAM is known to have anti-adhesive effects on cell-cell interactions due to its bulky polyanionic nature and is involved in regulation of neurogenesis and neuronal functions. In this study, we demonstrate that polySia functions as a reservoir scaffold for various molecules of neurological active molecules, such as fibroblast growth factor 2 (FGF2).

Report

(4 results)
  • 2013 Annual Research Report   Final Research Report ( PDF )
  • 2012 Research-status Report
  • 2011 Research-status Report
  • Research Products

    (157 results)

All 2014 2013 2012 2011 Other

All Journal Article (28 results) (of which Peer Reviewed: 18 results) Presentation (121 results) (of which Invited: 9 results) Book (4 results) Remarks (4 results)

  • [Journal Article] Impact of structural aberrancy of polysialic acid and its synthetic enzyme ST8SIA2 in schizophrenia.2013

    • Author(s)
      Sato C, Kitajima K.
    • Journal Title

      Front. Cell. Neurosci.

      Volume: 7 Pages: 1-11

    • DOI

      10.3389/fncel.2013.00061

    • Related Report
      2013 Annual Research Report 2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] Disialic, oligosialic, and polysialic acids: Distribution, biological functions, and related disease.2013

    • Author(s)
      Sato C., Kitajima K.
    • Journal Title

      J Biochem (Tokyo)

      Volume: 154 Issue: 2 Pages: 115-136

    • DOI

      10.1093/jb/mvt057

    • Related Report
      2013 Annual Research Report 2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] NMR study into the mechanism of recognition of the degree of polymerization by oligo/polysialic acid antibodies.2013

    • Author(s)
      Hanashima S, Sato C, Tanaka H, Takahashi T, Kitajima K, Yamaguchi Y.
    • Journal Title

      Bioorg. Med. Chem.

      Volume: 21 Issue: 19 Pages: 6069-76

    • DOI

      10.1016/j.bmc.2013.07.023

    • Related Report
      2013 Annual Research Report 2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] Crystal structure of anti-polysialic acid antibody single chain Fv fragment complexed with octasialic acid : insight into the binding preference for polysialic acid.2013

    • Author(s)
      Nagae M, Ikeda A, Halle M, Hanashima S, Kitajima K, Sato C, Yamaguchi Y.
    • Journal Title

      Journal of Biological Chemistry

      Volume: 288 Issue: 47 Pages: 33784-33796

    • DOI

      10.1074/jbc.m113.496224

    • Related Report
      2013 Annual Research Report 2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] Occurrence of free deaminoneuraminic acid (KDN)-containing complex-type N-glycans in human prostate cancers.2013

    • Author(s)
      Yabu M, Korekane H, Takahashi H, Ohigashi H, Ishikawa O, Hatano K, Nonomura N, Sato C, Kitajima K, Miyamoto Y.
    • Journal Title

      Glycobiology

      Volume: 23 Issue: 6 Pages: 634-642

    • DOI

      10.1093/glycob/cws132

    • Related Report
      2013 Annual Research Report 2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] ポリシアル酸による神経機能の調節. 実験医学 31巻 10号 (増刊) pp. 26-33; 第三の生命鎖2013

    • Author(s)
      佐藤ちひろ、北島健
    • Journal Title

      実験医学

      Volume: 31 Pages: 26-33

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Novel regulation of fibroblast growth factor 2 (FGF2)-mediated cell growth by polysialic acid2012

    • Author(s)
      Ono S, Hane M, Kitajima K, Sato C.
    • Journal Title

      J Biol Chem.

      Volume: 287(6) Pages: 3710-3722

    • Related Report
      2013 Final Research Report
  • [Journal Article] Pig sperm membrane microdomains contain a highly glycosylated 15-25-kDa wheat germ agglutinin-binding protein2012

    • Author(s)
      Kasekarn W, Kanazawa T, Hori K, Tsuchiyama T, Xue L, Garénaux E, Kongmanas K, Tanphaichitr N, Yasue H, Sato C, Kitajima K.
    • Journal Title

      Biochem. Biophys. Res. Commun.

      Volume: 426(3) Pages: 356-362

    • Related Report
      2013 Final Research Report
  • [Journal Article] Sialome analysis of the cephalochordate Branchiostoma belcheri, a key organism for vertebrate evolution2012

    • Author(s)
      Guérardel Y, Chang LY, Fujita A, Coddeville B, Maes E, Sato C, Harduin-Lepers A, Kubokawa K, Kitajima K.
    • Journal Title

      Glycobiology

      Volume: 22(4) Pages: 479-491

    • Related Report
      2013 Final Research Report
  • [Journal Article] Structural and functional impairments of polySia-NCAM synthesized by a mutated polysialyltransferase of a schizophrenic patient2012

    • Author(s)
      Hane M, Sumida M, Kitajima K, Sato C.
    • Journal Title

      479 Pure Appl Chem.

      Volume: 84(9) Pages: 1895-1906

    • Related Report
      2013 Final Research Report
  • [Journal Article] Sialidase NEU4 hydrolyzes polysialic acids of neural cell adhesion molecules and negatively regulates neurite formation by hippocampal neurons2012

    • Author(s)
      Takahashi K, Mitoma J, Hosono M, Shiozaki K, Sato C, Yamaguchi K, Kitajima K, Higashi H, Nitta K, Shima H, Miyagi T.
    • Journal Title

      J Biol Chem.

      Volume: 287(18) Pages: 14816-14826

    • Related Report
      2013 Final Research Report
  • [Journal Article] Metabolism of Vertebrate Amino Sugars with N-glycolyl Groups : Resistance ofα2-8-linked N-glycolylneuraminic Acid to Enzymatic Cleavage2012

    • Author(s)
      Davies LRL, Pearce OMT, Tessier MB, Assar S, Smutova V, Pajunen M, Sumida M, Sato C, Kitajima K, Finne J, Gagneux P, Pshezhetsky A, Woods R, Varki A.
    • Journal Title

      J Biol Chem.

      Volume: 287(34) Pages: 28917-28931

    • Related Report
      2013 Final Research Report
  • [Journal Article] Novel regulation of fibroblast growth factor 2 (FGF2)-mediated cell growth by polysialic acid.2012

    • Author(s)
      Ono S, Hane M, Kitajima K, Sato C.
    • Journal Title

      J Biol Chem.

      Volume: 287 Issue: 6 Pages: 3710-3722

    • DOI

      10.1074/jbc.m111.276618

    • Related Report
      2012 Research-status Report
    • Peer Reviewed
  • [Journal Article] Structural and functional impairments of polySia-NCAM synthesized by a mutated polysialyltransferase of a schizophrenic patient.2012

    • Author(s)
      Hane M, Sumida M, Kitajima K, Sato C.
    • Journal Title

      Pure Appl Chem.

      Volume: 84 Issue: 9 Pages: 1895-1906

    • DOI

      10.1351/pac-con-11-12-10

    • Related Report
      2012 Research-status Report
    • Peer Reviewed
  • [Journal Article] Pig sperm membrane microdomains contain a highly glycosylated 15–25-kDa wheat germ agglutinin-binding protein.2012

    • Author(s)
      Waraporn Kasekarn, Takeru Kanazawa, Kazuki Hori, Tomoyuki, Tsuchiyama, Xue Lian, Estelle Garénaux, Kessiri Kongmanas, Nongnuj Tanphaichitr, Hiroshi Yasue, Chihiro Sato and Ken Kitajima
    • Journal Title

      Biochem. Biophys. Res. Commun.

      Volume: 426 Pages: 356-362

    • Related Report
      2012 Research-status Report
    • Peer Reviewed
  • [Journal Article] Metabolism of vertebrate amino sugars with N-glycolyl groups: Resistance of α2-8-linked N-glycolylneuraminic Acid to Enzymatic Cleavage.2012

    • Author(s)
      Davies, L.,Pearce, O., Tessier, M., Assar M., Smutova, V., Pajunen, M., Sumida, M., Sato, C., Kitajima, K., Finne, J., Gagneux,P., Pshezhetsky, A., Woods, R., and Varki A.
    • Journal Title

      J Biol Chem.

      Volume: 287 Issue: 34 Pages: 28917-28931

    • DOI

      10.1074/jbc.m112.365056

    • Related Report
      2012 Research-status Report
    • Peer Reviewed
  • [Journal Article] Sialome analysis of the cephalochordate Branchiostoma belcheri, a key organism for vertebrate evolution2012

    • Author(s)
      Guerardel, Yann
    • Journal Title

      Glycobiology

      Volume: 22 Issue: 4 Pages: 479-491

    • DOI

      10.1093/glycob/cwr155

    • Related Report
      2012 Research-status Report
    • Peer Reviewed
  • [Journal Article] Sialidase NEU4 Hydrolyzes Polysialic Acids of Neural Cell Adhesion Molecules and Negatively Regulates Neurite Formation by Hippocampal Neurons.2012

    • Author(s)
      Takahashi K、ほか7名
    • Journal Title

      J Biol Chem.

      Volume: 287 Issue: 18 Pages: 14816-14826

    • DOI

      10.1074/jbc.m111.324186

    • Related Report
      2012 Research-status Report
    • Peer Reviewed
  • [Journal Article] Structural and functional impairments of polysialic acid by a mutated polysialyltransferase found in schizophrenia2011

    • Author(s)
      Isomura R, Kitajima K, and Sato C.
    • Journal Title

      J. Biol. Chem.

      Volume: 286(24)

    • Related Report
      2013 Final Research Report
  • [Journal Article] Co-expression of two distinct polysialic acids,α2,8- andα2,9-linked polymers of N-acetylneuraminic acid, in distinct glycoproteins and glycolipids in sea urchin sperm2011

    • Author(s)
      Miyata S, Yamakawa N, Toritama M, Sato C, Kitajima K.
    • Journal Title

      Glycobiology

      Volume: 21(12) Pages: 1596-1605

    • Related Report
      2013 Final Research Report
  • [Journal Article] Human KDN (deaminated neuraminic acid) and its elevated expression in cancer cells : mechanism and significance2011

    • Author(s)
      Inoue S, Kitajima K, Sato C, Go S.
    • Journal Title

      Adv Exp Med Biol.

      Volume: 705 Pages: 669-678

    • Related Report
      2013 Final Research Report
  • [Journal Article] Mechanism regulating Ca2^+-dependent mechanosensory behaviour in sea urchin spermatozoa2011

    • Author(s)
      Kambara Y, Shiba K, Yoshida M, Sato C, Kitajima K, Shingyoji C.
    • Journal Title

      Cell Struct Funct.

      Volume: 36(1) Pages: 69-82

    • NAID

      130004137565

    • Related Report
      2013 Final Research Report
  • [Journal Article] Structural and functional impairments2011

    • Author(s)
      Isomura R, Kitajima K, and Sato C
    • Journal Title

      J. Biol. Chem.

      Volume: 286 Pages: 21535-21545

    • Related Report
      2011 Research-status Report
    • Peer Reviewed
  • [Journal Article] Co-expression of two distinct polysialic acids2011

    • Author(s)
      Miyata S, Yamakawa N, Toritama M, Sato C, et a
    • Journal Title

      Glycobiology

      Volume: 21 Pages: 1596-1605

    • Related Report
      2011 Research-status Report
    • Peer Reviewed
  • [Journal Article] Human KDN2011

    • Author(s)
      Inoue S, Kitajima K, Sato C, Go S
    • Journal Title

      Adv Exp Med Biol.

      Volume: 705 Pages: 669-678

    • Related Report
      2011 Research-status Report
    • Peer Reviewed
  • [Journal Article] Mechanism regulating Ca2+-dependent2011

    • Author(s)
      Kambara Y, Shiba K, Yoshida M, Sato C, et al
    • Journal Title

      Cell Struct Funct.

      Volume: 36 Pages: 69-82

    • Related Report
      2011 Research-status Report
    • Peer Reviewed
  • [Journal Article] New function of polysialic acid2011

    • Author(s)
      Sato C, Kitajima K
    • Journal Title

      Seikagaku

      Volume: 83 Pages: 189-196

    • Related Report
      2011 Research-status Report
    • Peer Reviewed
  • [Journal Article] New function of polysialic acid and its2011

    • Author(s)
      Sato C, Kitajima K.
    • Journal Title

      Trends Glycsci Glycotech

      Volume: 23 Pages: 221-238

    • Related Report
      2011 Research-status Report
    • Peer Reviewed
  • [Presentation] ポリシアル酸研究の新展開2014

    • Author(s)
      佐藤ちひろ
    • Organizer
      第三回コンビナトリアル科学研究推進体セミナー「糖鎖の構造と機能のシンポジウム」
    • Place of Presentation
      東京工業大学, 大岡山
    • Year and Date
      2014-03-11
    • Related Report
      2013 Final Research Report
    • Invited
  • [Presentation] 癌や精神疾患に関わるポリシアル酸構造に特異的な一本鎖抗体の作製と特異性評価.2014

    • Author(s)
      羽根正弥、長江雅倫、池田明美、山口芳樹、北島健、佐藤ちひろ.
    • Organizer
      日本農芸化学会2014年度東京大会
    • Place of Presentation
      明治大学生田キャンパス、神奈川
    • Related Report
      2013 Annual Research Report
  • [Presentation] Direct interaction of FGF2 with polysialic acid regulates the cell growth, but not cell survival2013

    • Author(s)
      Sayaka Ono, Masaya Hane, Ken Kitajima, Chihiro Sato.
    • Organizer
      22nd International Symposium on Glycoconjugates
    • Place of Presentation
      convention center of Dalian Institute of Chemical Physics, Dalian, China
    • Related Report
      2013 Final Research Report
  • [Presentation] Polysialic acid as an on-site regulator of biologically active molecules2013

    • Author(s)
      Chihiro Sato.
    • Organizer
      3rd Austria-Japan Seminar on Comparative and Developmental Glycobiology
    • Place of Presentation
      Riken, Wako, Japan
    • Related Report
      2013 Final Research Report
    • Invited
  • [Presentation] Direct interaction of FGF2 with polysialic acid regulates the cell growth, but not cell survival.2013

    • Author(s)
      Sayaka Ono**, Masaya Hane*, Ken Kitajima, Chihiro Sato.
    • Organizer
      22nd International Symposium on Glycoconjugates
    • Place of Presentation
      convention center of Dalian Institute of Chemical Physics, Dalian, China
    • Related Report
      2013 Annual Research Report
    • Invited
  • [Presentation] ポリシアル酸の新機能としての神経作用因子結合能に関する解析.2013

    • Author(s)
      佐藤ちひろ、羽根正弥、西村紗希、松岡修平、金戸幸弘、磯村遼、小野明香、北島健.
    • Organizer
      第32回日本糖質学会年会
    • Place of Presentation
      大阪国際交流センター、大阪
    • Related Report
      2013 Annual Research Report
  • [Presentation] Polysialic acid as an on-site regulator of biologically active molecules.2013

    • Author(s)
      Chihiro Sato
    • Organizer
      3rd Austria-Japan Seminar on Comparative and Developmental Glycobiology
    • Place of Presentation
      Riken, Wako, Japan
    • Related Report
      2013 Annual Research Report
    • Invited
  • [Presentation] Ubiquitous occurrence and biosynthesis of sulfated sialic acids in mammals.2013

    • Author(s)
      Thanyaluck Phitak, Hiroshi Fujita, Chihiro Sato, Ken Kitajima.
    • Organizer
      22nd International Symposium on Glycoconjugates
    • Place of Presentation
      convention center of Dalian Institute of Chemical Physics, Dalian, China
    • Related Report
      2013 Annual Research Report
  • [Presentation] Analysis of polySia-NCAM biosynthesized by a mutated polysialyltransferase ST8SIA2/STX found in a schizophrenic patient.2013

    • Author(s)
      Masaya Hane, Ken Kitajima, Chihiro Sato.
    • Organizer
      22nd International Symposium on Glycoconjugates
    • Place of Presentation
      convention center of Dalian Institute of Chemical Physics, Dalian, China
    • Related Report
      2013 Annual Research Report
  • [Presentation] The insect CMP-sialic acid synthetases: New features in the enzyme activity and intracellular localization.2013

    • Author(s)
      Di Wu, Akiko Fujita, Kayo Hamaguchi, Anne Harduin-Lepers, Philippe Delannoy, Vladislav M. Panin, Chihiro Sato, Ken Kitajima.
    • Organizer
      22nd International Symposium on Glycoconjugates
    • Place of Presentation
      convention center of Dalian Institute of Chemical Physics, Dalian, China
    • Related Report
      2013 Annual Research Report
  • [Presentation] Crystal structure of an anti-polysialic acid antibody single chain Fv fragment in complex with α2-8-linked oligo sialic acid.2013

    • Author(s)
      Masamichi Nagae, Akemi Ikeda, Shinya Hanashima, Ken Kitajima, Chihiro Sato, Yoshiki Yamaguchi.
    • Organizer
      22nd International Symposium on Glycoconjugates
    • Place of Presentation
      convention center of Dalian Institute of Chemical Physics, Dalian, China
    • Related Report
      2013 Annual Research Report
  • [Presentation] ブタ精漿タンパク質WGA16の精子表面への結合と解離はその糖鎖とレクチン活性が制御する2013

    • Author(s)
      ガレノ・エステル, 金川真由美, 金澤尊, 堀和紀, 安江博, 池田明美, 山口芳樹, 佐藤ちひろ, 北島健.
    • Organizer
      第32回日本糖質学会年会;
    • Place of Presentation
      大阪国際交流センター、大阪
    • Related Report
      2013 Annual Research Report
  • [Presentation] FGF2依存的細胞増殖におけるポリシアル酸およびヘパラン硫酸の効果.2013

    • Author(s)
      羽根正弥, 小野明香, 北島健, 佐藤ちひろ.
    • Organizer
      第32回日本糖質学会年会;
    • Place of Presentation
      大阪国際交流センター、大阪
    • Related Report
      2013 Annual Research Report
  • [Presentation] The study on gene structure and intracellular localization of the insect CMP-sialic acid synthetases.2013

    • Author(s)
      Di Wu, Akiko Fujita, Kayo Hamaguchi, Anne Harduin-Lepers, Philippe Delannoy, Vladislav M. Panin, Chihiro Sato, Ken Kitajima.
    • Organizer
      第32回日本糖質学会年会;
    • Place of Presentation
      大阪国際交流センター、大阪
    • Related Report
      2013 Annual Research Report
  • [Presentation] メダカ初期発生においてα2,6-結合シアル酸残基の発現は必須である.2013

    • Author(s)
      田嶋克枝, 丸山恵美, Chang Lan-Yi, 足立朋子, 橋本寿史, 日比正彦, 佐藤ちひろ, 北島健.
    • Organizer
      第32回日本糖質学会年会
    • Place of Presentation
      大阪国際交流センター、大阪
    • Related Report
      2013 Annual Research Report
  • [Presentation] 昆虫由来シアル酸アルドラーゼSPLの存在と性質.2013

    • Author(s)
      藤田明子、熊澤慎介、小林隆史、門脇辰彦、佐藤ちひろ、北島健.
    • Organizer
      第32回日本糖質学会年会
    • Place of Presentation
      大阪国際交流センター、大阪
    • Related Report
      2013 Annual Research Report
  • [Presentation] ポリシアル酸はFGF-2の構造依存的に結合し、その寿命を制御する働きを持つ.2013

    • Author(s)
      松岡修平, 羽根正弥, 西村紗希,北島健, 佐藤ちひろ.
    • Organizer
      第32回日本糖質学会年会
    • Place of Presentation
      大阪国際交流センター、大阪
    • Related Report
      2013 Annual Research Report
  • [Presentation] 糖タンパク質の等電点を指標とした、肝再生過程における翻訳後修飾の変動解析.2013

    • Author(s)
      作田香子, 曽布川尚美, 佐藤ちひろ, 北島健, 佐野琴音, 小川温子.
    • Organizer
      第32回日本糖質学会年会
    • Place of Presentation
      大阪国際交流センター、大阪
    • Related Report
      2013 Annual Research Report
  • [Presentation] ガングリオシド糖鎖ライブラリーを用いたSiglec-7のGD3結合制御メカニズムの解析.2013

    • Author(s)
      安田優, 田中浩士, 高橋孝志, Paul Crocker, 北島健, 佐藤ちひろ.
    • Organizer
      第86回日本生化学会大会
    • Place of Presentation
      パシフィコ横浜
    • Related Report
      2013 Annual Research Report
  • [Presentation] FGF2依存的細胞増殖に対するポリシアル酸とヘパラン硫酸の異なる効果2013

    • Author(s)
      羽根正弥, 小野明香, 北島健, 佐藤ちひろ
    • Organizer
      第86回日本生化学会大会
    • Place of Presentation
      パシフィコ横浜
    • Related Report
      2013 Annual Research Report
  • [Presentation] The first comparative study of enzyme properties of the insect CMP-sialic acid synthetases.2013

    • Author(s)
      Di Wu, Fujita A, Hamaguchi K, Harduin-Lepers A, Delannoy P, Panin VM, Sato C, Kitajima K.
    • Organizer
      第86回日本生化学会大会
    • Place of Presentation
      パシフィコ横浜
    • Related Report
      2013 Annual Research Report
  • [Presentation] 細胞内シアル酸種の微量分別定量法の確立.2013

    • Author(s)
      川本英里, 佐藤ちひろ, 北島健.
    • Organizer
      第86回日本生化学会大会
    • Place of Presentation
      パシフィコ横浜
    • Related Report
      2013 Annual Research Report
  • [Presentation] IMR32細胞におけるポリシアル酸発現に対する統合失調症薬の効果2013

    • Author(s)
      西村紗希, 北島健, 佐藤ちひろ.
    • Organizer
      第86回日本生化学会大会
    • Place of Presentation
      パシフィコ横浜
    • Related Report
      2013 Annual Research Report
  • [Presentation] メダカ初期胚表面α2,6-結合シアル酸残基は発生過程に必要である2013

    • Author(s)
      田嶋克枝, 丸山恵美, Chang Lan-Yi, 足立朋子, 橋本寿史, 日比正彦, 佐藤ちひろ, 北島健
    • Organizer
      日本動物学会第84回岡山大会
    • Place of Presentation
      岡山大学津島キャンパス・岡山
    • Related Report
      2013 Annual Research Report
  • [Presentation] 統合失調症患者に見出されたST8SiaII/STXが生合成するポリシアル酸の構造解析2013

    • Author(s)
      羽根 正弥、北島 健、佐藤 ちひろ
    • Organizer
      日本農芸化学会2013年度仙台大会
    • Place of Presentation
      仙台、日本
    • Related Report
      2012 Research-status Report
  • [Presentation] Characterization and intracellular localization of the insect CMP-sialic acid syntheses2013

    • Author(s)
      呉 迪, 藤田明子, 濵口香代, Anne Harduin-Lepers, Philippe Delannoy, Vladislav M. Panin, 佐藤ちひろ, 北島 健
    • Organizer
      日本農芸化学会2013年度仙台大会
    • Place of Presentation
      仙台、日本
    • Related Report
      2012 Research-status Report
  • [Presentation] A polysialyltransferase SNP in a schizophrenic patient brings about the production of polysialic acids showing impaired binding and signaling of BDNF and FGF22012

    • Author(s)
      Ken Kitajima, Chihiro Sato.
    • Organizer
      8th International Symposium on Glycosyltransferases
    • Place of Presentation
      Hannover, Germany
    • Related Report
      2013 Final Research Report
    • Invited
  • [Presentation] Novel regulation of neurological active molecules by polysialic acids2012

    • Author(s)
      Chihiro Sato.
    • Organizer
      SialoGlyco 2012
    • Place of Presentation
      Academia Sinica, Taipei, Taiwan
    • Related Report
      2013 Final Research Report
    • Invited
  • [Presentation] A polysialyltransferase SNP in a schizophrenic patient brings about the production of polysialic acids showing impaired binding and signaling of BDNF and FGF2.2012

    • Author(s)
      Ken Kitajima, Chihiro Sato
    • Organizer
      8th International Symposium on Glycosyltransferases
    • Place of Presentation
      Hannover, Germany
    • Related Report
      2012 Research-status Report
    • Invited
  • [Presentation] Novel regulation of neurological active molecules by polysialic acids.2012

    • Author(s)
      Chihiro Sato
    • Organizer
      SialoGlyco 2012
    • Place of Presentation
      Taipei, Taiwan
    • Related Report
      2012 Research-status Report
    • Invited
  • [Presentation] Structural and functional impairments of polysialic acid on the neural cell adhesion molecule (NCAM) synthesized by a mutated polysialyltransferase of a schizophrenic patient.2012

    • Author(s)
      Masaya Hane, Mizuki Sumida, Ken Kitajima, Chihiro Sato.
    • Organizer
      SialoGlyco 2012
    • Place of Presentation
      Taipei, Taiwan
    • Related Report
      2012 Research-status Report
  • [Presentation] Regulation of the intracellular Ca2+ by a highly glycosylated protein on sperm microdomains.2012

    • Author(s)
      Takeru Kanazawa, Waraporn Kasekarn, Estelle Garenaux, Hiroshi Yasue, Chihiro Sato, and Ken Kitajima.
    • Organizer
      ACGG 2012 Conference
    • Place of Presentation
      Jeju Island, Korea
    • Related Report
      2012 Research-status Report
  • [Presentation] 記憶や行動に関わるpolySia-NCAMの新機能2012

    • Author(s)
      佐藤ちひろ、金戸幸広、磯村遼、小野明日香、羽根正弥、西村沙希、松岡修平、北島健
    • Organizer
      2012年度 包括型脳科学研究推進支援ネットワーク 夏のワークショップ
    • Place of Presentation
      仙台, 日本
    • Related Report
      2012 Research-status Report
  • [Presentation] ブタ精子ラフト局在糖タンパク質WGA-gpの構造とCaイオン調節機能2012

    • Author(s)
      金澤尊*、Estelle Garénaux、Waraporn Kasekarn、堀和紀**、安江博、佐藤ちひろ、北島健
    • Organizer
      日本動物学会第83回大阪大会
    • Place of Presentation
      大阪、日本
    • Related Report
      2012 Research-status Report
  • [Presentation] 細胞表面α2,6-結合シアル酸残基はメダカ初期発生の進行に必要である2012

    • Author(s)
      丸山恵美, 田嶋克枝, Chang Lan-Yi, 足立朋子, 橋本寿史, 日比正彦, 佐藤ちひろ, 北島健
    • Organizer
      日本動物学会第83回大阪大会
    • Place of Presentation
      大阪、日本
    • Related Report
      2012 Research-status Report
  • [Presentation] ウニ精子の機械刺激時のCa2+依存性鞭毛運動制御に対する脂質ラフト形成阻害剤等の効果.2012

    • Author(s)
      中野泉、蒲原祐花、金澤尊*、佐藤ちひろ、北島健、真行寺千佳子
    • Organizer
      日本動物学会第83回大阪大会
    • Place of Presentation
      大阪、日本
    • Related Report
      2012 Research-status Report
  • [Presentation] 動物精子のマイクロドメインに存在する高度糖鎖修飾糖タンパク質の構造と機能.2012

    • Author(s)
      金澤尊、Estelle Garénaux、Waraporn Kasekarn、堀和紀、安江博、佐藤ちひろ、北島健
    • Organizer
      第31回日本糖質学会年会
    • Place of Presentation
      鹿児島,日本
    • Related Report
      2012 Research-status Report
  • [Presentation] 統合失調症患者に見いだされたST8SiaII/STX遺伝子変異SNP-7が生合成するpolySia-NCAMの特徴2012

    • Author(s)
      羽根正弥、住田瑞季、北島健、佐藤ちひろ
    • Organizer
      第31回日本糖質学会年会
    • Place of Presentation
      鹿児島,日本
    • Related Report
      2012 Research-status Report
  • [Presentation] Glycan-modulated binding of the prostate-derived seminal plasma protein WGA16 to the sperm surface2012

    • Author(s)
      Estelle Garenaux, Takeru Kanazawa, Kazuki Hori, Hiroshi Yasue, Chihiro Sato, Ken Kitajima.
    • Organizer
      第31回日本糖質学会年会
    • Place of Presentation
      鹿児島,日本
    • Related Report
      2012 Research-status Report
  • [Presentation] ガングリオシド糖鎖ライブラリーを用いたSiglec-7のGD3結合阻害様式の解析2012

    • Author(s)
      安田優、西浦祐二、田中浩士、高橋孝志、Paul Crocker, 北島健、佐藤ちひろ
    • Organizer
      第31回日本糖質学会年会
    • Place of Presentation
      鹿児島,日本
    • Related Report
      2012 Research-status Report
  • [Presentation] Serum content of sialic acid and its alterations with age and Alzheimer pathogenesis.2012

    • Author(s)
      Phitak Thanyaluck, Chihiro Sato, Kenji Uchimura, Ken Kitajima.
    • Organizer
      第31回日本糖質学会年会
    • Place of Presentation
      鹿児島,日本
    • Related Report
      2012 Research-status Report
  • [Presentation] Enzymatic properties of the insect CMP-sialic acid synthetases.2012

    • Author(s)
      Di Wu*, Akiko Fujita**, Kayo Hamaguchi**, Anne Harduin-Lepers, Philippe Delannoy, Vladislav M. Panin, Chihiro Sato, Ken Kitajima
    • Organizer
      第31回日本糖質学会年会
    • Place of Presentation
      鹿児島,日本
    • Related Report
      2012 Research-status Report
  • [Presentation] NMRを用いたオリゴシアル酸と抗体の相互作用解析2012

    • Author(s)
      花島慎弥、佐藤ちひろ、田中浩士、高橋孝志、北島健、山口芳樹
    • Organizer
      第31回日本糖質学会年会
    • Place of Presentation
      鹿児島,日本
    • Related Report
      2012 Research-status Report
  • [Presentation] Sperm surface binding of the prostate-derived seminal plasma protein WGA16 is modulated by glycosaminoglycans.2012

    • Author(s)
      Estelle Garenaux, Takeru Kanazawa, Kazuki Hori, Hiroshi Yasue, Chia-Wei Lin, Kay-Hooi Khoo, Chihiro Sato, Ken Kitajima
    • Organizer
      第85回日本生化学会大会
    • Place of Presentation
      福岡、日本
    • Related Report
      2012 Research-status Report
  • [Presentation] Molecular characterization of a novel sulfotransferase from gonad of sea urchin, Hemicentrotus pulcherrimus.2012

    • Author(s)
      Phitak Thanyaluck, Chihiro Sato, Ken Kitajima.
    • Organizer
      第85回日本生化学会大会;
    • Place of Presentation
      福岡、日本
    • Related Report
      2012 Research-status Report
  • [Presentation] 統合失調症患者由来ST8SiaII/STXによって生合成するpolySia構造の質と量の解析2012

    • Author(s)
      羽根正弥、住田瑞季、北島健、佐藤ちひろ
    • Organizer
      第85回日本生化学会大会
    • Place of Presentation
      福岡、日本
    • Related Report
      2012 Research-status Report
  • [Presentation] Enzyme activity and intracellular localization of the insect CMP-sialic acid synthetases.2012

    • Author(s)
      呉 迪, 藤田明子, 濵口香代, Anne Harduin-Lepers, Philippe Delannoy, Vladislav M. Panin, 佐藤ちひろ, 北島 健
    • Organizer
      第85回日本生化学会大会
    • Place of Presentation
      福岡、日本
    • Related Report
      2012 Research-status Report
  • [Presentation] ウニ配偶子におけるポリシアル酸構造と生合成酵素の多様性.2012

    • Author(s)
      萩原尚文, 鳥山優, 佐藤ちひろ, 北島健
    • Organizer
      第85回日本生化学会大会
    • Place of Presentation
      福岡、日本
    • Related Report
      2012 Research-status Report
  • [Presentation] ガングリオシド糖鎖ライブラリーを用いて解明されたSiglec-7の新たなリガンド結合性2012

    • Author(s)
      安田優, 田中浩士, 高橋孝志, Paul Crocker, 北島健, 佐藤ちひろ
    • Organizer
      第85回日本生化学会大会
    • Place of Presentation
      福岡、日本
    • Related Report
      2012 Research-status Report
  • [Presentation] シアル酸種の細胞特異的選択におけるCMP-シアル酸トランスポーターの役割2012

    • Author(s)
      川本英里, 佐藤ちひろ, 北島健
    • Organizer
      第85回日本生化学会大会
    • Place of Presentation
      福岡、日本
    • Related Report
      2012 Research-status Report
  • [Presentation] ブタ胎児脳および成体脳におけるポリシアリル化NCAM構造の質と量の解析2012

    • Author(s)
      西村紗希, 北島健, 佐藤ちひろ
    • Organizer
      第85回日本生化学会大会
    • Place of Presentation
      福岡、日本
    • Related Report
      2012 Research-status Report
  • [Presentation] ヒト癌組織でのシアル酸付加された複合型のN型遊離糖鎖の蓄積:KDN付加された遊離糖鎖の前立腺癌での特異的な蓄積2012

    • Author(s)
      藪政彦, 是金宏昭, 佐藤ちひろ, 北島健, 宮本泰豪
    • Organizer
      第85回日本生化学会大会
    • Place of Presentation
      福岡、日本
    • Related Report
      2012 Research-status Report
  • [Presentation] Polysialic acid as a regulator2012

    • Author(s)
      Ken Kitajima and Chihiro Sato.
    • Organizer
      GCOE International Symposium(招待講演)
    • Place of Presentation
      Sakata & Hirata Hall, Nagoya University, Japan
    • Related Report
      2011 Research-status Report
  • [Presentation] Glycomics profiling of Zebrafish2012

    • Author(s)
      Yamakawa, (2人), Sato, Kitajima, Gurrardel.
    • Organizer
      GCOE International Symposium
    • Place of Presentation
      Sakata & Hirata Hall, Nagoya University, Japan
    • Related Report
      2011 Research-status Report
  • [Presentation] Expression of sialic acids2012

    • Author(s)
      Akiko Fujita,(3人), Chihiro Sato, Ken Kitajima.
    • Organizer
      GCOE International Symposium
    • Place of Presentation
      Sakata & Hirata Hall, Nagoya University, Japan
    • Related Report
      2011 Research-status Report
  • [Presentation] In vivo tracking glycosylation2012

    • Author(s)
      Chang,(2人),Sato, Kitajima, Guerardel.
    • Organizer
      GCOE International Symposium
    • Place of Presentation
      Sakata & Hirata Hall, Nagoya University, Japan
    • Related Report
      2011 Research-status Report
  • [Presentation] 昆虫細胞におけるシアル酸代謝の特徴について2012

    • Author(s)
      北島健、藤田明子、小林隆史、呉迪、Garenaux Estelle、濵口香代、郷慎司、佐藤ちひろ
    • Organizer
      日本農芸化学会2012年度京都大会
    • Place of Presentation
      京都女子大学、京都
    • Related Report
      2011 Research-status Report
  • [Presentation] ブタ精子におけるマイクロドメイン局在性糖タンパク質WGA-gpの生理機能2012

    • Author(s)
      金沢尊、(4人)、佐藤ちひろ、北島健
    • Organizer
      日本農芸化学会2012年度京都大会
    • Place of Presentation
      京都女子大学、京都
    • Related Report
      2011 Research-status Report
  • [Presentation] 統合失調症患者に見出された一塩基多型(SNP-7)由来のポリシアル酸転移酵素2012

    • Author(s)
      羽根正弥、磯村遼、北島健、佐藤ちひろ
    • Organizer
      日本農芸化学会2012年度京都大会
    • Place of Presentation
      京都女子大学、京都
    • Related Report
      2011 Research-status Report
  • [Presentation] Polysialic acid chains display attractive fields toward neuroactive molecules2011

    • Author(s)
      Sayaka Ono, Ryo Isomura, Masaya Hane, Mizuki Sumida, Ken Kitajima, Chihiro Sato.
    • Organizer
      The 21st International Symposium on Glycoconjugates
    • Place of Presentation
      The University of Vienna, Vienna, Austria (選抜講演)
    • Related Report
      2013 Final Research Report
  • [Presentation] Polysialic acid chains display2011

    • Author(s)
      Ono, Isomura, Hane, Sumida, Kitajima, Sato.
    • Organizer
      International Symposium on Glycoconjugates
    • Place of Presentation
      The University of Vienna, Vienna, Austria
    • Related Report
      2011 Research-status Report
  • [Presentation] Discovery, characterization and2011

    • Author(s)
      Kanazawa, (4人), Sato, Kitajima.
    • Organizer
      3rd Biochemstry and Molecular Biology Conference(招待講演)
    • Place of Presentation
      Chiang Mai, Thailand
    • Related Report
      2011 Research-status Report
  • [Presentation] Metabolism of sialic acid (Sia) in protochordates2011

    • Author(s)
      Fujita, Sato, (4人), Ken Kitajima.
    • Organizer
      International Symposium on Glycoconjugates
    • Place of Presentation
      The University of Vienna, Vienna, Austria
    • Related Report
      2011 Research-status Report
  • [Presentation] Novel regulation of neuroactive molecules2011

    • Author(s)
      Ken Kitajima, Chihiro Sato.
    • Organizer
      Glycobiology Japan-Netherland Joint Seminar 2011(招待講演)
    • Place of Presentation
      Nagoya University, Japan
    • Related Report
      2011 Research-status Report
  • [Presentation] Neuroactive molecule-retaining functions2011

    • Author(s)
      Ken Kitajima and Chihiro Sato.
    • Organizer
      Gordon Research Conference on Glycobiology 2011
    • Place of Presentation
      Il Ciocco Hotel and Resort, Barga, Italy.
    • Related Report
      2011 Research-status Report
  • [Presentation] Sialic acid metabolism in insect2011

    • Author(s)
      Fujita, Kobayashi, Sato, Kitajima.
    • Organizer
      Gordon Research Conference on Glycobiology 2011
    • Place of Presentation
      Il Ciocco Hotel and Resort, Barga, Italy.
    • Related Report
      2011 Research-status Report
  • [Presentation] The highly glycosylated seminal plasma2011

    • Author(s)
      Kanazawa, (2人),Sato,Kitajima.
    • Organizer
      International Symposium on Glycoconjugates
    • Place of Presentation
      The University of Vienna, Vienna, Austria
    • Related Report
      2011 Research-status Report
  • [Presentation] Isolation and characterization of a2011

    • Author(s)
      Kanazawa, (5人) Sato, Kitajima.
    • Organizer
      International Symposium on Glycoconjugates;
    • Place of Presentation
      The University of Vienna, Vienna, Austria.
    • Related Report
      2011 Research-status Report
  • [Presentation] Extensive incorporation2011

    • Author(s)
      Sadako Inoue, Chihiro Sato, and Ken Kitajima.
    • Organizer
      International Symposium on Glycoconjugates
    • Place of Presentation
      The University of Vienna, Vienna, Austria.
    • Related Report
      2011 Research-status Report
  • [Presentation] In vivo tracking glycosylation2011

    • Author(s)
      Chang, (2人), Sato, Kitajima, Guerardel
    • Organizer
      The 5th Asia-Oceania Zebrafish Meeting;
    • Place of Presentation
      Beijing, China.
    • Related Report
      2011 Research-status Report
  • [Presentation] In vivo tracking glycosylation2011

    • Author(s)
      Chang, (2人), Sato, Kitajima, Guerardel
    • Organizer
      The 71st Okazaki Conference
    • Place of Presentation
      National Institute of Natural Sciences, Japan
    • Related Report
      2011 Research-status Report
  • [Presentation] NMR binding analyses2011

    • Author(s)
      Hanashima, Sato, (4人)
    • Organizer
      The 71st Okazaki Conference
    • Place of Presentation
      National Institute of Natural Sciences, Japan
    • Related Report
      2011 Research-status Report
  • [Presentation] In vivo tracking glycosylation2011

    • Author(s)
      Chang, (2人), Sato, Kitajima, Guerardel
    • Organizer
      The 31st Naito Conference
    • Place of Presentation
      Gateaux Kingdom Sapporo, Sapporo, Japan.
    • Related Report
      2011 Research-status Report
  • [Presentation] Specific interaction of the highly2011

    • Author(s)
      Garenaux, Hori, Sato, Kitajima.
    • Organizer
      The 31st Naito Conference
    • Place of Presentation
      ateaux Kingdom Sapporo, Sapporo, Japan.
    • Related Report
      2011 Research-status Report
  • [Presentation] Isolation and characterization2011

    • Author(s)
      Kanazawa,(4人), Sato, Kitajima.
    • Organizer
      The 31st Naito Conference
    • Place of Presentation
      Gateaux Kingdom Sapporo, Sapporo, Japan.
    • Related Report
      2011 Research-status Report
  • [Presentation] Systematic glycan profiling2011

    • Author(s)
      Yamakawa,Vanbeselaere,Sato,(2人)
    • Organizer
      22nd Joint Glycobiology Meteing
    • Place of Presentation
      University of Lille 1, Lille, France
    • Related Report
      2011 Research-status Report
  • [Presentation] ウニ初期胚マイクロドメインに局在する糖鎖エピトープの構造と機能2011

    • Author(s)
      萩原尚文、中村奈央子、前橋絵梨、山川奈緒、佐藤ちひろ、鳥山優、北島健
    • Organizer
      第75回日本生化学中部支部例会・シンポジウム
    • Place of Presentation
      静岡県立大学・静岡
    • Related Report
      2011 Research-status Report
  • [Presentation] 脳に局在する酸性多糖ポリシアル酸とFGF2の相互作用解析2011

    • Author(s)
      羽根正弥、小野明香、住田瑞季、北島健、佐藤ちひろ
    • Organizer
      第75回日本生化学中部支部例会・シンポジウム
    • Place of Presentation
      静岡県立大学・静岡
    • Related Report
      2011 Research-status Report
  • [Presentation] ブタ精子ラフト糖タンパク質WGA-gpの精子活性化における役割.2011

    • Author(s)
      金澤尊、Waraporn Kasekarn、堀和紀、土山智之、安江博、佐藤ちひろ、北島健.
    • Organizer
      日本動物学会第82回旭川大会
    • Place of Presentation
      旭川市大雪クリスタルホール・旭川
    • Related Report
      2011 Research-status Report
  • [Presentation] メダカ初期発生におけるシアロ糖鎖の重要性の検証.2011

    • Author(s)
      丸山恵実、足立朋子、橋本寿史、日比正彦、佐藤ちひろ、北島健.
    • Organizer
      日本動物学会第82回旭川大会;
    • Place of Presentation
      旭川市大雪クリスタルホール・旭川
    • Related Report
      2011 Research-status Report
  • [Presentation] ウニ初期胚マイクロドメインに局在する糖鎖抗原の構造と機能2011

    • Author(s)
      萩原尚文、中村奈央子、Estelle Garénaux、佐藤ちひろ、鳥山優、北島健
    • Organizer
      日本動物学会第82回旭川大会
    • Place of Presentation
      旭川市大雪クリスタルホール・旭川
    • Related Report
      2011 Research-status Report
  • [Presentation] ウニ精子の機械受容反応に関与するカルシウム依存性膜タンパク質の活性制御.2011

    • Author(s)
      中野泉、蒲原祐花、佐藤ちひろ、北島健、真行寺千佳子
    • Organizer
      日本動物学会第82回旭川大会;
    • Place of Presentation
      旭川市大雪クリスタルホール・旭川
    • Related Report
      2011 Research-status Report
  • [Presentation] ブタ精子膜マイクロドメインに局在する糖タンパク質WGA-gpの生理機能.2011

    • Author(s)
      金澤尊、(4人)、佐藤ちひろ、北島健
    • Organizer
      糖鎖科学名古屋拠点「若手の力」フォーラム第9回
    • Place of Presentation
      岐阜
    • Related Report
      2011 Research-status Report
  • [Presentation] 哺乳類de novoシアル酸合成におけるシアル酸ピルビン酸リアーゼの関与2011

    • Author(s)
      小林隆史、佐藤ちひろ、北島健
    • Organizer
      糖鎖科学名古屋拠点「若手の力」フォーラム第9回
    • Place of Presentation
      岐阜
    • Related Report
      2011 Research-status Report
  • [Presentation] メダカ胚シアロ糖鎖の受精・初期発生における役割の解析2011

    • Author(s)
      丸山恵実、佐藤ちひろ、足立朋子、井上慎子、橋本寿史、日比正彦、北島健
    • Organizer
      糖鎖科学名古屋拠点「若手の力」フォーラム第9回
    • Place of Presentation
      岐阜
    • Related Report
      2011 Research-status Report
  • [Presentation] NMRを用いたa(2,8)オリゴシアル酸と抗体との相互作用解析2011

    • Author(s)
      花島慎弥、佐藤ちひろ、田中浩士、高橋孝志、北島健、山口芳樹
    • Organizer
      GlycoTokyo 2011シンポジウム
    • Place of Presentation
      理化学研究所, 埼玉
    • Related Report
      2011 Research-status Report
  • [Presentation] ポリシアル酸の新機能としての神経作用因子結合能に関する解析

    • Author(s)
      佐藤ちひろ
    • Organizer
      日本糖質学会第32回日本糖質学会年会
    • Place of Presentation
      大阪国際交流センター, 大阪 (選抜講演)
    • Related Report
      2013 Final Research Report
  • [Presentation] ポリシアル酸研究の新展開

    • Author(s)
      佐藤ちひろ
    • Organizer
      第三回コンビナトリアル科学研究推進体セミナー「糖鎖の構造と機能のシンポジウム」
    • Place of Presentation
      東京工業大学、大岡山
    • Related Report
      2013 Annual Research Report
    • Invited
  • [Presentation] セイヨウミツバチ由来シアル酸代謝酵素SPLの構造と性質

    • Author(s)
      藤田明子, 熊澤慎介, 小林隆史, 門脇辰彦, 佐藤ちひろ, 北島健
    • Organizer
      第77回日本生化学中部支部例会・シンポジウム
    • Place of Presentation
      名古屋大学, 坂田平田ホール, 名古屋
    • Related Report
      2013 Annual Research Report
  • [Presentation] ポリシアル酸はFGF-2の寿命を制御する働きを持つ.

    • Author(s)
      松岡修平, 羽根正弥, 西村紗希, 北島健, 佐藤ちひろ.
    • Organizer
      第77回日本生化学中部支部例会・シンポジウム
    • Place of Presentation
      名古屋大学, 坂田平田ホール, 名古屋
    • Related Report
      2013 Annual Research Report
  • [Presentation] 免疫組織染色を利用したN-グリコリルノイラミン酸のラット脳内分布の解析.

    • Author(s)
      松田夕妃乃, 南彰, 田口理紗, 中島さや香, 佐藤ちひろ, 北島健, 金澤寛明, 鈴木隆.
    • Organizer
      第77回日本生化学中部支部例会・シンポジウム
    • Place of Presentation
      名古屋大学, 坂田平田ホール, 名古屋
    • Related Report
      2013 Annual Research Report
  • [Presentation] N-グリコリルノイラミン酸がシナプス伝達効率の長期増強に与える影響の解析

    • Author(s)
      田口理紗, 南彰, 堀井雄樹, 石橋さやか, 佐藤ちひろ, 北島健, 池田潔, 鈴木隆
    • Organizer
      第77回日本生化学中部支部例会・シンポジウム
    • Place of Presentation
      名古屋大学, 坂田平田ホール, 名古屋
    • Related Report
      2013 Annual Research Report
  • [Presentation] Unique properties of the insect CMP-sialic acid synthetase.

    • Author(s)
      Di Wu, Sato C, Kitajima K.
    • Organizer
      平成25年度比較グライコーム研究会
    • Place of Presentation
      名古屋市立大学薬学部;研究棟会議室
    • Related Report
      2013 Annual Research Report
  • [Presentation] FGF2依存的細胞増殖に対するポリシアル酸とヘパラン硫酸の効果.

    • Author(s)
      羽根正弥, 小野明香, 北島健, 佐藤ちひろ
    • Organizer
      第11回糖鎖科学名古屋拠点「若手の力」フォーラム
    • Place of Presentation
      名古屋市立大学薬学部,名古屋
    • Related Report
      2013 Annual Research Report
  • [Presentation] Comparative study of enzyme properties of the insect CMP-sialic acid synthetases.

    • Author(s)
      Di Wu, Fujita A, Hamaguchi K, Harduin-Lepers A, Delannoy P, Panin VM, Sato C, Kitajima K.
    • Organizer
      第11回糖鎖科学名古屋拠点「若手の力」フォーラム
    • Place of Presentation
      名古屋市立大学薬学部,名古屋
    • Related Report
      2013 Annual Research Report
  • [Presentation] 細胞内シアル酸種の微量分別定量法.

    • Author(s)
      川本英里, 佐藤ちひろ, 北島健.
    • Organizer
      第11回糖鎖科学名古屋拠点「若手の力」フォーラム
    • Place of Presentation
      名古屋市立大学薬学部,名古屋
    • Related Report
      2013 Annual Research Report
  • [Presentation] 神経芽細胞腫細胞におけるポリシアル酸発現に対する統合失調症薬の効果

    • Author(s)
      西村紗希, 北島健, 佐藤ちひろ.
    • Organizer
      第11回糖鎖科学名古屋拠点「若手の力」フォーラム
    • Place of Presentation
      名古屋市立大学薬学部,名古屋
    • Related Report
      2013 Annual Research Report
  • [Presentation] メダカ初期胚表面シアル酸残基は発生過程に必要である.

    • Author(s)
      田嶋克枝, 丸山恵美, Chang Lan-Yi, 足立朋子, 橋本寿史, 日比正彦, 佐藤ちひろ, 北島健.
    • Organizer
      第11回糖鎖科学名古屋拠点「若手の力」フォーラム
    • Place of Presentation
      名古屋市立大学薬学部,名古屋
    • Related Report
      2013 Annual Research Report
  • [Presentation] 昆虫由来シアル酸アルドラーゼSPLの性質.

    • Author(s)
      熊澤慎介, 藤田明子, 小林隆史, 門脇辰彦, 佐藤ちひろ, 北島健
    • Organizer
      第11回糖鎖科学名古屋拠点「若手の力」フォーラム
    • Place of Presentation
      名古屋市立大学薬学部,名古屋
    • Related Report
      2013 Annual Research Report
  • [Presentation] ポリシアル酸はFGF-2の構造依存的に結合し、その寿命を制御する.

    • Author(s)
      松岡修平, 羽根正弥, 西村紗希, 北島健, 佐藤ちひろ
    • Organizer
      第11回糖鎖科学名古屋拠点「若手の力」フォーラム
    • Place of Presentation
      名古屋市立大学薬学部,名古屋
    • Related Report
      2013 Annual Research Report
  • [Presentation] ポリシアル酸とヘパラン硫酸はFGF2依存的細胞増殖に対して異なる効果をもつ

    • Author(s)
      羽根正弥、小野明香、北島健、佐藤ちひろ
    • Organizer
      第76回日本生化学中部支部例会・シンポジウム
    • Place of Presentation
      静岡、日本
    • Related Report
      2012 Research-status Report
  • [Presentation] Characterization of CMP-sialic acid synthetases from vertebrates and invertebrates.

    • Author(s)
      Wu Di, Fujita Akiko, Yasukawa Yuko, Sato Chihiro, Kitajima Ken
    • Organizer
      第76回日本生化学中部支部例会・シンポジウム
    • Place of Presentation
      静岡、日本
    • Related Report
      2012 Research-status Report
  • [Presentation] 統合失調症患者に見いだされたST8SiaII/STX遺伝子変異とpolySia-NCAMの構造と機能

    • Author(s)
      羽根正弥, 住田瑞季, 北島健, 佐藤ちひろ
    • Organizer
      糖鎖科学名古屋拠点「若手の力」フォーラム第10回
    • Place of Presentation
      静岡、日本
    • Related Report
      2012 Research-status Report
  • [Presentation] Molecular cloning and characterization of the insect CMP-sialic acid synthetases.

    • Author(s)
      呉迪, 藤田明子, 濵口香代, Anne Harduin-Lepers, Philippe Delannoy, Vladislav M. Panin, 佐藤ちひろ, 北島健
    • Organizer
      糖鎖科学名古屋拠点「若手の力」フォーラム第10回
    • Place of Presentation
      静岡、日本
    • Related Report
      2012 Research-status Report
  • [Presentation] ウニ配偶子におけるポリシアル酸構造と生合成酵素の多様性の解析

    • Author(s)
      萩原尚文、鳥山優、佐藤ちひろ、北島健
    • Organizer
      糖鎖科学名古屋拠点「若手の力」フォーラム第10回
    • Place of Presentation
      静岡、日本
    • Related Report
      2012 Research-status Report
  • [Presentation] ガングリオシド糖鎖ライブラリーを用いたSiglec-7の基質結合性の解析

    • Author(s)
      安田優*, 小崎仁美**、山川奈緒**、田中浩士, 高橋孝志, Paul Crocker, 北島健, 佐藤ちひろ
    • Organizer
      糖鎖科学名古屋拠点「若手の力」フォーラム第10回
    • Place of Presentation
      静岡、日本
    • Related Report
      2012 Research-status Report
  • [Presentation] Discovery, identification, and structure

    • Author(s)
      Estelle Garenaux (3人) Chihiro Sato, Ken Kitajima.
    • Organizer
      第30回日本糖質学会年会
    • Place of Presentation
      長岡リリックホール・ハイブ長岡・新潟
    • Related Report
      2011 Research-status Report
  • [Presentation] ブタ精子膜マイクロドメインに局在する糖タンパク質WGA-gpの生理機能.

    • Author(s)
      金沢尊、Waraporn Kasekarn、堀和紀、土山智之、佐藤ちひろ、安江博、北島健.
    • Organizer
      第30回日本糖質学会年会
    • Place of Presentation
      長岡リリックホール・ハイブ長岡・新潟
    • Related Report
      2011 Research-status Report
  • [Presentation] シアル酸ピルビン酸リアーゼによる細胞内シアル酸量の制御

    • Author(s)
      小林隆史、佐藤ちひろ、北島健
    • Organizer
      第30回日本糖質学会年年会
    • Place of Presentation
      長岡リリックホール・ハイブ長岡・新潟
    • Related Report
      2011 Research-status Report
  • [Presentation] 哺乳類シアリダーゼの細胞外活性の同定とその分泌機構の解析

    • Author(s)
      住田瑞季、矢部宇一郎、宮城妙子、Sadagopan Magesh、木曽真、北島健、佐藤ちひろ
    • Organizer
      第30回日本糖質学会年会
    • Place of Presentation
      長岡リリックホール・ハイブ長岡・新潟
    • Related Report
      2011 Research-status Report
  • [Presentation] メダカ卵表層胞糖タンパク質hyosophorinの糖鎖の発生における機能解析

    • Author(s)
      丸山恵実、佐藤ちひろ、足立朋子、橋本寿史、日比正彦、北島健
    • Organizer
      第30回日本糖質学会年会
    • Place of Presentation
      長岡リリックホール・ハイブ長岡・新潟
    • Related Report
      2011 Research-status Report
  • [Presentation] ウニ初期胚マイクロドメインに局在するユニークな糖鎖構造とその機能.

    • Author(s)
      萩原尚文、中村奈央子、佐藤ちひろ、鳥山優、北島健.
    • Organizer
      第30回日本糖質学会年会
    • Place of Presentation
      長岡リリックホール・ハイブ長岡・新潟
    • Related Report
      2011 Research-status Report
  • [Presentation] 表面プラズモン共鳴法を用いた神経作用因子とポリシアリル化NCAMとの相互作用解析.

    • Author(s)
      羽根正弥、小野明香、住田瑞季、北島健、佐藤ちひろ.
    • Organizer
      第30回日本糖質学会年会
    • Place of Presentation
      長岡リリックホール・ハイブ長岡・新潟
    • Related Report
      2011 Research-status Report
  • [Presentation] 分子モデリングによって推測されたSiglec-7の新規シアル酸認識領域の存在証明.

    • Author(s)
      小崎仁美、安田優、山川奈緒、田中浩士、高橋孝志、Paul Crocker, 北島健、佐藤ちひろ.
    • Organizer
      第30回日本糖質学会年会
    • Place of Presentation
      長岡リリックホール・ハイブ長岡・新潟
    • Related Report
      2011 Research-status Report
  • [Presentation] 魚類CMP-シアル酸合成酵素の性質比較.

    • Author(s)
      藤田明子、呉迪、安川裕子、佐藤ちひろ、北島健.
    • Organizer
      第30回日本糖質学会年会
    • Place of Presentation
      長岡リリックホール・ハイブ長岡・新潟
    • Related Report
      2011 Research-status Report
  • [Presentation] Structural and functional study of Lewis x-glyco

    • Author(s)
      Lan-Yi Chang, (4人), Chihiro Sato, Ken Kitajima
    • Organizer
      第30回日本糖質学会年会
    • Place of Presentation
      長岡リリックホール・ハイブ長岡・新潟
    • Related Report
      2011 Research-status Report
  • [Presentation] The potential decapacitation factor WGA16

    • Author(s)
      Garenaux, (3人), Sato, Kitajima.
    • Organizer
      第84回日本生化学会大会
    • Place of Presentation
      京都
    • Related Report
      2011 Research-status Report
  • [Presentation] シアル酸ピルビン酸リアーゼによる新規シアル酸合成経路の可能性

    • Author(s)
      小林隆史、佐藤ちひろ、北島健
    • Organizer
      第84回日本生化学会大会
    • Place of Presentation
      国立京都国際会館、京都
    • Related Report
      2011 Research-status Report
  • [Presentation] Structural and functional study of Lewis x

    • Author(s)
      Lan-Yi Chang, (4人), Chihiro Sato, Ken Kitajima
    • Organizer
      第84回日本生化学会大会
    • Place of Presentation
      国立京都国際会館、京都
    • Related Report
      2011 Research-status Report
  • [Presentation] エキソソームに局在する細胞外分泌シアリダーゼの同定および細胞刺激による分泌機構の解析

    • Author(s)
      住田瑞季、矢部宇一郎、宮城妙子、Sadagopan Magesh、木曽真、北島健、佐藤ちひろ
    • Organizer
      第84回日本生化学会大会
    • Place of Presentation
      国立京都国際会館、京都
    • Related Report
      2011 Research-status Report
  • [Presentation] ポリシアル酸およびポリシアリル化NCAMと神経作用因子との分子間相互作用の解析

    • Author(s)
      羽根正弥、小野明香、住田瑞季、北島健、佐藤ちひろ
    • Organizer
      第84回日本生化学会大会
    • Place of Presentation
      国立京都国際会館、京都
    • Related Report
      2011 Research-status Report
  • [Book] ポリシアル酸による神経機能の調節.実験医学31巻10号(増刊) 第三の生命鎖:糖鎖の機能と疾患(門松健治、遠藤玉夫、岡昌吾、北川裕之編集)2013

    • Author(s)
      佐藤ちひろ, 北島健
    • Publisher
      羊土社
    • Related Report
      2013 Final Research Report
  • [Book] The roles of carbohydrate binding in cell adhesion and inflammation. in Carbohydrate Recognition : Biological problems, methods, and applications (eds., Binghe Wang, Geer-Jan Boons)2011

    • Author(s)
      Kitajima K, and Sato C.
    • Publisher
      John Wiley and Sons
    • Related Report
      2013 Final Research Report
  • [Book] Carbohydrate Recognition2011

    • Author(s)
      Kitajima K, Sato C.
    • Total Pages
      30
    • Publisher
      John Wiley and Sons
    • Related Report
      2011 Research-status Report
  • [Book] Polysialic acids (Review). in Sialobiology : Structure, Biosynthesis, and Function. Sialic Acid Glycoconjugates in Health and Disease (Tiralongo J, Martinez-Duncker I, eds)

    • Author(s)
      Sato C.
    • Publisher
      Bentham Science
    • Related Report
      2013 Final Research Report
  • [Remarks] 名古屋大学生物機能開発利用研究センター公開実験講座で研究内容を一部講演

    • Related Report
      2013 Final Research Report
  • [Remarks] 名古屋大学生物機能開発利用研究センター動物細胞機能研究分野のHPで研究内容を一部紹介

    • Related Report
      2013 Final Research Report
  • [Remarks] Chihiro Sato and Ken Kitajima (2013) Carbohydrate analysis by gas-liquid chromatography, in GlycoScience Protocol Online Database (GlycoPOD), JCGGDB

    • URL

      http://jcggdb.jp/GlycoPOD/protocolShow.action?nodeId=t223

    • Related Report
      2013 Final Research Report
  • [Remarks] Carbohydrate analysis by gas-liquid chromatography

    • URL

      http://jcggdb.jp/GlycoPOD/protocolShow.action?nodeId=t223

    • Related Report
      2013 Annual Research Report

URL: 

Published: 2011-08-05   Modified: 2019-07-29  

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