Crystal Structure of Clostridium perfringens Enterotoxin.
| Project/Area Number |
23570134
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Structural biochemistry
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| Research Institution | Kyoto Institute of Technology |
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Principal Investigator |
KITADOKORO Kengo 京都工芸繊維大学, 工芸科学研究科, 准教授 (60283587)
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| Project Period (FY) |
2011 – 2013
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| Project Status |
Completed (Fiscal Year 2013)
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| Budget Amount *help |
¥5,460,000 (Direct Cost: ¥4,200,000、Indirect Cost: ¥1,260,000)
Fiscal Year 2013: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2012: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2011: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
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| Keywords | 構造生物学 / 食中毒 / 毒素タンパク質 / ウエルシュ菌 / 結晶化 / 感染症 |
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| Research Abstract |
Clostridium perfringens enterotoxin (CPE) is a cause of human food poisoning and considered to be a pore-forming toxin, which is supported by several lines of indirect evidence. The structure of CPE was determined by X-ray crystallography at 2.0 A resolution.
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Report
(4 results)
Research Products
(31 results)
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[Journal Article] Crystal Structure of Clostridiumperfringensenterotoxin displays features of β-pore-forming toxins2011
Author(s)
Kitadokoro, K., Nishimura, K., Kamitani, S., Fukui-Miyazaki, A., Toshima, H., Abe, H., Kamata, Y., Sugita-Konishi, Y., Yamamoto, S., Karatani, H., and Horiguchi, Y
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Journal Title
J Biol Chem
Volume: 286
Issue: 22
Pages: 19549-19555
DOI
Related Report
Peer Reviewed
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[Journal Article] Enzymatic actions of Pasteurella multocida toxin detected by monoclonal antibody recognizing the deamidated alpha subunit of the heterotrimeric GTPase Gq2011
Author(s)
Kamitani, S., Ao, S., Toshima, H., Tachibana, T., Hashimoto, M., Kitadokoro, K., Fukui-Miyazaki, A., Abe, H., and Horiguchi, Y.
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Journal Title
FEBS J
Volume: 278
Issue: 15
Pages: 2702-2712
DOI
Related Report
Peer Reviewed
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[Presentation] ウェルシュ菌の産生する食中毒病原因子CPEの構造および機能解析2011
Author(s)
西村昂亮, 神谷重樹, 福井理, 戸嶋ひろ野, 安倍裕順, 鎌田洋一, 小西良子, 山本茂貴, 柄谷肇, 堀口安彦, 北所健悟
Organizer
日本結晶学会・平成23年度年会および総会
Place of Presentation
北海道
Year and Date
2011-11-24
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