| Project/Area Number |
23570174
|
|---|
| Research Category |
Grant-in-Aid for Scientific Research (C)
|
| Allocation Type | Multi-year Fund |
|---|
| Section | 一般 |
|---|
| Research Field |
Functional biochemistry
|
|---|
| Research Institution | Tokyo University of Pharmacy and Life Science |
|---|
Principal Investigator |
INOUE Hiroki 東京薬科大学, 生命科学部, 講師 (10294448)
|
|---|
| Co-Investigator(Renkei-kenkyūsha) |
TAGAYA Mitsuo 東京薬科大学, 生命科学部, 教授 (30179569)
|
|---|
| Project Period (FY) |
2011 – 2013
|
| Project Status |
Completed (Fiscal Year 2013)
|
| Budget Amount *help |
¥5,460,000 (Direct Cost: ¥4,200,000、Indirect Cost: ¥1,260,000)
Fiscal Year 2013: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2012: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2011: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
|
|---|
| Keywords | 小胞輸送 / 上皮成長因子受容体 / トランスフェリン受容体 / SNARE / gamma-SNAP / DDHD2 / KIAA0725p / Rab11-FIP5 / g-SNAP / エンドサイトーシス / alpha-SNAP / invadopodia / 受容体輸送 |
|---|
| Research Abstract |
In this study, we revealed that DDHD2/KIAA0725p, phospholipase A1 against phosphatidic acid (PA), interacts with phosphatidylinositol 4-phosphate, thereby being recruited to ERGIC/Golgi. Moreover, this study showed that gamma-SNAP, which is a binding partner of PA-interacting Rab11 effector Rab11-FIP5, functions in disassembly of SNARE complex and regulates the trafficking of epidermal growth factor receptor and transferrin from early endosomes.
|
