| Budget Amount *help |
¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000)
Fiscal Year 2013: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2012: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2011: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
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| Research Abstract |
EOS1, whose function is important for oxidative stress tolerance in budding yeasts, was subjected to functional analyses. Based on phenotypic analyses using the partial deletion mutants of EOS1, I found the important region for enzymatic activity in Eos1 protein. As the results of gene expression analyses in EOS1 deletion variant, expression levels of many genes involved in elimination of reactive oxygen species (ROS) were increased. However, the expression levels of ROS degrading enzymes localized in intracellular organelles were reduced.
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