| Budget Amount *help |
¥5,590,000 (Direct Cost: ¥4,300,000、Indirect Cost: ¥1,290,000)
Fiscal Year 2013: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2012: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2011: ¥3,250,000 (Direct Cost: ¥2,500,000、Indirect Cost: ¥750,000)
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| Research Abstract |
We succeeded in synthesizing chemically poly-ethylene glycol cross-linked hydrogels comprised of actin. We have found that the storage modulus of this actin hydrogel autonomously oscillated for more than ten hours. The oscillatory properties of the actin hydrogels were based on both the treadmilling and gelation by chemical crosslinking of the filamentous actin structures. Thus oscillation can be caused by dynamic instability of actin filament. In this study, I developed simultaneous measurement system both mechanical strength and polymerization of actin, and build a model of oscillating actin gel based on dynamic instability. Additionally, exploring the specific motility of the cytoskeletal protein hydrogel when combined with kinesin linear motor protein.
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