Study of autonomous oscillation in PEG-crosslinked actin hydrogel
Project/Area Number |
23570181
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Research Category |
Grant-in-Aid for Scientific Research (C)
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Allocation Type | Multi-year Fund |
Section | 一般 |
Research Field |
Functional biochemistry
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Research Institution | Nippon Institute of Technology |
Principal Investigator |
SANO Ken-Ichi 日本工業大学, 工学部, 准教授 (80321769)
|
Project Period (FY) |
2011 – 2013
|
Project Status |
Completed (Fiscal Year 2013)
|
Budget Amount *help |
¥5,590,000 (Direct Cost: ¥4,300,000、Indirect Cost: ¥1,290,000)
Fiscal Year 2013: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2012: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2011: ¥3,250,000 (Direct Cost: ¥2,500,000、Indirect Cost: ¥750,000)
|
Keywords | アクチン / ダイナミックインスタビリティ / ナノバイオ / 微小管 / ハイドロゲル / 自励振動 / 生物物理 |
Research Abstract |
We succeeded in synthesizing chemically poly-ethylene glycol cross-linked hydrogels comprised of actin. We have found that the storage modulus of this actin hydrogel autonomously oscillated for more than ten hours. The oscillatory properties of the actin hydrogels were based on both the treadmilling and gelation by chemical crosslinking of the filamentous actin structures. Thus oscillation can be caused by dynamic instability of actin filament. In this study, I developed simultaneous measurement system both mechanical strength and polymerization of actin, and build a model of oscillating actin gel based on dynamic instability. Additionally, exploring the specific motility of the cytoskeletal protein hydrogel when combined with kinesin linear motor protein.
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Report
(4 results)
Research Products
(26 results)
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[Presentation] Slime mold in conflicting2013
Author(s)
Sano K., Ichimura M., Arai Y., Nakayama N., Hara M., Aono M.
Organizer
International Symposium on Advanced Soft Materials
Place of Presentation
札幌市
Year and Date
2013-10-18
Related Report
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[Presentation] 葛藤する真正粘菌とその解析2013
Author(s)
佐野健一, 新井裕太, 市村充, 中山典久, 原正彦, 青野真士
Organizer
第86回日本生化学会年会
Place of Presentation
横浜市
Year and Date
2013-09-11
Related Report
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[Presentation] Slime Mold in Conflicting
Author(s)
Ken-Ichi Sano, Makoto Ichimura, Yuta Arai, Norihisa Nakayama, Masahiko Hara, Masashi Aono
Organizer
International Symposium on Advanced Soft Materials
Place of Presentation
北海道大学(札幌)
Related Report
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