| Budget Amount *help |
¥5,590,000 (Direct Cost: ¥4,300,000、Indirect Cost: ¥1,290,000)
Fiscal Year 2013: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2012: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2011: ¥2,730,000 (Direct Cost: ¥2,100,000、Indirect Cost: ¥630,000)
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| Research Abstract |
Intrinsically disordered proteins (IDPs) have disordered structures in isolation but fold into specific structures upon binding to their partner molecules. Because 40% of eukaryotic proteins are considered to be IDPs, elucidation of the mechanism of molecular recognition by IDPs has been one of the crucial issues in biophysics. Here, we investigated the mechanisms of molecular recognition by IDPs using NMR and other techniques. We found that IDPs can recognize partner molecules very rapidly and that both the induced-fit and the conformational selection mechanisms are utilized in the recognition of partner molecules depending on IDPs.
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