Function of tubulin polyglutamylation in cilia/flagella motility mechanism
| Project/Area Number |
23570189
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Biophysics
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| Research Institution | Gakushuin University (2012-2013)
The University of Tokyo (2011) |
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Principal Investigator |
KAMIYA Ritsu 学習院大学, 理学部, 客員教授 (10124314)
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| Project Period (FY) |
2011 – 2013
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| Project Status |
Completed (Fiscal Year 2013)
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| Budget Amount *help |
¥5,460,000 (Direct Cost: ¥4,200,000、Indirect Cost: ¥1,260,000)
Fiscal Year 2013: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2012: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2011: ¥2,860,000 (Direct Cost: ¥2,200,000、Indirect Cost: ¥660,000)
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| Keywords | 運動・輸送 / 分子モーター / 翻訳後修飾 / 鞭毛・繊毛 / 微小管 / 細胞運動 / チューブリン / ダイニン / 鞭毛 / 生物物理 / 分子機械 / 細胞・組織 / タンパク質 |
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| Research Abstract |
To approach the function of tubulin polyglutamylation in cilia/flagella motility, we examined the motile properties of a Chlamydomonas tpg1, a mutant that lacks a tubulin polygultamylating enzyme (TTLL9). Motility analyses in double mutants between tpg1 and various kinds of dynein-deficient mutants revealed that long-chain tubulin polyglutamylation affects the function of only one particular species of dynein, inner arm dynein e, among more than 10 species of axonemal dyneins. Furthermore, studies using another mutant, tpg2, showed that a protein designated FAP234 functions in the transport and stabilization of TTLL9.
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Report
(4 results)
Research Products
(30 results)
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[Journal Article] TTC26/DYF13 is an intraflagellar transport protein required for transport of motility-related proteins into flagella.2014
Author(s)
Ishikawa H, Ide T, Yagi T, Jiang X, Hirono M, Sasaki H, Yanagisawa H, Wemmer KA, Stainier DY, Qin H, Kamiya R, Marshall WF.
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Journal Title
Elife.
Volume: 3
Pages: 1-24
DOI
Related Report
Peer Reviewed / Open Access
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[Journal Article] bop5 mutations reveal new roles for the IC138 phosphoprotein in the regulation of flagellar behavior2011
Author(s)
VanderWaal, K.E., Yamamoto, R., Wakabayashi, K., Fox, L., Kamiya, R., Dutcher, S.K., Bayly, P., Sale, W.S., and Porter, M.E.
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Journal Title
Molecular Biology of the Cell
Volume: 22
Issue: 16
Pages: 2862-74
DOI
Related Report
Peer Reviewed
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[Journal Article] A unified taxonomy for ciliary dyneins.2011
Author(s)
Hom EFY, Witman GB, Harris EH, Dutcher SK, Kamiya R., Mitchell DR, Pazour GJ, Porter ME, Sale WS, Wirchell M., Yagi T., King SM.
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Journal Title
Cytoskeleton
Volume: 68
Issue: 10
Pages: 555-65
DOI
Related Report
Peer Reviewed
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