Integration and regulatory mechanism for growth factor and cell adhesion signals
Project/Area Number |
23570227
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Research Category |
Grant-in-Aid for Scientific Research (C)
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Allocation Type | Multi-year Fund |
Section | 一般 |
Research Field |
Cell biology
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Research Institution | Osaka University |
Principal Investigator |
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Co-Investigator(Renkei-kenkyūsha) |
MEKADA Eisuke 大阪大学, 微生物病研究所, 教授 (20135742)
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Project Period (FY) |
2011-04-28 – 2015-03-31
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Project Status |
Completed (Fiscal Year 2014)
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Budget Amount *help |
¥5,330,000 (Direct Cost: ¥4,100,000、Indirect Cost: ¥1,230,000)
Fiscal Year 2013: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2012: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2011: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
|
Keywords | 増殖因子 / 細胞接着 / 細胞増殖 / 細胞骨格 |
Outline of Final Research Achievements |
To elucidate regulatory mechanism for integration of growth factor signal and cell adhesion signal, role of FAK, which is a common downstream signaling molecule of EGFR and integrin, and its regulatory mechanisms were examined. As a result, FAK was found out to be required for EGFR-dependent cell growth. Furthermore, a FAK mutant carrying phosphorylation-mimic mutation at FERM domain inhibited cell growth by interacting with microtubules through chaperones. Taken together these results, it was suggested that FAK could positively and negatively regulate cell growth depending on phosphorylation states of FERM domain.
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Report
(5 results)
Research Products
(8 results)
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[Journal Article] HB-EGF and PDGF mediate reciprocal interactions of carcinoma cells with cancer-associated fibroblasts to support progression of uterine cervical cancers2011
Author(s)
Murata T, Mizushima H, Chinen I, Moribe H, Yagi S, Hoffman RM, Kimura T, Yoshino K, Ueda Y, Enomoto T, Mekada E.
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Journal Title
Cancer Res.
Volume: 71 (21)
Pages: 6633-6642
Related Report
Peer Reviewed
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[Presentation] HB-EGF and PDGF Mediate Reciprocal Interactions of Carcinoma Cells with Cancer-Associated Fibroblasts to Support Progression of Uterine Cervical Cancers2012
Author(s)
Hiroto Mizushima, Takuya Murata, Ichino Chinen, Hiroki Moribe, Shigeo Yagi, Robert M Hoffman, Tadashi Kimura, Kiyoshi Yoshino, Yutaka Ueda, Takayuki Enomoto, Eisuke Mekada
Organizer
第45回日本発生学会、第64回日本細胞生物学会合同大会
Place of Presentation
神戸国際会議場
Related Report
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