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Integration and regulatory mechanism for growth factor and cell adhesion signals

Research Project

Project/Area Number 23570227
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field Cell biology
Research InstitutionOsaka University

Principal Investigator

MIZUSHIMA Hiroto  大阪大学, 微生物病研究所, 助教 (30379094)

Co-Investigator(Renkei-kenkyūsha) MEKADA Eisuke  大阪大学, 微生物病研究所, 教授 (20135742)
Project Period (FY) 2011-04-28 – 2015-03-31
Project Status Completed (Fiscal Year 2014)
Budget Amount *help
¥5,330,000 (Direct Cost: ¥4,100,000、Indirect Cost: ¥1,230,000)
Fiscal Year 2013: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2012: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2011: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
Keywords増殖因子 / 細胞接着 / 細胞増殖 / 細胞骨格
Outline of Final Research Achievements

To elucidate regulatory mechanism for integration of growth factor signal and cell adhesion signal, role of FAK, which is a common downstream signaling molecule of EGFR and integrin, and its regulatory mechanisms were examined. As a result, FAK was found out to be required for EGFR-dependent cell growth. Furthermore, a FAK mutant carrying phosphorylation-mimic mutation at FERM domain inhibited cell growth by interacting with microtubules through chaperones. Taken together these results, it was suggested that FAK could positively and negatively regulate cell growth depending on phosphorylation states of FERM domain.

Report

(5 results)
  • 2014 Annual Research Report   Final Research Report ( PDF )
  • 2013 Research-status Report
  • 2012 Research-status Report
  • 2011 Research-status Report
  • Research Products

    (8 results)

All 2015 2014 2013 2012 2011 Other

All Journal Article (2 results) (of which Peer Reviewed: 2 results,  Open Access: 1 results) Presentation (4 results) Remarks (2 results)

  • [Journal Article] Identification of diphtheria toxin R domain mutants with enhanced inhibitory activity against HB-EGF2015

    • Author(s)
      Suzuki K, Mizushima H, Abe H, Iwamoto R, Nakamura H, Mekada E
    • Journal Title

      J Biochem

      Volume: mvu079 Issue: 5 Pages: 331-343

    • DOI

      10.1093/jb/mvu079

    • NAID

      40020461422

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] HB-EGF and PDGF mediate reciprocal interactions of carcinoma cells with cancer-associated fibroblasts to support progression of uterine cervical cancers2011

    • Author(s)
      Murata T, Mizushima H, Chinen I, Moribe H, Yagi S, Hoffman RM, Kimura T, Yoshino K, Ueda Y, Enomoto T, Mekada E.
    • Journal Title

      Cancer Res.

      Volume: 71 (21) Pages: 6633-6642

    • Related Report
      2011 Research-status Report
    • Peer Reviewed
  • [Presentation] FAKリン酸化によるHB-EGF依存的細胞増殖制御2014

    • Author(s)
      水島寛人、船越敍希、目加田英輔
    • Organizer
      第66回日本細胞生物学会大会
    • Place of Presentation
      奈良県新公会堂
    • Year and Date
      2014-06-11 – 2014-06-13
    • Related Report
      2014 Annual Research Report
  • [Presentation] Sequestration of FAK on microtubule negatively regulates HB-EGF-dependent cell growth2013

    • Author(s)
      Hiroto Mizushima, Mitsuki Funakoshi, Eisuke Mekada
    • Organizer
      第65回日本細胞生物学会大会
    • Place of Presentation
      ウインクあいち(愛知県産業労働センター)
    • Related Report
      2013 Research-status Report
  • [Presentation] HB-EGF and PDGF Mediate Reciprocal Interactions of Carcinoma Cells with Cancer-Associated Fibroblasts to Support Progression of Uterine Cervical Cancers2012

    • Author(s)
      Hiroto Mizushima, Takuya Murata, Ichino Chinen, Hiroki Moribe, Shigeo Yagi, Robert M Hoffman, Tadashi Kimura, Kiyoshi Yoshino, Yutaka Ueda, Takayuki Enomoto, Eisuke Mekada
    • Organizer
      第45回日本発生学会、第64回日本細胞生物学会合同大会
    • Place of Presentation
      神戸国際会議場
    • Related Report
      2012 Research-status Report
  • [Presentation] Regulation of HB-EGF-dependent cell growth by phosphorylation of FERM domain of FAK

    • Author(s)
      Hiroto Mizushima, Mitsuki Funakoshi, Eisuke Mekada
    • Organizer
      第63回日本細胞生物学会大会
    • Place of Presentation
      北海道大学クラーク会館、学術交流会館(北海道)
    • Related Report
      2011 Research-status Report
  • [Remarks] 大阪大学微生物病研究所

    • URL

      http://www.biken.osaka-u.ac.jp/index.php

    • Related Report
      2012 Research-status Report
  • [Remarks] 大阪大学微生物病研究所細胞機能分野

    • URL

      http://cell-biology.biken.osaka-u.ac.jp/MekadaLabHP/Home.html

    • Related Report
      2012 Research-status Report

URL: 

Published: 2011-08-05   Modified: 2019-07-29  

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