The mechanism of Nup98-fusion mediated oncogenesis.
| Project/Area Number |
23570228
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Cell biology
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| Research Institution | Osaka University |
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Principal Investigator |
OKA Masahiro 大阪大学, 生命機能研究科, 助教 (40432504)
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| Project Period (FY) |
2011 – 2013
|
| Project Status |
Completed (Fiscal Year 2013)
|
| Budget Amount *help |
¥5,460,000 (Direct Cost: ¥4,200,000、Indirect Cost: ¥1,260,000)
Fiscal Year 2013: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Fiscal Year 2012: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2011: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
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| Keywords | ヌクレオポリン / 核膜孔 / Nup98 / 白血病 / Hox / ヒストン / がん化 / ヒストン修飾 / 細胞 |
|---|
| Research Abstract |
The function of oncogenic Nup98-fusion protein remains almost unknown. Our study demonstrated that Nup98-Hox localizes as small dots in the nucleus that frequently associated with specific histone modifications. Furthermore, the formation of these nuclear dots was dependent on the FG repeats of Nup98 and its associated factors.
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Report
(4 results)
Research Products
(24 results)
