Role of VCIP135 in Golgi reorganization
| Project/Area Number |
23570234
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Cell biology
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| Research Institution | Kyushu University |
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Principal Investigator |
TOTSUKAWA Go 九州大学, 医学(系)研究科(研究院), 助教 (90399684)
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| Project Period (FY) |
2011 – 2013
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| Project Status |
Completed (Fiscal Year 2013)
|
| Budget Amount *help |
¥5,330,000 (Direct Cost: ¥4,100,000、Indirect Cost: ¥1,230,000)
Fiscal Year 2013: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
Fiscal Year 2012: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
Fiscal Year 2011: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
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| Keywords | ゴルジ体 / VCIP135 / ユビキチン化 / オルガネラ / WAC |
|---|
| Research Abstract |
A novel VCIP135 binding protein is identified as WAC. WAC directly binds to VCIP135, and activates deubiquitinase activity of VCIP135 in vitro. WAC localizes to the Golgi, and functions as an essential factor for Golgi biogenesis. Interestingly, in Golgi reassembly, WAC functions only in p97/p47 membrane fusion pathway, but not in p97/p37 membrane fusion pathway. On the other hand, WAC has no function in ER biogenesis at all. It is suggested that ubiquitin signaling mediated by VCIP135/WAC plays a specific role in Golgi biogenesis, especially in mitosis.
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Report
(4 results)
Research Products
(5 results)
