| Budget Amount *help |
¥5,460,000 (Direct Cost: ¥4,200,000、Indirect Cost: ¥1,260,000)
Fiscal Year 2013: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2012: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2011: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
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| Research Abstract |
The aim of this study is to investigate molecular mechanism of the regulation of plasmalogen synthesis. Plasmalogen is a subtype of glycerophospholipids, in which a long chain fatty alcohol is linked at sn-1 position through a vinyl ether bond. Peroxisomal fatty acyl-CoA reductase 1 (Far1) is essential for supplying fatty alcohols required for ether bond formation in plasmalogen synthesis. Plasmalogen synthesis is regulated by modulating Far1 stability in a plasmalogen-dependent manner.
Here I found that Far1 is a peroxisomal tail-anchored protein. Far1, but not Far2, was preferentially degraded in response to the cellular level of plasmalogens. The region flanking the transmembrane domain of Far1 is required for plasmalogen-dependent degradation of Far1. The diversity of plasmalogens was formed through remodeling of fatty acids and Far1 stability is regulated in a manner dependent on certain type of plasmalogens.
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