Roles for neural crest derivatives in retaining motor neuron cell bodies in the fish embryonic spinal cord.

• Project/Area Number: 23570245
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Developmental biology
• Research Institution: Tohoku University
• Principal Investigator: SATO-MAEDA Mika 東北大学, 理学(系)研究科(研究院), 教育研究支援者 (40292205)
• Project Period (FY): 2011 – 2013
• Project Status: Completed (Fiscal Year 2013)
• Budget Amount: ¥5,330,000 (Direct Cost: ¥4,100,000、Indirect Cost: ¥1,230,000); Fiscal Year 2013: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000); Fiscal Year 2012: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000); Fiscal Year 2011: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
• Keywords: 神経冠細胞 / 運動神経 / グリア細胞 / Tag1 / 細胞間相互作用 / Schwann細胞 / TAG-1 / 細胞分化

Research Abstract

We showed Tag1-expressing neural crest cells (NCCs) play an important role to prevent motor neuron emigration from the embryonic spinal cord in Zebrafish. Tag1 deficiency causes disruption of NCC alignment along axon, cell death of NCC, and Schwann cell reduction. Such embryos show the dislocation of motor neuron cell body out of the spinal cord. The results show that the Tag1-mediated interaction between NCC and motor axon is required for the differentiation of functional Schwann cells, and that comparable function of NCC derivatives to retain the integrity of embryonic spinal cord is conserved among vertebrates.

Research Products

• [Presentation] 神経冠細胞は、ゼブラフィッシュ胚の運動神経・細胞体の位置を保持する機構に関与する (2013)
  • Author(s): 前田美香, 東海林亙
  • Organizer: 日本動物学会第84回大会
  • Place of Presentation: 岡山
  • Year and Date: 2013-09-28
• [Presentation] Tag1-mediated early interaction between neural crest cells and motor axons in zebrafish (2013)
  • Author(s): Mika Sato-Maeda, Wataru Shoji
  • Organizer: 6th Annual Meeting for the Japanese Society of Developmental Biologists
  • Place of Presentation: 松江
  • Year and Date: 2013-05-29
• [Presentation] Tag1-mediated early interaction between neural crest cells and motor axons in zebrafish. (2013)
  • Author(s): Mika Sato-Maeda、 Wataru Shoji
  • Organizer: 46th Annual Meeting for the Japanese Society of Developmental Biologists.
  • Place of Presentation: くにびきメッセ （島根県松江市）
• [Presentation] 神経冠細胞は、ゼブラフィッシュ胚の運動神経・細胞体の位置を保持する機構に関与する (2013)
  • Author(s): 前田美香、 東海林亙
  • Organizer: 日本動物学会第８４回大会
  • Place of Presentation: 岡山大学津島キャンパス （岡山市北区）
• [Presentation] Tag-1を介したゼブラフィッシュ一次運動神経軸索と神経冠細胞の相互作用 (2012)
  • Author(s): 前田美香, 東海林亙
  • Organizer: 日本動物学会第83回大会
  • Place of Presentation: 大阪
  • Year and Date: 2012-09-15
• [Presentation] Tag-1を介したゼブラフィッシュ一次運動神経軸索と神経冠細胞の相互作用 (2012)
  • Author(s): 前田美香 、東海林亙
  • Organizer: 日本動物学会 第８３回大会
  • Place of Presentation: 大阪大学豊中キャンパス（大阪）
• [Presentation] 運動神経軸索とシュワン前駆細胞の初期相互作用 (2011)
  • Author(s): 前田美香, 東海林亙
  • Organizer: 日本動物学会第82回大会
  • Place of Presentation: 旭川
  • Year and Date: 2011-09-22
• [Presentation] Early interaction of Schwann Precursors with motor axon (2011)
  • Author(s): 前田美香, 東海林亙
  • Organizer: 日本動物学会第82回大会
  • Place of Presentation: 三島
  • Year and Date: 2011-09-08
• [Presentation] Early interaction of Schwann Precursors with motor axon.
  • Author(s): 前田美香 (Sato-Maeda,Mika)
  • Organizer: 第１７回小型魚類研究会
  • Place of Presentation: 静岡県 三島市
• [Presentation] 運動神経軸索とシュワン前駆細胞の初期相互作用
  • Author(s): 前田美香
  • Organizer: 日本動物学会第82回大会
  • Place of Presentation: 旭川市
• [Remarks] Zebrafish group_our work
  • URL: http://www2.idac.tohoku.ac.jp/dep/cellbio/Our_work/Our_work.html