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Roles of cholesterol synthetic pathway during embryonic development

Research Project

Project/Area Number 23570246
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field Developmental biology
Research InstitutionTohoku University

Principal Investigator

SHOJI Wataru  東北大学, 学際科学フロンティア研究所, 准教授 (40250831)

Project Period (FY) 2011-04-28 – 2015-03-31
Project Status Completed (Fiscal Year 2014)
Budget Amount *help
¥5,460,000 (Direct Cost: ¥4,200,000、Indirect Cost: ¥1,260,000)
Fiscal Year 2013: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2012: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2011: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
Keywordszebrafish / blood vessel / cholosterol / ゼブラフィッシュ / 血管形成 / 神経発生
Outline of Final Research Achievements

Our previous study indicated Zebrafish mutant that has defect in cholesterol synthesis pathway exhibits blood vessel development. In this study, we report geranyl-geranyl products that derive from intermediate metabolite of this pathway, is essential for blood vessel development. Prenyl modification activates numbers of small G proteins, and we found rab family members are involved in the blood vessel formation. We are further investigating if same mechanism is conserved in mammalian blood vessels.

Report

(5 results)
  • 2014 Annual Research Report   Final Research Report ( PDF )
  • 2013 Research-status Report
  • 2012 Research-status Report
  • 2011 Research-status Report
  • Research Products

    (24 results)

All 2014 2013 2012 2011 Other

All Journal Article (4 results) (of which Peer Reviewed: 4 results,  Acknowledgement Compliant: 1 results) Presentation (16 results) Remarks (4 results)

  • [Journal Article] Hindbrain V2a neurons in the excitation of spinal locomotor circuits during zebrafish swimming2013

    • Author(s)
      Kimura, Y., Satou, C., Fujioka, S., Shoji, W., Umeda, K., Ishizuka, T., Yawo, H., and Higashijima, S.
    • Journal Title

      Current Biology

      Volume: 23 Issue: 10 Pages: 843-849

    • DOI

      10.1016/j.cub.2013.03.066

    • Related Report
      2013 Research-status Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Journal Article] Targeted expression of a chimeric channelrhodopsin in zebrafish under regulation of Gal4-UAS system.2013

    • Author(s)
      Umeda K, Shoji W Sakai S, Muto A, Kawakami K, Ishizuka T, and Yawo H
    • Journal Title

      Neuroscience Research

      Volume: 75 Issue: 1 Pages: 69-75

    • DOI

      10.1016/j.neures.2012.08.010

    • Related Report
      2012 Research-status Report
    • Peer Reviewed
  • [Journal Article] Application of Infrared Laser to the Zebrafish Vascular System: Gene Induction, Tracing, and Ablation of Single Endothelial Cells.2013

    • Author(s)
      Kimura E, Deguchi T, Kamei Y, Shoji W, Yuba S, Hitomi J.
    • Journal Title

      Arterioscler Thromb Vasc Biol.

      Volume: -

    • Related Report
      2012 Research-status Report
    • Peer Reviewed
  • [Journal Article] Dynamic changes in the gene expression of zebrafish Reelin receptors during embryogenesis and hatching period2012

    • Author(s)
      Hideaki Imai, Yoshihito Oomiya, Satoshi Kikkawa, Wataru Shoji, Masahiko Hibi, Toshio Terashima, Yu Katsuyama
    • Journal Title

      Development, Growth & Differentiation

      Volume: Vol.54 Issue: 2 Pages: 253-263

    • DOI

      10.1111/j.1440-169x.2012.01327.x

    • Related Report
      2011 Research-status Report
    • Peer Reviewed
  • [Presentation] Optogenetic analysis of escape behavior in zebrafish larvae2014

    • Author(s)
      Umeda, K., Shoji, W.
    • Organizer
      第20回小型魚類研究会
    • Place of Presentation
      東京都
    • Year and Date
      2014-09-20 – 2014-09-21
    • Related Report
      2014 Annual Research Report
  • [Presentation] ゼブラフィッシュ幼生逃避行動における光遺伝学的機能解析2014

    • Author(s)
      梅田桂子、東海林亙
    • Organizer
      第49回日本発生生物学会大会
    • Place of Presentation
      名古屋市
    • Year and Date
      2014-05-27 – 2014-05-30
    • Related Report
      2014 Annual Research Report
  • [Presentation] Optogenetic analysis of escape behavior in zebrafish larvae2014

    • Author(s)
      梅田桂子、東海林亙
    • Organizer
      第7回神経発生討論会
    • Place of Presentation
      吹田市
    • Related Report
      2013 Research-status Report
  • [Presentation] Tag-1-mediated early interaction between neural crest cells and motor axons in zebrafish2013

    • Author(s)
      Sato-Maeda, M. and Shoji, W.
    • Organizer
      第47回日本発生生物学会大会
    • Place of Presentation
      松江市
    • Related Report
      2013 Research-status Report
  • [Presentation] Gene induction, tracing, and ablation of the targeted single endothelial cells using IR-LEGO system2013

    • Author(s)
      Kimura. E., Deguchi, T., Kamei, Y., Shoji, W., Yuba, S., Hitomi, J.
    • Organizer
      第19回小型魚類研究会
    • Place of Presentation
      仙台市
    • Related Report
      2013 Research-status Report
  • [Presentation] Motion prediction, tracking and stabilization of free-swimiming zebrafish2013

    • Author(s)
      Ihara, T., Yanglei, G., Matsui, S., Fei, X., Shoji, W., Hashimoto, K.
    • Organizer
      第19回小型魚類研究会
    • Place of Presentation
      仙台市
    • Related Report
      2013 Research-status Report
  • [Presentation] Microscope systems for tracking zebrafish and light stimulation2013

    • Author(s)
      Matsui, S., Shoji, W., Hashimoto, K.
    • Organizer
      第19回小型魚類研究会
    • Place of Presentation
      仙台市
    • Related Report
      2013 Research-status Report
  • [Presentation] 神経冠細胞はゼブラフィッシュ胚の運動神経・細胞体の位置の保持に関与する2013

    • Author(s)
      前田(佐藤)美香、東海林亙
    • Organizer
      第84回日本動物学会年会
    • Place of Presentation
      岡山市
    • Related Report
      2013 Research-status Report
  • [Presentation] 第83回日本動物学会年会2012

    • Author(s)
      前田美香、東海林亙
    • Organizer
      TAG-1を介したゼブラフィッシュ一次運動神経軸索と神経冠 細胞の相互作用
    • Place of Presentation
      大阪
    • Related Report
      2012 Research-status Report
  • [Presentation] Optogenetic analysis of fin movement2012

    • Author(s)
      Wataru Shoji
    • Organizer
      第18回小型魚類研究会
    • Place of Presentation
      京都
    • Related Report
      2012 Research-status Report
  • [Presentation] Spatio-temporally regulated gene induction in the targeted single endothelial cells using an infrared laser2012

    • Author(s)
      Kimura. E., Deguchi, T., Kamei, Y., Shoji, W., Yuba, S., Hitomi, J.
    • Organizer
      第20回日本血管生物医学会学術集会 / 第10回 Korea-Japan Joint Symposium on Vascular Biology
    • Place of Presentation
      徳島
    • Related Report
      2012 Research-status Report
  • [Presentation] IR-LEGO顕微鏡を用いた血管内皮細胞における1細胞レベルでの遺伝子発現系の樹立2012

    • Author(s)
      木村英二、出口友則、亀井保博、東海林亙、弓場俊輔、人見次郎
    • Organizer
      第35回日本分子生物学会年会
    • Place of Presentation
      福岡
    • Related Report
      2012 Research-status Report
  • [Presentation] Optogenetic stimulation of transgenic zebrafish expressing an optimized channelrhodopsin variant2011

    • Author(s)
      Umeda, K., Shoji, W., Sakai, S., Ishizuka, T., Yawo, H.
    • Organizer
      8th IBRO World Congress of Neuroscience
    • Place of Presentation
      イタリア フローレンス
    • Related Report
      2011 Research-status Report
  • [Presentation] Early Interaction of Schwann precursors with motor axon2011

    • Author(s)
      Sato-Maeda, M., and Shoji, W.
    • Organizer
      第17回小型魚類研究会
    • Place of Presentation
      三島
    • Related Report
      2011 Research-status Report
  • [Presentation] Transgenic zebrafish expressing optimized channelrhodopsin in Rohon-Beard neurons: escape behavior by light,2011

    • Author(s)
      梅田桂子、東海林亙、酒井誠一郎、石塚徹、八尾寛
    • Organizer
      第34回日本神経科学大会
    • Place of Presentation
      横浜
    • Related Report
      2011 Research-status Report
  • [Presentation] 運動神経軸索とシュワン細胞の初期相互作用2011

    • Author(s)
      前田(佐藤)美香、東海林亙
    • Organizer
      第82回日本動物学会年会
    • Place of Presentation
      旭川
    • Related Report
      2011 Research-status Report
  • [Remarks] 東北大学学際科学フロンティア研究所・先端学際基幹研究部ホームページ

    • URL

      http://www.fris.tohoku.ac.jp/fris/organization/advanced/shoji.html

    • Related Report
      2014 Annual Research Report
  • [Remarks] 東北大学加齢医学研究所ホームページ

    • URL

      http://www.idac.tohoku.ac.jp/ja/activities/research/project_programs/syoji/index.html

    • Related Report
      2012 Research-status Report
  • [Remarks] 東海林研究室独自ホームページ

    • URL

      http://www2.idac.tohoku.ac.jp/dep/cellbio/Welcome.html

    • Related Report
      2012 Research-status Report
  • [Remarks]

    • URL

      http://www2.idac.tohoku.ac.jp/dep/cellbio/Welcome.html

    • Related Report
      2011 Research-status Report

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Published: 2011-08-05   Modified: 2019-07-29  

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