| Budget Amount *help |
¥5,460,000 (Direct Cost: ¥4,200,000、Indirect Cost: ¥1,260,000)
Fiscal Year 2013: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2012: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2011: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
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| Outline of Final Research Achievements |
Our previous study indicated Zebrafish mutant that has defect in cholesterol synthesis pathway exhibits blood vessel development. In this study, we report geranyl-geranyl products that derive from intermediate metabolite of this pathway, is essential for blood vessel development. Prenyl modification activates numbers of small G proteins, and we found rab family members are involved in the blood vessel formation. We are further investigating if same mechanism is conserved in mammalian blood vessels.
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