Roles of cholesterol synthetic pathway during embryonic development
Project/Area Number |
23570246
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Research Category |
Grant-in-Aid for Scientific Research (C)
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Allocation Type | Multi-year Fund |
Section | 一般 |
Research Field |
Developmental biology
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Research Institution | Tohoku University |
Principal Investigator |
SHOJI Wataru 東北大学, 学際科学フロンティア研究所, 准教授 (40250831)
|
Project Period (FY) |
2011-04-28 – 2015-03-31
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Project Status |
Completed (Fiscal Year 2014)
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Budget Amount *help |
¥5,460,000 (Direct Cost: ¥4,200,000、Indirect Cost: ¥1,260,000)
Fiscal Year 2013: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2012: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2011: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
|
Keywords | zebrafish / blood vessel / cholosterol / ゼブラフィッシュ / 血管形成 / 神経発生 |
Outline of Final Research Achievements |
Our previous study indicated Zebrafish mutant that has defect in cholesterol synthesis pathway exhibits blood vessel development. In this study, we report geranyl-geranyl products that derive from intermediate metabolite of this pathway, is essential for blood vessel development. Prenyl modification activates numbers of small G proteins, and we found rab family members are involved in the blood vessel formation. We are further investigating if same mechanism is conserved in mammalian blood vessels.
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Report
(5 results)
Research Products
(24 results)
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[Journal Article] Hindbrain V2a neurons in the excitation of spinal locomotor circuits during zebrafish swimming2013
Author(s)
Kimura, Y., Satou, C., Fujioka, S., Shoji, W., Umeda, K., Ishizuka, T., Yawo, H., and Higashijima, S.
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Journal Title
Current Biology
Volume: 23
Issue: 10
Pages: 843-849
DOI
Related Report
Peer Reviewed / Acknowledgement Compliant
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[Presentation] Gene induction, tracing, and ablation of the targeted single endothelial cells using IR-LEGO system2013
Author(s)
Kimura. E., Deguchi, T., Kamei, Y., Shoji, W., Yuba, S., Hitomi, J.
Organizer
第19回小型魚類研究会
Place of Presentation
仙台市
Related Report
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[Presentation] Motion prediction, tracking and stabilization of free-swimiming zebrafish2013
Author(s)
Ihara, T., Yanglei, G., Matsui, S., Fei, X., Shoji, W., Hashimoto, K.
Organizer
第19回小型魚類研究会
Place of Presentation
仙台市
Related Report
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[Presentation] Spatio-temporally regulated gene induction in the targeted single endothelial cells using an infrared laser2012
Author(s)
Kimura. E., Deguchi, T., Kamei, Y., Shoji, W., Yuba, S., Hitomi, J.
Organizer
第20回日本血管生物医学会学術集会 / 第10回 Korea-Japan Joint Symposium on Vascular Biology
Place of Presentation
徳島
Related Report
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