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Study on anteroposterior and dorsoventral axes in echinoderm

Research Project

Project/Area Number 23570248
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field Developmental biology
Research InstitutionThe University of Tokyo

Principal Investigator

AKASAKA Koji  東京大学, 理学(系)研究科(研究院), 教授 (60150968)

Project Period (FY) 2011 – 2013
Project Status Completed (Fiscal Year 2013)
Budget Amount *help
¥5,460,000 (Direct Cost: ¥4,200,000、Indirect Cost: ¥1,260,000)
Fiscal Year 2013: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2012: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2011: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
Keywords棘皮動物 / 体軸 / Hox / 神経系 / 国際情報交換 / 五放射相称 / 前後軸 / 背腹軸 / Hoxクラスター / chordin / BMP2/4 / Pax6
Research Abstract

Pentameral symmetry is a characteristic of echinoderms, which do not have a clear anterior-posterior axis and lack head structures. Hox cluster genes are broadly conserved across deuterostomes and protostomes, and are demonstrated a linear cluster structure in the genome. Expression patterns on the anterior-posterior axis are also identical in the ordering of the genes in the genome and in developmental stages, demonstrating a relation to formation patterns along the anterior posterior axis. The spatial expression patterns of crinoid Oxycomanthus japonicus and sea cucumber Apostichopus japonicus were examined. Co-linearity expression of the Hox gene cluster along the axis is not observed in Oxycomanthus japonicus; however the co-linearity expression along the gut in Apostichopus japonicus; which has obvious external anterior posterior axis, is observed. The results imply that the function of Hox cluster genes is different in different groups of echinoderm.

Report

(4 results)
  • 2013 Annual Research Report   Final Research Report ( PDF )
  • 2012 Research-status Report
  • 2011 Research-status Report
  • Research Products

    (36 results)

All 2014 2013 2012 2011 Other

All Journal Article (11 results) (of which Peer Reviewed: 11 results) Presentation (23 results) Remarks (2 results)

  • [Journal Article] Ca2+ influx-linked protein kinase C activity regulates the b-catenin localization, micromere induction signaling and the oral-aboral axis formation in early sea urchin embryos.2014

    • Author(s)
      Yazaki I, Tsurugaya T, Santella L, Chun JT, Amore G, Kusunoki S, Asada A, Togo T, Akasaka K.
    • Journal Title

      Zygote

      Volume: Apr9 Issue: 3 Pages: 1-12

    • DOI

      10.1017/s0967199414000033

    • Related Report
      2013 Annual Research Report 2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] Current Status of Echinoderm Genome Analysis - What Do We Know?2012

    • Author(s)
      Kondo, M. and Akasaka, K.
    • Journal Title

      Current Genomics

      Volume: 13 Issue: 2 Pages: 134-143

    • DOI

      10.2174/138920212799860643

    • Related Report
      2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] A lineage specific enhancer drives Otx2 expression in teleost organizer tissues2012

    • Author(s)
      Daisuke Kurokawa, Tomomi Ohmura, Koji Akasaka, Shinichi Aizawa
    • Journal Title

      Mechanisms of Development

      Volume: 128 Issue: 11-12 Pages: 653-661

    • DOI

      10.1016/j.mod.2011.11.001

    • Related Report
      2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] Sea urchin coelomocyte arylsulfatase:a modulator of the echinoderm clotting pathway2012

    • Author(s)
      Winslow L D A, Radke D W, Utecht T, Kaneko T, Akasaka K
    • Journal Title

      Integrative Zoology

      Volume: 7

    • Related Report
      2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] Nucleosome exclusion from the interspecies conserved central AT-rich region of the Ars insulator2012

    • Author(s)
      Takagi H.
    • Journal Title

      J.Biochem.

      Volume: 151 Issue: 1 Pages: 75-87

    • DOI

      10.1093/jb/mvr118

    • Related Report
      2013 Final Research Report 2012 Research-status Report 2011 Research-status Report
    • Peer Reviewed
  • [Journal Article] Sea urchin coelomocyte arylsulfatase: a modulator of the echinoderm clotting pathway2012

    • Author(s)
      Lisanne D’ Andrea Winslow, David W. Radke, Tim Utecht, Takuya Kaneko, Koji Akasaka
    • Journal Title

      Integrative Zoology

      Volume: 7 Pages: 61-73

    • Related Report
      2012 Research-status Report
    • Peer Reviewed
  • [Journal Article] A lineage specific enhancer drives Otx2 expression in teleost organizer tissues2012

    • Author(s)
      Daisuke Kurokawa, Tomomi Ohmura, Koji Akasaka, Shinichi Aizawa
    • Journal Title

      Mechanisms of Development

      Volume: 128 Pages: 653-661

    • Related Report
      2012 Research-status Report
    • Peer Reviewed
  • [Journal Article] Current Status of Echinoderm Genome Analysis - What do we Know?2012

    • Author(s)
      Kondo M and Akasaka K
    • Journal Title

      Current Genomics

      Volume: 13 Pages: 134-143

    • Related Report
      2012 Research-status Report
    • Peer Reviewed
  • [Journal Article] Improvement of a phiC31 integrase-based gene delivery system that confers high and continuous transgene expression2011

    • Author(s)
      Watanabe S, Nakamura S, Sakurai T, Akasaka K, Sato M
    • Journal Title

      N Biotechnol

      Volume: 28 Issue: 4 Pages: 312-319

    • DOI

      10.1016/j.nbt.2010.11.001

    • Related Report
      2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] Gene expression analysis of Six3 Pax6 and Otx in the early development of the stalked crinoid Metacrinus rotundus2011

    • Author(s)
      Omori A, Kurokawa D, Akasaka K, Amemiya S
    • Journal Title

      Gene Exp Patterns

      Volume: 11 Issue: 1-2 Pages: 48-56

    • DOI

      10.1016/j.gep.2010.09.002

    • Related Report
      2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] Gene expression analysis of Six3, Pax6 and Otx in the early development of the stalked crinoid Metacrinus rotundus2011

    • Author(s)
      Omori A, Kurokawa D, Akasaka K, Amemiya S.
    • Journal Title

      Gene Exp. Patterns

      Volume: 11 Pages: 48-56

    • Related Report
      2011 Research-status Report
    • Peer Reviewed
  • [Presentation] DNAマーカーを用いたイボアシウミシダ科ウミシダ類2種の分類再検討2013

    • Author(s)
      大森紹仁、幸塚久典、赤坂甲治、小郷一三
    • Organizer
      日本動物学会第84回大会
    • Place of Presentation
      岡山大学
    • Related Report
      2013 Final Research Report
  • [Presentation] Study on the formation of the anteroposterior body axis of the sea cucumber Apostichopus japonicus2013

    • Author(s)
      Kikuchi M, Akasaka K
    • Organizer
      CDV symposium 2013
    • Place of Presentation
      RIKEN CDB Kobe
    • Related Report
      2013 Final Research Report
  • [Presentation] DNAマーカーを用いたイボアシウミシダ科ウミシダ類2種の分類再検討2013

    • Author(s)
      大森紹仁、幸塚久典、赤坂甲治、小郷一三
    • Organizer
      日本動物学会 第84回大会
    • Place of Presentation
      岡山大学(岡山県)
    • Related Report
      2013 Annual Research Report
  • [Presentation] Study on the formation of the anteroposterior body axis of the sea cucumber Apostichopus japonicus2013

    • Author(s)
      Mani Kikuchi, Koji Akasaka
    • Organizer
      CDV symposium 2013(The Making of a Vertebrate)
    • Place of Presentation
      理化学研究所発生・再生科学総合研究センター 兵庫県
    • Related Report
      2012 Research-status Report
  • [Presentation] マナマコApostichopus japonicusの前後軸形成機構の研究2012

    • Author(s)
      菊池摩仁,赤坂甲治
    • Organizer
      第9回棘皮動物研究集会
    • Year and Date
      2012-12-08
    • Related Report
      2013 Final Research Report
  • [Presentation] Gene expression during regeneration of an echinoderm, Oxycomanthus japonicus2012

    • Author(s)
      Kondo M, Ueda S, Sawafuji R, Tsurugaya T, Omori A, Akasaka K
    • Organizer
      第35回日本分子生物学会年会
    • Place of Presentation
      福岡
    • Related Report
      2013 Final Research Report
  • [Presentation] Study on the formation of the anteroposterior body axis of the sea cucumber Apostichopus japonicus2012

    • Author(s)
      Kikuchi M, Akasaka K
    • Organizer
      Developmental Biology of the Sea Urchin XXI
    • Place of Presentation
      Woods Hole, MA 02543, USA
    • Related Report
      2013 Final Research Report 2012 Research-status Report
  • [Presentation] ニッポンウミシダ再生過程における遺伝子発現の解析2012

    • Author(s)
      上田修作,大森紹仁,鶴ヶ谷柊子,赤坂甲治,近藤真理子
    • Organizer
      日本動物学会第83回大会
    • Place of Presentation
      大阪
    • Related Report
      2013 Final Research Report
  • [Presentation] Immunohistochemical and molecular biological analysis on the adult nervous systems of the feather star Oxycomanthus japonicus2012

    • Author(s)
      Omori A, Kurokawa D, Akasaka K
    • Organizer
      4th International Echinoderm Conference
    • Place of Presentation
      Brussels, Belgium
    • Related Report
      2013 Final Research Report
  • [Presentation] Immunohistochemical and molecular biological analysis on the adult nervous systems of the feather star Oxycomanthus japonicus.2012

    • Author(s)
      Akihito Omori, Daisuke Kurokawa, Koji Akasaka.
    • Organizer
      14th International Echinoderm Conference
    • Place of Presentation
      Brussels, Belgium
    • Related Report
      2012 Research-status Report
  • [Presentation] Gene expression during regeneration of a crinoid, Oxycomanthus japonicus2012

    • Author(s)
      M. Kondo, S Ueda, R Sawafuji, T Tsurugaya, A Omori, K Akasaka
    • Organizer
      Developmental Biology of the Sea Urchin XXI
    • Place of Presentation
      Woods Hole, MA 02543, USA
    • Related Report
      2012 Research-status Report
  • [Presentation] Gene expression during regeneration of an echinoderm, Oxycomanthus japonicus2012

    • Author(s)
      Mariko Kondo, Shusaku Ueda, Rikai Sawafuji, Toko Tsurugaya, Akihito Omori, Koji Akasaka
    • Organizer
      第35回日本分子生物学会年会
    • Place of Presentation
      福岡国際会議場・マリンメッセ福岡 福岡
    • Related Report
      2012 Research-status Report
  • [Presentation] ニッポンウミシダ再生過程における遺伝子発現の解析2012

    • Author(s)
      上田修作,大森紹仁,鶴ヶ谷柊子,赤坂甲治,近藤真理子
    • Organizer
      日本動物学会第83回大会
    • Place of Presentation
      大阪大学 大阪
    • Related Report
      2012 Research-status Report
  • [Presentation] マナマコApostichopus japonicusの前後軸形成機構の研究2012

    • Author(s)
      菊池摩仁・赤坂甲治
    • Organizer
      第9回棘皮動物研究集会
    • Place of Presentation
      東北大学 仙台
    • Related Report
      2012 Research-status Report
  • [Presentation] Advantage of sea urchin embryos for the analysis of GRN2011

    • Author(s)
      Akasaka K
    • Organizer
      Commemorative Symposium for the 27th International Prize for Biology
    • Place of Presentation
      Kyoto Garden Palace Koto Japan
    • Year and Date
      2011-12-01
    • Related Report
      2013 Final Research Report
  • [Presentation] ニッポンウミシダ成体神経系におけるRNA結合因子の発現解析2011

    • Author(s)
      大森紹仁, 黒川大輔, 赤坂甲治
    • Organizer
      日本動物学会第82回大会
    • Place of Presentation
      旭川
    • Year and Date
      2011-09-21
    • Related Report
      2013 Final Research Report 2011 Research-status Report
  • [Presentation] 棘皮動物ニッポンウミシダの再生過程におけるレチノイン酸遺伝子の発現2011

    • Author(s)
      上田修作, 大森紹仁, 澤藤りかい, 池田つぼみ, 井上祐介, 赤坂甲治, 近藤真理子
    • Organizer
      日本動物学会第82回大会
    • Place of Presentation
      旭川
    • Year and Date
      2011-09-21
    • Related Report
      2013 Final Research Report 2011 Research-status Report
  • [Presentation] バフンウニ成体におけるHox遺伝子の発現解析2011

    • Author(s)
      袖山文彰, 鶴ヶ谷柊子, 黒川大輔, 赤坂甲治
    • Organizer
      日本動物学会第82回大会
    • Place of Presentation
      旭川
    • Year and Date
      2011-09-21
    • Related Report
      2013 Final Research Report
  • [Presentation] マナマコの体軸形成機構の研究2011

    • Author(s)
      菊池摩仁, 黒川大輔, 近藤真理子, 吉国通庸, 赤坂甲治
    • Organizer
      日本動物学会第82回大会
    • Place of Presentation
      旭川
    • Year and Date
      2011-09-21
    • Related Report
      2013 Final Research Report 2011 Research-status Report
  • [Presentation] Analysis of Hox genes of a crinoid Oxycomanthus japonicus2011

    • Author(s)
      Kondo M, Tsurugaya T, Sumiyoshi N, Omori A, Ikuta T, Ota T, Ikeo K, Saiga H, Akasaka K
    • Organizer
      The Developmental Biology of the Sea Urchin XIX
    • Place of Presentation
      Marine Biological Laboratory Woods Hole MA 02543 USA
    • Year and Date
      2011-05-27
    • Related Report
      2013 Final Research Report
  • [Presentation] Analysis of Hox genes of a crinoid, Oxycomanthus japonicus2011

    • Author(s)
      Mariko Kondo, Toko Tsurugaya, Noriko Sumiyoshi, Akihito Omori, Tetsuro Ikuta, Tatsuya Ota, Kazuho Ikeo, Hidetoshi Saiga, Koji Akasaka
    • Organizer
      The Developmental Biology of the Sea Urchin XIX
    • Place of Presentation
      Marine Biological Laboratory Woods Hole, MA 02543, USA
    • Related Report
      2011 Research-status Report
  • [Presentation] Advantage of sea urchin embryos for the analysis of GRN2011

    • Author(s)
      Akasaka K.
    • Organizer
      Commemorative Symposium for the 27th International Prize for Biology
    • Place of Presentation
      Kyoto Garden Palace, Koto, Japan
    • Related Report
      2011 Research-status Report
  • [Presentation] バフンウニ成体におけるHox 遺伝子の発現解析2011

    • Author(s)
      袖山文彰,鶴ヶ谷柊子,黒川大輔,赤坂甲治
    • Organizer
      日本動物学会第82回大会
    • Place of Presentation
      旭川
    • Related Report
      2011 Research-status Report
  • [Remarks]

    • URL

      http://www.mmbs.s.u-tokyo.ac.jp/

    • Related Report
      2013 Final Research Report
  • [Remarks] 各教員の研究内容

    • URL

      http://www.mmbs.s.u-tokyo.ac.jp/jp/research/individuals.html

    • Related Report
      2012 Research-status Report

URL: 

Published: 2011-08-05   Modified: 2019-07-29  

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